Cuprous oxide nanoparticles trigger ER stress-induced apoptosis by regulating copper trafficking and overcoming resistance to sunitinib therapy in renal cancer

Yang, Qiwei; Wang, Ye; Yang, Qing; Gao, Yi; Duan, Xidong; Fu, Qingcheng; Chu, Chuanmin; Pan, Xiuwu; Cui, Xingang; Sun, Yinghao

doi:10.1016/j.biomaterials.2017.09.008

Cited by 84 publications

(61 citation statements)

References 33 publications

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“…Zinc oxide (ZnO) NPs are among the most commonly used nanomaterials, with a wide range of applications including biomedical imaging, drug and gene delivery, biosensing, and antibacterial and antifungal applications [18]. Copper oxide (CuO) has a high potential in the development of biosensors [19][20][21], antifouling coatings [22,23], and biocidal [24][25][26] and antitumor agents [27][28][29]. Boehmite (AlOOH) can be used as an adjuvant for vaccines [30,31].…”

Section: Introductionmentioning

confidence: 99%

Effects of Metal Oxide Nanoparticles on Toll-Like Receptor mRNAs in Human Monocytes

et al. 2020

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For the widespread application of nanotechnology in biomedicine, it is necessary to obtain information about their safety. A critical problem is presented by the host immune responses to nanomaterials. It is assumed that the innate immune system plays a crucial role in the interaction of nanomaterials with the host organism. However, there are only fragmented data on the activation of innate immune system factors, such as toll-like receptors (TLRs), by some nanoparticles (NPs). In this study, we investigated TLRs’ activation by clinically relevant and promising NPs, such as Fe3O4, TiO2, ZnO, CuO, Ag2O, and AlOOH. Cytotoxicity and effects on innate immunity factors were studied in THP-1(Tohoku Hospital Pediatrics-1) cell culture. NPs caused an increase of TLR-4 and -6 expression, which was comparable with the LPS-induced level. This suggests that the studied NPs can stimulate the innate immune system response inside the host. The data obtained should be taken into account in future research and to create safe-by-design biomedical nanomaterials.

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Section: Introductionmentioning

confidence: 99%

Effects of Metal Oxide Nanoparticles on Toll-Like Receptor mRNAs in Human Monocytes

et al. 2020

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“…Briefly, cells were harvested and washed three times with PBS, and stained with 10 mM DCFH-DA in serum-free cell culture medium at 37∘C for 30 min, with inversion every 5 min. The cells were then washed three times with serum-free medium, and the fluorescent product DCF was measured using a spectrofluorimeter with excitation at 484 nm and emission at 530 nm [20]. …”

Section: Methodsmentioning

confidence: 99%

Tanshinone IIA Attenuates Contrast-Induced Nephropathy via Nrf2 Activation in Rats

Liang

Zhao

Cheng

et al. 2018

Cell Physiol Biochem

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Background/Aims: Tanshinone IIA is a chemical compound extracted from Salvia miltiorrhiza Bunge, a perennial plant also known as red sage used in traditional Chinese medicine. Tanshinone IIA has been shown to protect against various organ injuries. In this study, we hypothesized that Tanshinone IIA could play an anti-oxidative role in contrast-induced nephropathy (CIN) through enhancing Nrf2/ARE activation. Methods: To test whether Tanshinone IIA can attenuate CIN, oxidative stress, and apoptosis, we utilized two models: an in vivo Sprague-Dawley rat model of ioversol-induced CIN and an in vitro cell model of oxidative stress in which HK2 cells, a human renal tubular cell line, are treated with hydrogen peroxide (H₂O₂). Rats were randomly assigned to 4 groups (n = 6 per group): control group, ioversol group (ioversol-induced CIN), vehicle group (ioversol-induced CIN rats pretreated with vehicle), and Tanshinone IIA group (ioversol-induced CIN rats pretreated with 25mg/kg Tanshinone IIA). Renal functions, renal injuries and apoptosis were evaluated by using serum creatinine, histological scoring, and TUNEL staning respectively. Malondialdehyde, 8-hydroxy-2’ –deoxyguanosine, and intracellular reactive oxygen species were used for oxidative stress assessment. Levels of Nrf2 and heme oxygenase-1 (HO-1) were measured in vivo and in vitro. Results: Tanshinone IIA attenuated renal tubular necrosis, apoptosis and oxidative stress in rats and oxidative stress in HK2 cells. Furthermore, Tanshinone IIA activated Nrf2, and up-regulated HO-1 expression in vivo and in vitro, resulting in a reduction in oxidative stress. Conclusion: Tanshinone IIA may protect against CIN through enhancing Nrf2/ARE activation.

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“…Although chemotherapy is one of the main modes of cancer treatment, its effectiveness is limited by drug resistance. For example, sunitinib is currently the standard first-line treatment for advanced RCC, and patient inevitably become resistant to sunitinib treatment ( Yang et al, 2017 ). In addition, the clinical outcomes in patients with RCC remain poor.…”

Section: Nanotechnology In Renal Cancermentioning

confidence: 99%

Potential Applications of Nanotechnology in Urological Cancer

Chen

Zheng

et al. 2018

Front. Pharmacol.

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Nowadays, the potential scope of nanotechnology in uro-oncology (cancers of the prostate, bladder, and kidney) is broad, ranging from drug delivery, prevention, and diagnosis to treatment. Novel drug delivery methods using magnetic nanoparticles, gold nanoparticles, and polymeric nanoparticles have been investigated in prostate cancer. Additionally, renal cancer treatment may be profoundly influenced by applications of nanotechnology principles. Various nanoparticle-based strategies for kidney cancer therapy have been proposed. Partly due to the dilution of drug concentrations by urine production, causing inadequate drug delivery to tumor cells in the treatment of bladder cancer, various multifunctional bladder-targeted nanoparticles have been developed to enhance therapeutic efficiency. In each of these cancer research fields, nanotechnology has shown several advantages over widely used traditional methods. Different types of nanoparticles improve the solubility of poorly soluble drugs, and multifunctional nanoparticles have good specificity toward prostate, renal, and bladder cancer. Moreover, nanotechnology can also combine with other novel technologies to further enhance effectivity. As our understanding of nanotechnologies grows, additional opportunities to improve the diagnosis and treatment of urological cancer are excepted to arise. In this review, we focus on nanotechnologies with potential applications in urological cancer therapy and highlight clinical areas that would benefit from nanoparticle therapy.

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Cuprous oxide nanoparticles trigger ER stress-induced apoptosis by regulating copper trafficking and overcoming resistance to sunitinib therapy in renal cancer

Cited by 84 publications

References 33 publications

Effects of Metal Oxide Nanoparticles on Toll-Like Receptor mRNAs in Human Monocytes

Effects of Metal Oxide Nanoparticles on Toll-Like Receptor mRNAs in Human Monocytes

Tanshinone IIA Attenuates Contrast-Induced Nephropathy via Nrf2 Activation in Rats

Potential Applications of Nanotechnology in Urological Cancer

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