Curative effect of endostar combined with oxaliplatin in the treatment of primary hepatic carcinoma and its influence on immune cells

Abstract

Curative effect and adverse reactions of oxaliplatin combined with endostar in the interventional treatment of primary hepatic carcinoma (PHC) were investigated. A total of 101 PHC patients from October 2012 to December 2014 in The First Affiliated Hospital of Xi'an Jiaotong University were retrospectively collected. Fifty patients in combined therapy group were treated with oxaliplatin combined with endostar, while the remaining 51 patients in oxaliplatin group were treated with oxaliplatin alone. The treatment lasted for a total of 4 cycles (20 days as 1 cycle). The ratios of cluster of differentiation 3 (CD3) + , CD4 + and CD8 + were detected via enzyme-linked immunosorbent assay (ELISA). The objective response rate in combined therapy group was 92.00%, which was significantly higher than that in oxaliplatin group (74.51%). The main adverse reactions showed no statistical difference between the two groups (P>0.05). The median progression-free survival (PFS) was 8.6 months in combined therapy group and 6.3 months in oxaliplatin group, while the median overall survival (OS) was 12.9 months in combined therapy group and 10.6 months in oxaliplatin group. After treatment, CD4 + and CD3 + levels in the peripheral blood in both groups were obviously lower than those before treatment, but the CD8 + level was obviously higher than that before treatment. At the same time, changes in the ratio of T lymphocyte subsets in combined therapy group were superior to those in oxaliplatin group, displaying statistically significant differences (P<0.05). Oxaliplatin combined with endostar has a good curative effect in the treatment of PHC with mild adverse reactions, which can prolong the survival time of patients, improve the levels of T lymphocyte subsets and increase the immunity of patients, so it is worthy of promotion and application in clinic.

Effects of transarterial chemoembolization on the immunological function of patients with hepatocellular carcinoma

“…Chronic hepatitis develops into cirrhosis and eventually leads to HCC. In China, which is one of the highly endemic countries, hepatitis B virus carriers account for 20% of the total population, with a 7–8% prevalence rate of hepatitis B ( 3 , 4 ). HCC has no specificity in the early stage and is a rapidly progressive disease ( 5 ).…”

“…HCC has no specificity in the early stage and is a rapidly progressive disease ( 5 ). Numerous patients are diagnosed in the middle and late stages, with poor therapeutic effects and prognosis ( 3 ).…”

“…Lei et al ( 3 ) compared the effects of oxaliplatin alone and oxaliplatin combined with endostar on the immune function of patients with primary liver cancer. Their study revealed that oxaliplatin combined with endostar was effective in prolonging patient survival time, improving T lymphocyte subgroup levels and enhancing patient immunity ( 3 ).…”

“…Lei et al ( 3 ) compared the effects of oxaliplatin alone and oxaliplatin combined with endostar on the immune function of patients with primary liver cancer. Their study revealed that oxaliplatin combined with endostar was effective in prolonging patient survival time, improving T lymphocyte subgroup levels and enhancing patient immunity ( 3 ). Ito et al ( 11 ) reported that RFA improved the efficacy of adaptive T cell therapy in murine models, and this can be supplemented by immunotherapy to achieve more effective results.…”

Improving the Therapeutic Efficacy of Sorafenib for Hepatocellular Carcinoma by Repurposing Disulfiram

“…Surgical interventions, including partial hepatectomy, liver transplantation, transarterial chemoembolization, and ablation, are effective in patients with early-stage HCC ( 3 ). However, most patients with HCC are diagnosed in the advanced stage, past the optimal time for surgical treatment ( 4 ). Therefore, systemic pharmacotherapy and radiotherapy play an important role in patients with advanced HCC, although they do not markedly improve the overall survival rate.…”