Curative efficacy and safety of traditional Chinese medicine xuebijing injections combined with ulinastatin for treating sepsis in the Chinese population

Xiao, Shihui; Luo, Lun; Liu, Xianghong; Yang, Zhou; Li, Hongming; Huang, Zhenfei

doi:10.1097/md.0000000000010971

Cited by 24 publications

(39 citation statements)

References 6 publications

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“…Xuebijing injection, a patented TCM developed for the treatment of SARS in China, is indicated for infection-associated SIRS. The results of a meta-analysis of 16 papers, including 1335 cases of sepsis in a Chinese population, showed that, compared with ulinastatin alone, the combination of Xuebijing with ulinastatin led to a shorter mechanical ventilation time, shorter ICU stay, improved 28-day survival rate, reduced incidence of MODS and mortality, decreased procalcitonin concentration, ameliorated acute physiology and chronic health evaluation (APACHE) II score, and reduced levels of TNF-α and IL-6 ( 94 ). Xuebijing also exhibited antithrombotic activity, which could prevent vascular embolism caused by COVID-19 ( 91 ).…”

Section: Immunotherapy Strategies For Patients With Critically Ill Comentioning

confidence: 99%

Immunomodulation for Severe COVID-19 Pneumonia: The State of the Art

2020

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Section: Immunotherapy Strategies For Patients With Critically Ill Comentioning

confidence: 99%

Immunomodulation for Severe COVID-19 Pneumonia: The State of the Art

2020

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“…Rhubarb, astragalus, Polygonum cuspidatum, asiatica, motherwort , and Ligusticum chuanxiong and their effective extracts can significantly reduce the levels of various inflammatory factors such as TNF‐α and IL‐6, maintain redox reaction, promote the excretion of blood urea nitrogen (BUN) and serum creatinine (Scr), reduce the renal injury, and protect the renal function . TCM compounds, Qingwenbaidu and Xuebijing injection, control the excessive release of inflammatory factors and cytokines by clearing heat, detoxifying the blood circulation, removing the blood stasis, restoring the balance of pro‐inflammatory and anti‐inflammatory reactions, reducing the injury of tissues and organs to the maximum, and protecting the normal functions of the kidney .…”

Section: Therapeutic Principle Of Infectious Diseases In Tcmmentioning

confidence: 99%

Prevention and treatment of infectious diseases by traditional Chinese medicine: a commentary

Chen

Guo

et al. 2019

APMIS

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The present review aimed to summarize the effectiveness and features of traditional Chinese medicine (TCM) for the treatment of infectious diseases and to discuss the limitation of the development of TCM. The personalized medicine with TCM exerts a curative effect on viral and bacterial infectious diseases with unique advantages on the improvement of clinical manifestation, pathogen inhibition, and organ recovery during severe and drug‐resistant infection. The deficiency of personalized medicine with TCM lies in that the current research design of TCM primarily focuses on the study of the effective components and material basis of Chinese herbs at the cellular, molecular, and genetic level, while ignoring the guidance of the TCM syndrome differentiation theory, which is the core concept of individualized treatment. Personalized medicine with TCM has a broad prospective for infectious diseases due to the specific efficacy and advantages. While the curative effect of individualized treatment with TCM cannot be excluded from the TCM syndrome differentiation theory, the study of personalized medicine with TCM for infectious diseases urgently requires a unified standardization of the clinical syndrome differentiation and the evolution rule of infectious diseases by TCM theory.

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“…However, macrolide resistance has emerged worldwide with a significant increase, which increasingly lead to complex clinical treatment schemes . In recent years, with the increase of people’ recognition of traditional Chinese medicine, combining Chinese Medicine and Western Medicine to treat diseases has been an acceptable treatment method . This provides another idea to treat mycoplasma pneumonia in children.…”

Section: What Is Known and Objectivementioning

confidence: 99%

“…2,[11][12][13][14][15] In recent years, with the increase of people' recognition of traditional Chinese medicine, combining Chinese Medicine and Western Medicine to treat diseases has been an acceptable treatment method. 16,17 This provides another idea to treat mycoplasma pneumonia in children.…”

Section: What Is K Nown and Objec Tivementioning

confidence: 99%

Comparative efficacy of Chinese herbal injections combined with azithromycin for mycoplasma pneumonia in children: A Bayesian network meta‐analysis of randomized controlled trials

Duan

Wang

et al. 2019

J Clin Pharm Ther

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What is known and objectiveAn increasing macrolide resistance leads to complex clinical treatment schemes in mycoplasma pneumonia in children. Chinese herbal injection (CHI) is widely used to treat it and may provide a new treatment regimen. This study was conducted to systematically evaluate the efficacy of CHIs combined with azithromycin for treating mycoplasma pneumonia in children by Bayesian network meta‐analysis.MethodsRandomized controlled trials (RCTs) of CHIs combined with azithromycin for mycoplasma pneumonia in children were searched in electronic databases and related references from initiation to 30 October 2018. Two researchers conducted data extraction and risk of bias assessment. WinBUGS software and STATA software were adopted to analyse the data.ResultsA total of 167 RCTs were included with 5 CHIs involving 16 144 patients. All CHIs combined with azithromycin had superior effects than azithromycin only among overall outcomes. Yanhuning injection combined with azithromycin ranked highest in four different outcomes and second in two based on surface under the cumulative ranking probabilities (SUCRA). Meanwhile, the results of MD and 95% CIs of concerned outcomes indicated that only Yanhuning injection combined with azithromycin had better response than other CHIs combined with azithromycin. Moreover, cluster analysis results revealed Reduning injection combined with azithromycin was associated with a positive effect on the three group outcomes. Similarly, it was found to be the top three ranking in all outcomes based on SUCRA.What is new and conclusionYanhuning injection combined with azithromycin and Reduning injection combined with azithromycin were found to be preferable treatments based on the data of this study.

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Curative efficacy and safety of traditional Chinese medicine xuebijing injections combined with ulinastatin for treating sepsis in the Chinese population

Abstract: Supplemental Digital Content is available in the text

Cited by 24 publications

References 6 publications

Immunomodulation for Severe COVID-19 Pneumonia: The State of the Art

Immunomodulation for Severe COVID-19 Pneumonia: The State of the Art

Prevention and treatment of infectious diseases by traditional Chinese medicine: a commentary

Comparative efficacy of Chinese herbal injections combined with azithromycin for mycoplasma pneumonia in children: A Bayesian network meta‐analysis of randomized controlled trials

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