2024
DOI: 10.1186/s12964-024-01625-7
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Cuproptosis: unveiling a new frontier in cancer biology and therapeutics

Ying Feng,
Zhibo Yang,
Jianpeng Wang
et al.

Abstract: Copper plays vital roles in numerous cellular processes and its imbalance can lead to oxidative stress and dysfunction. Recent research has unveiled a unique form of copper-induced cell death, termed cuproptosis, which differs from known cell death mechanisms. This process involves the interaction of copper with lipoylated tricarboxylic acid cycle enzymes, causing protein aggregation and cell death. Recently, a growing number of studies have explored the link between cuproptosis and cancer development. This re… Show more

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Cited by 12 publications
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