Cumulative live birth rate in women aged ≤37 years after in vitro fertilization with or without preimplantation genetic testing for aneuploidy: a Society for Assisted Reproductive Technology Clinic Outcome Reporting System retrospective analysis

Preimplantation genetic testing for aneuploidy in patients under 37: easy come, easy go

“…There were also differences between cycle characteristics between groups, with those using PGT-A having a higher average total follicle-stimulating hormone dose and higher use of intracytoplasmic sperm injection. Overall, Mejia et al’s ( 1 ) results are consistent with the largest trials and meta-analyses that have been performed on this topic to date ( 2 , 3 , 4 ). The cumulative live birth rate is no different in women 35–37 years of age who transfer tested vs. untested embryos (66.6% vs. 62.5%; aOR: 0.92, 95% CI: 0.83–1.01).…”

“…This month’s article by Mejia et al. ( 1 ) adds to the growing and ever-convincing body of evidence, both prospective and retrospective that indicates that preimplantation genetic testing for aneuploidy (PGT-A) in a young cohort (<37 years) does not improve reproductive outcomes.…”

“…Mejia et al. ( 1 ) reviewed 31,900 patients from the Society for Assisted Reproductive Technology Clinic Outcome Reporting System database aged 21–37 years who were undergoing their first autologous oocyte retrieval from 2014–2016. Of these, 2,538 were classified as undergoing PGT-A.…”

“…Data from Mejia et al. ( 1 ) suggest that PGT-A in women <35 years of age is associated with a lower cumulative live birth rate compared with the transfer of untested embryos and offers no benefit to those aged 35–37 years. It is ok that PGT-A does not provide uniform benefits across all age groups—we already know which age groups stand to benefit the most from aneuploidy screening.…”

Does PGT-A affect cumulative live birth rate?

“…Retrospective studies analyzing SART outcomes from retrieval cycles performed between 2014 and 2015 demonstrated that the CLBR per transfer when employing PGT-A only becomes beneficial once looking at women of advanced reproductive age [11 ▪ ,14 ▪ ]. SART defines cumulative live birth as up to one live birth per retrieval cycle and transfer cycles linked to that retrieval [4].…”