Cumulative pregnancy rate after ICSI-IVF in patients with colorectal endometriosis: results of a multicentre study

Ballester, Marcos; d’Argent, Emmanuelle Mathieu; Morcel, Karine; Belaïsch-Allart, J.; Nisolle, Michelle; Daraı̈, Émile

doi:10.1093/humrep/des012

Cited by 91 publications

(110 citation statements)

References 37 publications

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“…Previous studies [37,44] have reported a lower PR in women with endometriosis associated with adenomyosis. However, these authors did not distinguish between external and internal adenomyosis or between diffuse and focal adenomyosis.…”

Section: Limiting Factors When Evaluating Fertility In Women With Colmentioning

confidence: 69%

“…Moreover, in accordance with a previous study [35], no difference in PR was noted between women with colorectal endometriosis and those with tubal or male infertility. Subsequently, in a multicenter study including the women from Mathieu d'Argent et al's series, Ballester et al [37] showed that the cumulative PRs after one and two IVF-ICSI cycles were 29.3 and 52.9%, respectively. In this specific setting, we are currently waiting for the results of an ongoing trial comparing first-intention MAR and colorectal surgery in women with patent fallopian tubes and without associated male infertility to build a therapeutic strategy.…”

Section: Fertility After Mar In Women With In Situ Colorectal Endometmentioning

confidence: 99%

“…Three studies reported the PR after MAR including the two previously mentioned series with resection of DIE and leaving in situ colorectal endometriosis [32,33] and one including patients with no surgery [37] …”

Section: Fertility After Mar In Women With In Situ Colorectal Endometmentioning

confidence: 99%

“…However, these authors did not distinguish between external and internal adenomyosis or between diffuse and focal adenomyosis. Ballester et al [37] demonstrated the negative impact of adenomyosis on PR with no additional pregnancy being obtained after the first IVF-ICSI cycle. Finally, a recent meta-analysis including five series of rectovaginal and colorectal endometriosis reported a PR of only 11.9% in women with concomitant adenomyosis while the PR was 43.0% in those without [15].…”

Section: Limiting Factors When Evaluating Fertility In Women With Colmentioning

confidence: 99%

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Colorectal endometriosis and fertility

Daraı̈

Cohen

Ballester

2017

European Journal of Obstetrics & Gynecology and Reproductiv

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Objective: The goal of this review was to assess the impact of colorectal endometriosis on spontaneous fertility and the potential benefit of Medically Assisted Reproduction (MAR) (in vitro fertilization and intrauterine insemination) and surgery on fertility outcomes.Study design: MEDLINE search for articles on fertility in women with DIE published between 1990 and December 2015 using the following terms: "deep endometriosis", "deep infiltrating endometriosis", "bowel endometriosis", "colorectal endometriosis", "fertility", "infertility", "IVF-ICSI", "Assisted Reproductive Techniques (ART)", and "MAR".Results: Spontaneous pregnancy rate (PR) in patients undergoing resection of DIE but leaving in situ colorectal endometriosis was 26.5% (95% CI = 14-39). PR after MAR was 27.4% (95% CI = 19-35) and the overall PR was 37.9% (95% CI = 29-37). After colorectal surgery, among the 855 patients with and without proved infertility, the spontaneous PR was 31.4% (95% CI = 28-34) without difference between the groups. PR after MAR was 19.8% (95% CI = 17-22). PR after MAR in patients with and without proved infertility was 21.4% (95% CI = 18-25) and 15.5% (95% CI = 11-20), respectively. The overall PR after colorectal surgery was 51.1% (95% CI = 48-54). Conclusion:Our review supports a potential benefit of surgery on fertility outcomes for women with colorectal endometriosis. Further studies are required to determine whether surgical management should be first-intention or restricted to failure of MAR.

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Section: Limiting Factors When Evaluating Fertility In Women With Colmentioning

confidence: 69%

Section: Fertility After Mar In Women With In Situ Colorectal Endometmentioning

confidence: 99%

Section: Fertility After Mar In Women With In Situ Colorectal Endometmentioning

confidence: 99%

Section: Limiting Factors When Evaluating Fertility In Women With Colmentioning

confidence: 99%

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Colorectal endometriosis and fertility

Daraı̈

Cohen

Ballester

2017

European Journal of Obstetrics & Gynecology and Reproductiv

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“…Dies verdeutlicht, dass die Ansprüche an die Patientinnenselektion für eine Operation und die Qualität der Operation entscheidende Erfolgsfaktoren sind. Natür-lich beeinflussen weitere Faktoren wie Alter, Serum-AMH-Spiegel und das Vorhandensein anderer Begleitfaktoren die Prognose entscheidend [2]. Somit wird jeder einzelne Fall eine individuelle Betrachtung und Beratung erfordern.…”

Section: Heterogenität Des Endometriosekollektivsunclassified

Kinderwunsch und Schwangerschaft bei Endometriose

Shebl

Ebner

Oppelt

2016

Gynäkologische Endokrinologie

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Pregnancy rate following endometriomas management by ablation using plasma energy, cystectomy and drainage: A three‐arm comparative study

Puşcaşiu

Mircea

Hennetier

et al. 2022

Intl J Gynecology & Obste

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Objective To compare differences in the postoperative pregnancy rate in women seeking to conceive and presenting with endometriomas larger than 3 cm in diameter, which were managed by ablation using plasma energy, cystectomy, or simple drainage. Methods A retrospective three‐arm comparative study based on prospective collection of data evaluating 363 patients, undergoing endometrioma cystectomy, ablation using plasma energy, or simple drainage. Results In this series, 204 (56.2%) patients underwent endometrioma ablation using plasma energy, 121 (33.3%) received cystectomy, and 38 (10.5%) had a simple drainage. Postoperative follow up was 50 ± 26 months. Overall postoperative pregnancy rate was 60.3%. The probability of being pregnant after cystectomy, ablation, and drainage was respectively 27%, 32%, and 16% at 12 months, with a statistically significant difference between pregnancy rates among the three arms (P = 0.015). Simple drainage was associated with a probability of conception over 50% after 2 years, mainly based on postoperative assisted reproductive technology. Conclusions We reveal good postoperative pregnancy rate after ablation using plasma energy or cystectomy for endometriomas. Surgical management should be carefully considered in women with endometriomas and pregnancy intention, because the postoperative pregnancy rate may be compared with that observed after first‐line assisted reproductive technology management.

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Cumulative pregnancy rate after ICSI-IVF in patients with colorectal endometriosis: results of a multicentre study

Abstract: Our data confirm that ICSI-IVF offers a high CPR per patient. However, determinant factors of CPR should be taken into account when informing couples of their options.

Cited by 91 publications

References 37 publications

Colorectal endometriosis and fertility

Colorectal endometriosis and fertility

Kinderwunsch und Schwangerschaft bei Endometriose

Pregnancy rate following endometriomas management by ablation using plasma energy, cystectomy and drainage: A three‐arm comparative study

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