Cuproptosis/OXPHOS tendency prediction of prognosis and immune microenvironment of esophageal squamous cell carcinoma: Bioinformatics analysis and experimental validation

Li, Liang; Cheng, Haiyan; Gong, Li; Huang, Yongcheng; Yang, Jie; Yan, Qihang; Dai, Shuqin; Wang, Junye

doi:10.1016/j.gene.2024.148156

Gene

2024

DOI: 10.1016/j.gene.2024.148156

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Cuproptosis/OXPHOS tendency prediction of prognosis and immune microenvironment of esophageal squamous cell carcinoma: Bioinformatics analysis and experimental validation

Liang Li,

Haiyan Cheng,

Li Gong

et al.

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Cited by 4 publications

References 43 publications

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Targeting cuproptosis for cancer therapy: Focus on the anti-tumor immune system

Zhang,

Han

2024

Cancer Pathogenesis and Therapy

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Targeting cuproptosis for cancer therapy: Focus on the anti-tumor immune system

Zhang,

Han

2024

Cancer Pathogenesis and Therapy

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The crosstalk between copper-induced oxidative stress and cuproptosis: a novel potential anticancer paradigm

Vo,

Peng,

Nguyen

et al. 2024

Cell Commun Signal

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Copper is a crucial trace element that plays a role in various pathophysiological processes in the human body. Copper also acts as a transition metal involved in redox reactions, contributing to the generation of reactive oxygen species (ROS). Under prolonged and increased ROS levels, oxidative stress occurs, which has been implicated in different types of regulated cell death. The recent discovery of cuproptosis, a copper-dependent regulated cell death pathway that is distinct from other known regulated cell death forms, has raised interest to researchers in the field of cancer therapy. Herein, the present work aims to outline the current understanding of cuproptosis, with an emphasis on its anticancer activities through the interplay with copper-induced oxidative stress, thereby providing new ideas for therapeutic approaches targeting modes of cell death in the future.

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Is 26S proteasome non-ATPase regulatory subunit 6 a potential molecular target for intrahepatic cholangiocarcinoma?

Zhuang,

Tong,

Sun

2024

World J Hepatol

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In this editorial we comment on the article by Tang et al published in the recent issue of World Journal of Hepatology . Drug therapy of intrahepatic cholangiocarcinoma (iCCA) poses an enormous challenge since only a small proportion of patients demonstrate beneficial responses to therapeutic agents. Thus, there has been a sustained search for novel molecular targets for iCCA. The study by Tang et al evaluated the role of 26S proteasome non-ATPase regulatory subunit 6 (PSMD6), a 19S regulatory subunit of the proteasome, in human iCCA cells and specimens. The authors employed clustered regularly interspaced short palindromic repeat (CRISPR) knockout screening technology integrated with the computational CERES algorithm, and analyzed the human protein atlas (THPA) database and tissue microarrays. The results show that PSMD6 is a gene essential for the proliferation of 17 iCCA cell lines, and PSMD6 protein was overexpressed in iCCA tissues without a significant correlation with the clinicopathological parameters. The authors conclude that PSMD6 may play a promoting role in iCCA. The major limitations and defects of this study are the lack of detailed information of CRISPR knockout screening, in vivo experiments, and a discussion of plausible mechanistic cues, which, therefore, dampen the significance of the results. Further studies are required to verify PSMD6 as a molecular target for developing novel therapeutics for iCCA. In addition, the editorial article summarizes the latest advances in molecular targeted drugs and recently emerging immunotherapy in the clinical management of iCCA, development of proteasome inhibitors for cancer therapy, and advantages of CRISPR screening technology, computational methods, and THPA database as experimental tools for fighting cancer. We hope that these comments may provide some clues for those engaged in the field of basic and clinical research into iCCA.

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Cuproptosis/OXPHOS tendency prediction of prognosis and immune microenvironment of esophageal squamous cell carcinoma: Bioinformatics analysis and experimental validation

Cited by 4 publications

References 43 publications

Targeting cuproptosis for cancer therapy: Focus on the anti-tumor immune system

Targeting cuproptosis for cancer therapy: Focus on the anti-tumor immune system

The crosstalk between copper-induced oxidative stress and cuproptosis: a novel potential anticancer paradigm

Is 26S proteasome non-ATPase regulatory subunit 6 a potential molecular target for intrahepatic cholangiocarcinoma?

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