Curarisation prolongée à la succinylcholine liée à un variant silencieux de la cholinestérase plasmatique

Ceppa, F.; Kenane, N.; Chellak, Saliha; Bigaillon, C.; Burnat, P.

doi:10.1016/j.annfar.2004.12.029

Cited by 11 publications

(1 citation statement)

References 3 publications

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“…This is because the BChE activity in patients with the K variant is indistinguishable from the patients with normal BChE, unless the K variant occurs in heterozygote combination with A or S variant. In a case report, one patient exhibiting a 5 hr succinylcholine-induced apnea was showed to be associated with homozygous S variant of BCHE gene [27].…”

Section: Butyrylcholinesterasementioning

confidence: 99%

Pharmacokinetic and Pharmacodynamic Variability: A Daunting Challenge in Drug Therapy

Lin¹

2007

CDM

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Patients vary considerably in their response to drug therapy. A drug that proves to be pharmacologically effective in some patients at a given dose may be ineffective or even toxic in others. The interindividual variability in drug response represents a major challenge in drug therapy, particularly for drugs with narrow therapeutic index. The intensity and duration of a drug action are determined not only by pharmacokinetic processes, but also by pharmacodynamic processes. Therefore, the variability in drug response is a result of the variability in either pharmacokinetic or pharmacodynamic processes, or a combination of both. The purpose of this paper is to review the sources that contribute to pharmacokinetic and pharmacodynamic variability. Although the main focus will be on the genetic variability, the impact of environmental factors on drug response will also be discussed. Finally, the application and limitation of the concept of personalized medicine will be briefly discussed.

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Section: Butyrylcholinesterasementioning

confidence: 99%

Pharmacokinetic and Pharmacodynamic Variability: A Daunting Challenge in Drug Therapy

Lin¹

2007

CDM

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A color‐reaction‐based rapid screening for null activity of butyrylcholinesterase: A step toward point‐of‐care screening for succinylcholine apnea

Nagpal

Chowdhary

Bhattacharyya

et al. 2015

Biotech and App Biochem

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Succinylcholine apnea happens in cases of null butyrylcholinesterase activity after administration of preintubation succinylcholine. So far, there is no such popular test that can rapidly screen null butyrylcholinesterase activity from plasma. Development of a novel method for rapid screening of null butyrylcholinesterase activity of plasma samples was the objective of the current work. Dichromate reagent was added to 1-naphthol, 2-naphthol, phenol, and para-nitrophenol in separate aliquots and watched for the color formation. Plasma samples preincubated with and without selective butyrylcholinesterase inhibitor were mixed with 1-naphthylacetate and watched for color development after addition of dichromate reagent. Fitting of 1-naphthylacetate at the active site of butyrylcholinesterase was analyzed by using tools of computational biology. It was seen that 1-naphthol formed color with dichromate reagent in a concentration-dependent manner. Other phenols did not form color with dichromate reagent even at 500-µm concentrations. Plasma sample with and without selective butyrylcholinesterase inhibitor (tetra isopropyl pyrophosphoramide) was distinguishable by color formation when incubated with 1-naphthylacetate, followed by the addition of dichromate reagent. In silico analysis also showed that 1-naphthylacetate fitted well at the active site of butyrylcholinesterase. The developed method may be used for rapid screening for null butyrylcholinesterase activity at point of care.

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Esterases

Lockridge

2010

Comprehensive Toxicology

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Curarisation prolongée à la succinylcholine liée à un variant silencieux de la cholinestérase plasmatique

Cited by 11 publications

References 3 publications

Pharmacokinetic and Pharmacodynamic Variability: A Daunting Challenge in Drug Therapy

Pharmacokinetic and Pharmacodynamic Variability: A Daunting Challenge in Drug Therapy

A color‐reaction‐based rapid screening for null activity of butyrylcholinesterase: A step toward point‐of‐care screening for succinylcholine apnea

Esterases

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