2023
DOI: 10.3390/ijms24021464
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Cuproptosis-Related LncRNA-Based Prediction of the Prognosis and Immunotherapy Response in Papillary Renal Cell Carcinoma

Abstract: Cuproptosis, a new cell death pattern, is promising as an intervention target to treat tumors. Abnormal long non-coding RNA (lncRNA) expression is closely associated with the occurrence and development of papillary renal cell carcinoma (pRCC). However, cuproptosis-related lncRNAs (CRLs) remain largely unknown as prognostic markers for pRCC. We aimed to forecast the prognosis of pRCC patients by constructing models according to CRLs and to examine the correlation between the signatures and the inflammatory micr… Show more

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Cited by 13 publications
(6 citation statements)
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“…Compared to existing signatures including several lncRNAs (more than 6) [25,26], our 3-lncRNA model contains the fewer genes and should be easy to apply in the clinic. Different functional lncRNA models, specifically ferroptosis/cuproptosis-associated lncRNA signatures and tumor-infiltrating lymphocyte-related lncRNA models, have been reported to predict ccRCC prognosis [27][28][29]. However, these lncRNAs in models are closely related to immunotherapy and drug response but not to ccRCC prognosis.…”
Section: Discussionmentioning
confidence: 99%
“…Compared to existing signatures including several lncRNAs (more than 6) [25,26], our 3-lncRNA model contains the fewer genes and should be easy to apply in the clinic. Different functional lncRNA models, specifically ferroptosis/cuproptosis-associated lncRNA signatures and tumor-infiltrating lymphocyte-related lncRNA models, have been reported to predict ccRCC prognosis [27][28][29]. However, these lncRNAs in models are closely related to immunotherapy and drug response but not to ccRCC prognosis.…”
Section: Discussionmentioning
confidence: 99%
“…Relevant risk curves and heatmaps were then plotted using the “survival,” “glmnet,” “survminer,” and “timeROC” R packages[ 23 , 24 ]. The following equation was then used to obtain the risk score[ 25 ]: Risk score = Σi = lnCoef (i) × Expr (i). The risk expression (Expr(i)) and risk coefficient (Coef(i)) functions represent the corresponding risk coefficient and risk expression.…”
Section: Methodsmentioning
confidence: 99%
“…Multivariate cox regression analysis was applied to build a two-lncRNA predictive model. The calculated formula used for disulfidptosis-related prognostic risk score was based on the published documents 22 , 38 . The model of risk score was calculated as follows: risk score = ∑i = LnCoef(i) × EXP(i).…”
Section: Methodsmentioning
confidence: 99%