This study is to explore the effect of predictive nursing mode on preventing from bone cement implantation syndrome in hemiarthroplasty. 55 patients who were performed with bone cement hemiarthroplasty in our hospital from January 2018 to December 2018 were selected. These patients were divided into conventional group (n=25) and predictive nursing mode group (n=30) according to nursing modes. Then the systolic pressure (SBP), diastolic blood pressure (DBP), heart rate (HR) and oxyhemoglobin saturation (SpO 2 ) of the two groups of patients were compared 10min before injection of bone cement (T1), at the time of implantation of bone cement (T2), and 10min after injection of bone cement respectively (T3). The occurrence situation of respiratory distress, arrhythmia, dizziness, chest distress, panic, nausea, vomiting and shock for the two groups of patients in the surgery were compared. There was no significant difference for the comparison of the data including age, cardiac function, etc. of the patients between the conventional group and predictive nursing mode group. However, SBP and DBP of the intervention group at the time of T1, T2 and T3 were higher than that of the conventional group (P<0.05). Additionally, HR and SpO 2 of the intervention group at the time of T1, T2 and T3 were higher than that of the conventional group (P<0.05). As for the comparison of the evaluation indexes of bone cement for the two groups of patients in the surgery, the occurrence situation of hypotension, hyoxemia and RDS for the intervention group were apparently lower than that for the conventional group (P<0.05). As for the comparison of the intraoperative discomfort for the two groups of patients, the occurrence situation of dizziness, chest distress, panic, vomiting, nausea and shock of the intervention group were lower than that of the conventional group. The predictive nursing mode can be used for early intervention so as to relieve and avoid the occurrence of bone cement implantation syndrome in hemiarthroplasty, therefore it is worthy of being promoted for application. Suspected BCIS should be treated with aggressive resuscitation and supportive care. Prevention of BCIS includes identification of high-risk patients, preoperatively optimizing patient risk factors and comorbidities, and good communication with the surgical team.