Cumulative risk assessment of the exposure to pyrethroids through fruits consumption in China – Based on a 3-year investigation

Li, Zhixia; Nie, Jun; Lu, Zeqi; Xie, Hanzhong; Lu, Kang; Chen, Qiusheng; Liu, An; Zhao, Xubo; Xu, Guofeng; Yan, Zhiying

doi:10.1016/j.fct.2016.08.012

Cited by 54 publications

(16 citation statements)

References 24 publications

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“…The major route of exposure for humans is through ingestion of food items treated with PYRs (151). Even though PYRs have relative short half-lives ranging from 3-to 96-days in soil (152), they are found in environmental samples (153,154), human samples (155) and food (156), probably as a result of excessive and repeated use. Given PYRs structural resemblance to T3 and T4, PYRs insecticides are suspected to act as TH disruptors (150).…”

Section: Pyrethroidsmentioning

confidence: 99%

Pesticides With Potential Thyroid Hormone-Disrupting Effects: A Review of Recent Data

et al. 2019

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Plant Protection Products, more commonly referred to as pesticides and biocides, are used to control a wide range of yield-reducing pests including insects, fungi, nematodes, and weeds. Concern has been raised that some pesticides may act as endocrine disrupting chemicals (EDCs) with the potential to interfere with the hormone systems of non-target invertebrates and vertebrates, including humans. EDCs act at low doses and particularly vulnerable periods of exposure include pre-and perinatal development. Of critical concern is the number of pesticides with the potential to interfere with the developing nervous system and brain, notably with thyroid hormone signaling. Across vertebrates, thyroid hormone orchestrates metamorphosis, brain development, and metabolism. Pesticide action on thyroid homeostasis can involve interference with TH production and its control, displacement from distributor proteins and liver metabolism. Here we focused on thyroid endpoints for each of the different classes of pesticides reviewing epidemiological and experimental studies carried out both in in vivo and in vitro. We conclude first, that many pesticides were placed on the market with insufficient testing, other than acute or chronic toxicity, and second, that thyroid-specific endpoints for neurodevelopmental effects and mixture assessment are largely absent from regulatory directives.

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Section: Pyrethroidsmentioning

confidence: 99%

Pesticides With Potential Thyroid Hormone-Disrupting Effects: A Review of Recent Data

et al. 2019

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“…From the theory of zero threshold to the concept of acceptable risk under certain probability conditions, it then evolved into the maximum allowable daily intake in food. The Codex Committee on Pesticide Residues (CCPR) believes that the maximum daily intake Amount (ADI) is not the only criterion for toxicological risk assessment (Li et al, 2016).…”

Section: Risk Assessmentmentioning

confidence: 99%

Residues, degradation behavior of cyproconazole in Sichuan pepper and its dietary risk assessment

Xu¹,

Ren²,

Xu³

et al. 2021

Preprint

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In this study, an efficient method was developed and validated to determine cyproconazole in Sichuan pepper samples using the QuEChERS procedure and ultrahigh-performance liquid chromatography-tandem mass spectrometry. The average recoveries of the method were 96.2%-104.5% with the relative standard deviation (RSDs) below 7.6%, the limit of detection (LOD), and the limit of quantitation (LOQ) was 0.001 mg/kg and 0.02 mg/kg. The field trial results showed that cyproconazole in two Sichuan pepper matrices was rapidly dissipated with half-lives less than 8.8 days, which could be regarded as an easy degradation pesticide. The terminal residues of cyproconazole in Sichuan pepper samples were lower than the maximum residue limit (MRL) set by China (0.2 mg/kg registered on wheat). The calculated hazard quotient and acute hazard index lower than 100% illustrated that the use of cyproconazole, even at 1.5 times the highest recommended dose, does not pose any hazards to consumers.

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“…Pyrethroids are highly efficient and broad-spectrum insecticides developed rapidly since the 1970s, occupying 38% of the world insecticide market currently. As an unpleasant consequence, the excessive use of pyrethroids in agriculture and homes has made non-target organisms and even human suffered from uncertain health risks and survival threats (Li et al, 2016). B. subtilis is proved to degrade pyrethroids owing to its highly catalytic carboxylesterases (Bhatt et al, 2020), and previously a bacterial strain B. subtilis BSF01 was isolated with excellent pyrethroid-degrading ability (Xiao et al, 2015).…”

Section: Introductionmentioning

confidence: 99%

Synergistic Degradation of Pyrethroids by the Quorum Sensing-Regulated Carboxylesterase of Bacillus subtilis BSF01

Xiao

et al. 2020

Front. Bioeng. Biotechnol.

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The well-studied quorum sensing (QS) mechanism has established a complex knowledge system of how microorganisms behave collectively in natural ecosystems, which contributes to bridging the gap between the ecological functions of microbial communities and the molecular mechanisms of cell-to-cell communication. In particular, the ability of agrochemical degradation has been one most attractive potential of functional bacteria, but the interaction and mutual effects of intracellular degradation and intraspecific behavior remained unclear. In this study, we establish a connection between QS regulation and biodegradation by harnessing the previously isolated Bacillus subtilis BSF01 as a template which degrades various pyrethroids. First, we characterize the genetic and transcriptional basis of comA-involved QS system in B. subtilis BSF01 since the ComQXPA circuit coordinates group behaviors in B. subtilis isolates. Second, the genetic and transcriptional details of pyrethroid-degrading carboxylesterase CesB are defined, and its catalytic capacity is evaluated under different conditions. More importantly, we adopt DNA pull-down and yeast one-hybrid techniques to reveal that the enzymatic degradation of pyrethroids is initiated through QS signal regulator ComA binding to carboxylesterase gene cesB, highlighting the synergistic effect of QS regulation and pyrethroid degradation in B. subtilis BSF01. Taken together, the elucidated mechanism provides novel details on the intercellular response of functional bacteria against xenobiotic exposure, which opens up possibilities to facilitate the in-situ contaminant bioremediation via combining the QS-mediated strategies.

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Cumulative risk assessment of the exposure to pyrethroids through fruits consumption in China – Based on a 3-year investigation

Cited by 54 publications

References 24 publications

Pesticides With Potential Thyroid Hormone-Disrupting Effects: A Review of Recent Data

Pesticides With Potential Thyroid Hormone-Disrupting Effects: A Review of Recent Data

Residues, degradation behavior of cyproconazole in Sichuan pepper and its dietary risk assessment

Synergistic Degradation of Pyrethroids by the Quorum Sensing-Regulated Carboxylesterase of Bacillus subtilis BSF01

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