Cupping Reversal in Pediatric Glaucoma—Evaluation of the Retinal Nerve Fiber Layer and Visual Field

Illuminated Microcatheter Circumferential Trabeculotomy Versus Combined Trabeculotomy-Trabeculectomy for Primary Congenital Glaucoma: A Randomized Controlled Trial

“…[31][32][33] However, clinical cupping reversal in pediatric glaucoma may not necessarily corroborate with retinal nerve fiber layer thickness on optical coherence tomography, which may show stable or even reduced thickness following IOP reduction post surgery. 34 Significant improvement (P < .001) in corneal clarity in both groups also suggests no difference in success outcomes between the 2 procedures. Sufficient corneal clearing post combined trabeculotomy and trabeculectomy has also been reported by other authors.…”

Assessment of Retinal Nerve Fiber Layer Thickness in Healthy, Full-Term Neonates

“…Peripapillary RNFL measurements were originally used to assess optic nerve axonal integrity in glaucomatous versus normal adults’ eyes 1,2 and later adapted to monitor other optic neuropathies. 3 Similarly, measuring RNFL thicknesses in children improves diagnosis and monitoring of optic neuropathies unique to the pediatric population 4–11 and can identify differences in CNS tissue between children with a history of preterm versus full-term birth. 12–15 While normative data of RNFL thicknesses exists for school-age children, 11,16–24 this data is lacking during the neonatal period (PubMed Mesh search terms, nerve fiber layer AND infant), while the immature optic nerves are still growing and undergoing myelination.…”

Morphological Diagnostics in Paediatric Glaucoma-Analysis of the Disc Damage Likelihood Scale by KOWA Non Mydriatic Fundus Camera and its Correlation to HRT and OCT

“…Paediatric glaucoma showed characteristics that differ compared to the primary open angle glaucoma (POAG) in adults. For example, cup reversal, topographic improvement of the optic disc after glaucoma therapy, and different genetic mutations can be observed in paediatric but not POAG glaucoma [21][22][23]. The most difficult diagnostic process is to detect beginning glaucomatous changes in children before irreversible damage occurs.…”