2013
DOI: 10.1111/bcpt.12143
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Cumulative Mitoxantrone‐Induced Haematological and Hepatic Adverse Effects in a Subchronic In vivo Study

Abstract: Mitoxantrone (MTX) is an antineoplastic agent that can induce hepato-and haematotoxicity. This work aimed to investigate the occurrence of cumulative early and late MTX-induced hepatic and haematological disturbances in an vivo model. A control group and two groups treated with three cycles of 2.5 mg/kg MTX at days 0, 10 and 20 were formed. One of the treated groups suffered euthanasia on day 22 (MTX22) to evaluate early MTX toxic effects, while the other suffered euthanasia on day 48 (MTX48), to allow the eva… Show more

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Cited by 13 publications
(8 citation statements)
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“…The results were consistent with previous rodent researches. Hepatotoxic signs, reduced hepatic levels and increased oxidized glutathione, and decreased ATP hepatic levels were reported in rat liver with mitoxantrone treatment, confirming the mitoxantrone-induced hepatotoxicity in rat [ 48 ].…”
Section: Discussionmentioning
confidence: 74%
“…The results were consistent with previous rodent researches. Hepatotoxic signs, reduced hepatic levels and increased oxidized glutathione, and decreased ATP hepatic levels were reported in rat liver with mitoxantrone treatment, confirming the mitoxantrone-induced hepatotoxicity in rat [ 48 ].…”
Section: Discussionmentioning
confidence: 74%
“…Adenosine triphosphate measurement ATP measurement in liver and kidney homogenates was performed by the luciferin/luciferase bioluminescence assay, as described before (Rossato et al, 2014). Briefly, 150 μl of tissue homogenates were neutralized with 150 μl of 0.76 M KHCO 3 and centrifuged at 16 000 g, for 1 min, at 4°C.…”
Section: Oxidative Stress Parametersmentioning
confidence: 99%
“…The increased expression levels of oxidation and detoxification genes together with altered histopathology, confirmed the mitoxantrone‐induced liver damage in zebrafish. A parallel observation of increased oxidized GSH and decreased hepatic ATP levels in rat liver with mitoxantrone treatment advocates the similarity of results in the zebrafish model in comparison to mammals (Rossato et al, 2014).…”
Section: Liver Injury Models In Zebrafishmentioning
confidence: 84%