If a certain solubilization of lipoproteic material takes place during treatments of knitted wool fabrics with sodium sulphite in an isopropanol/water medium, and if these treatments prevent wool shrinkage at some particular conditions of solvent concentration and temperature, then a relationship exists between the dissolved lipoproteic material and the shrinkproofing effect. The lipids of the fiber play an important role in obtaining this effect.Numerous reports have appeared in the literature about morphological modifications at the cuticular level of wool fibers that have been shrinkproofed [ 13,16, 18]. The fiber residue dissolved in the treatment bath has, however, been only minimally studied [7]. Different workers have reported on the internal lipids localized in the cell membrane complex (CMC) of keratin fibers [1,3,5,14,23], and others propose the presence of a lipidic layer at the outer surface of the fiber on the epicuticle, which is not eliminated during organic solvent extraction [ 15].In this paper, we report on a relationship between the dissolution of the lipoproteic material and the shrinkproofing effect obtained when knitted wool fab-rics are treated with a nucleophilic agent in an aqueous organic polar solvent bath. Since the s6rinkproofing effect in these treatments depends on the organic polar solvent concentration and the temperature [8], we studied the effect of these two parameters on the dissolution of the lipoproteic material. Experimental MATERIALS Fabrics knitted to a cover factor of 12.6 from R72tex/2 botany wool yarns supplied by IWS (Bkley) were used. Before being treated, fabrics were cleaned by