Curative Effects of Dianthus orientalis against Paracetamol Triggered Oxidative Stress, Hepatic and Renal Injuries in Rabbit as an Experimental Model

Ahmad, Bashir; Yousafzai, Ali Muhammad; Maria, Hafsa; Khan, Ayaz Ali; Aziz, Tariq; Alharbi, Metab; Alshammari, Abdulrahman; Alasmari, Abdullah F.

doi:10.3390/separations10030182

Cited by 15 publications

(13 citation statements)

References 47 publications

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“…GOLD was implemented to conduct a docking investigation for the target molecules (version 5.2) alongside its employment in the discovery studio. [57] After attaining the crystallized α-glucosidase, the H 2 O and inhibitors were removed, and the H atoms were added. The examined ligands were redocked into the vacant active site after the standard inhibitor was removed from it.…”

Section: α-Glucosidase Inhibitory Assaymentioning

confidence: 99%

Investigating Novel Thiophene Carbaldehyde Based Thiazole Derivatives as Potential Hits for Diabetic Management: Synthesis, In Vitro and In Silico Approach

Ullah,

Alam,

Zainab

et al. 2024

ChemistrySelect

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This research work is based on synthesis of eleven novel thiazole derivatives (3 a‐k) of thiophene carbaldehyde. All the synthesized compounds were successfully synthesized, characterized by 1H‐NMR and EI‐MS spectroscopic techniques and finally subjected for their in vitro α‐glucosidase inhibitory activity. Seven derivatives 3 i (IC50=10.21±1.84 μM), 3 b (IC50=11.14±0.99 μM), 3 f (IC50=13.21±2.76 μM), 3 h (IC50=14.21±0.31 μM), 3 k (IC50=15.21±1.02 μM), 3 e (IC50=16.21±1.32 μM), and 3 c (IC50=18.21±1.89 μM), in the series displayed excellent inhibitory potential better than the standard acarbose. However, two compounds 3 g (IC50=33.21±1.99 μM) and 3 d (IC50=42.31±2.12 μM) showed significant activity while two compounds 3 j and 3 a were found less active with IC50 values of 82.31±0.31 and 88.36±1.21 μM respectively. Additional research revealed that the compounds are not exhibiting any cytotoxic effects. The molecular docking study of these derivatives showed their good binding potential for α‐glucosidase active site with excellent interactions and docking scores.

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Section: α-Glucosidase Inhibitory Assaymentioning

confidence: 99%

Investigating Novel Thiophene Carbaldehyde Based Thiazole Derivatives as Potential Hits for Diabetic Management: Synthesis, In Vitro and In Silico Approach

Ullah,

Alam,

Zainab

et al. 2024

ChemistrySelect

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“…From centuries medicinal plants have been used for theurapeutic purposes as it contains plenty of potential bioactive compounds. Recently these plants have been under keen intrest of various researchers due to their potential health benefits (Zahra et al, 2024;Aziz et al, 2024;Riaz et al, 2023;Waqas et al, 2023;Ahmad et al, 2023a;Ahmad et al, 2023b;Ammara et al, 2023;Aqib et al, 2023;Ejaz et al, 2023;Aziz et al, 2023;Gul et al, 2023). Extracts of various medicinal plants are used in different industries such as pharmaceuticals, food industries and for nanomedicine (Hayat et al, 2023;Hussain et al, 2023;Iram et al, 2023;Riasat et al, 2023;Saleem et al, 2023;Sana et al, 2022;Syed et al, 2023;Zahra et al, 2023;Zawar et al, 2023;Rauf et al, 2023; Effect of maltodextrin concentration and drying temperature on the physicochemical characteristics of Sacha inchi Naveed et al, 2022a;Naveed et al, 202b).…”

Section: Introductionmentioning

confidence: 99%

Effect of maltodextrin concentration and drying temperature on the physicochemical characteristics of Sacha inchi (Plukenetia volubilis) extract powder

Hariadi,

Wahyono,

Darniadi

et al. 2024

Ital. J. Food Sci.

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Sacha inchi (Plukenetia volubilis L.) is an ancestral plant with various beneficial properties and has been used as a food source due to its high nutritional value for human health. The aim of this study was to assess the effect of the addition of maltodextrin concentration, the impact of the use of drying temperature, and the interaction of both on the physicochemical characteristics of powdered Sacha inchi extract. The results of this study would provide insightful information about the utilization of Sacha inchi, the optimal concentration of maltodextrin, and the drying temperature of powdered Sacha inchi extract. The experimental design used in this study is a Randomized Group Design with a 3x3 factorial pattern of two replications followed by Duncan’s further test. The observed variation consisted of maltodextrin concentration (5%, 10%, and 15%) and drying temperature (50⁰C, 60⁰C, and 70⁰C). This study includes chemical and physical responses such as moisture content, antioxidant activity, yield, solubility, hygroscopicity, and scanning electron microscopy (SEM). The effect of maltodextrin concentration and drying temperature factor was significant on moisture content, hygroscopicity, yield, and solubility. The interaction between drying temperature and maltodextrin concentration significantly affected moisture content and solubility.

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“…Recently, Dianthus crinitus has been reported for its ethno-pharmacological, anti-catarrhal, antipyretic, antispasmodic, bronchi dilatator, diuretic, expectorant, and diarrheal cure properties (Ahmad et al, 2023b;Ghamari et al, 2017). Thus, in the current study, Dianthus crinitus was selected for its analgesic and antioxidant activities in a selected animal model.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of analgesic, antioxidant, and anti-inflammatory potential of Dianthus crinitus using mice as a research animal

Ahmad,

Ali Khan,

Ur Rehman

et al. 2024

Ital. J. Food Sci.

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In the past, natural resources were used as best therapeutic sources for different diseases. Among several herbal resources, certain plant families are known for their analgesic activities, such as Dianthus crinitus, which showed a good curative potential. The mentioned plant has been used traditionally for the healing of several illnesses such as pain, inflammation, injuries, etc. The current study, therefore, evaluated the analgesic and anti-antioxidant activities of ethanolic extracts of leaves, flowers, and seeds of Dianthus crinitus in mice. For analgesic activity, acetic acid and a hot plate thermal stimulation method were used to induce writhes in mice, followed by a tail emersion process. Results showed that the extract demonstrated analgesic potential in mice, signifying both peripheral and central modes of action. Furthermore, extract also significantly inhibited the rat paw edema triggered by carrageenan seaweed and dextran as revealed by neutrophil migration toward the peritoneal cavities of animals and enhanced vascular permeability. The data suggested that the extract exhibited a dose-dependent antioxidant action. These preliminary observations provided support for further exploration and justification for the potential development of a new class of analgesic and anti-inflammatory medicines from the constituents of Dianthus crinitus extract.

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Curative Effects of Dianthus orientalis against Paracetamol Triggered Oxidative Stress, Hepatic and Renal Injuries in Rabbit as an Experimental Model

Cited by 15 publications

References 47 publications

Investigating Novel Thiophene Carbaldehyde Based Thiazole Derivatives as Potential Hits for Diabetic Management: Synthesis, In Vitro and In Silico Approach

Investigating Novel Thiophene Carbaldehyde Based Thiazole Derivatives as Potential Hits for Diabetic Management: Synthesis, In Vitro and In Silico Approach

Effect of maltodextrin concentration and drying temperature on the physicochemical characteristics of Sacha inchi (Plukenetia volubilis) extract powder

Evaluation of analgesic, antioxidant, and anti-inflammatory potential of Dianthus crinitus using mice as a research animal

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