Curative Wedge Resection for Non-Invasive Bronchioloalveolar Carcinoma

Sagawa, Motoyasu; Higashi, Kõtarõ; Usuda, Katsuo; Aikawa, Hirokazu; Machida, Yuichiro; Tanaka, Makoto; Ueno, Masakatsu; Sakuma, Tsutomu

doi:10.1620/tjem.217.133

Cited by 9 publications

(4 citation statements)

References 20 publications

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“…Among these 31 unique studies, 25 categorised the PSN using lung windows only, reporting either (R1) or (1-R1) [48, 49, 54–79]. Two articles measured PSNs, one time using lung window settings only and the other time using both mediastinal and lung window settings [80, 81]; these two articles are included.…”

Section: Resultsmentioning

confidence: 99%

Controversies on lung cancers manifesting as part-solid nodules

Yip

Liu

et al. 2017

Eur Radiol

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Purpose Summarise survival of patients with resected lung cancers manifesting as part-solid nodules (PSNs). Methods PubMed/MEDLINE and EMBASE databases were searched for all studies/clinical trials on CT-detected lung cancer in English before 21 December 2015 to identify surgically resected lung cancers manifesting as PSNs. Outcome measures were lung cancer-specific survival (LCS), overall survival (OS), or disease-free survival (DFS). All PSNs were classified by the percentage of solid component to the entire nodule diameter into category PSNs <80% or category PSNs ≥80%. Results Twenty studies reported on PSNs <80%: 7 reported DFS and 2 OS of 100%, 6 DFS 96.3-98.7%, and 11 OS 94.7-98.9% (median DFS 100% and OS 97.5%). Twenty-seven studies reported on PSNs ≥80%: 1 DFS and 2 OS of 100%, 19 DFS 48.0%-98.0% (median 82.6%), and 16 reported OS 43.0%-98.0% (median DFS 82.6%, OS 85.5%). Both DFS and OS were always higher for PSNs <80%. Conclusion A clear definition of the upper limit of solid component of a PSN is needed to avoid misclassification because cell-types and outcomes are different for PSN and solid nodules. The workup should be based on the size of the solid component.

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Section: Resultsmentioning

confidence: 99%

Controversies on lung cancers manifesting as part-solid nodules

Yip

Liu

et al. 2017

Eur Radiol

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“… 19 20 21 Small persistent pure ground-glass nodules, particularly those smaller than 5 mm, often represent foci of AAH; in contrast, the larger the solid component of a lesion, the worse the prognosis. 22 23 24 25 26 27 28 29 Therefore, solitary subsolid nodules or dominant nodules among multiple subsolid nodules (solid component >5 mm) should be considered malignant and be recommended for transthoracic biopsy or surgical excision. 30 Considering the low diagnostic yield of transthoracic FNAB for subsolid nodules, transthoracic core needle biopsy or surgical excision would be better methods for tissue confirmation.…”

Section: Discussionmentioning

confidence: 99%

Predictors of False-Negative Results from Percutaneous Transthoracic Fine-Needle Aspiration Biopsy: An Observational Study from a Retrospective Cohort

et al. 2016

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PurposeWe investigated factors predictive of false-negative pulmonary lesions with nonspecific benign cytology results on percutaneous transthoracic fine-needle aspiration biopsy (FNAB).Materials and MethodsWe included 222 pulmonary lesions that had a nonspecific benign result from percutaneous transthoracic FNAB between March 2005 and December 2012, and were confirmed by subsequent pathologic results or adequate clinical follow up over at least 2 years. Clinical, imaging, and biopsy procedure-related findings were compared between lesions with a final diagnosis of malignancy (false-negative) and lesions with a benign diagnosis (true-negative). Multivariate logistic regression analysis was performed to identify significant predictors of false-negatives.ResultsOf 222 lesions, 115 lesions were proved to be false-negatives, and 107 were true-negatives. Compared with the true-negatives, false-negative lesions showed significantly older age (p=0.037), higher maximum standardized uptake value (SUVmax) on positron emission tomography (p=0.001), larger lesion size (p=0.007), and lesion characteristics of a subsolid nodule (p=0.007). On multivariate logistic regression analysis, SUVmax, lesion size, and lesion characteristics were significant predictors of false-negative results.ConclusionAmong the clinical, radiologic, and procedure-related factors analyzed, high SUVmax, large lesion size, and subsolid lesions were useful for predicting malignancy in pulmonary lesions with nonspecific benign cytology results on FNAB.

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“…Незважаючи на те, що є дані про 100 % або близький до цього рівня безрецидивний 5-річний період у разі атипової аденоматозної гіперплазії, аденокарциноми in situ та малоінвазивної аденокарциноми, при такому підході потрібні уточнені показання для хірургічного втручання [54]. Деякі автори є прибічниками обмеженої сублобарної резекції, зокрема крайової резекції та сегментектомії, у разі субсолідних СЛВ розміром  2 см замість лобектомії, обґрунтовуючи це відсутністю суттєвої різниці у виживаності та локальному метастазуванні [3,20,42,62]. Однак в останніх публікаціях зазначено, що у разі появи солідного компонента у СЛВ або його збільшенні за даними контрольної КТ ризик злоякісної природи утворення високий, тому потрібна його хірургічна резекція.…”

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Solitary focal lung lesions: modern views on the diagnosis and medical tactics of their management. Literature review

Liskina¹

2022

ТБ

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A review of the literature is devoted to highlighting of the main points relating to the modern actual multidisciplinary problem — single or solitary lung nodules with incidental detection. The main terms that are used in the study of such lesions or the more common term — nodules, as well as their definition are given. Known pathology causes for the development of solitary pulmonary nodules are also presented. The morphological characteristics of such nodules are described by X-ray or tomogram. The main problem if such nodules are detected is to establish their nature and, above all, their malignant or benign nature. Since the further medical tactic of their management are exactly different. Now the main attention is paid to malignant tumors, since they require the fastest most reliable identification and appropriate medical actions.It has been established that accurate determination of nodules etiology by the main indicators of their radiological images is impossible. Although certain dependences of the malignancy risk of nodules on their size, contours and features of optical density have been identified. And only a morphological study allows us to establish the true nature of the nodules. It is believed that over diagnostics of malignancy of pulmonary nodules leads to excessive use of expensive invasive diagnostic procedures, and to some extent harms the patient in cases of benign nodules. The review ends with a list of possible options for medical management when solitary lung nodules of unknown origin are detected. Their disadvantages and advantages are briefly presented.

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Curative Wedge Resection for Non-Invasive Bronchioloalveolar Carcinoma

Cited by 9 publications

References 20 publications

Controversies on lung cancers manifesting as part-solid nodules

Controversies on lung cancers manifesting as part-solid nodules

Predictors of False-Negative Results from Percutaneous Transthoracic Fine-Needle Aspiration Biopsy: An Observational Study from a Retrospective Cohort

Solitary focal lung lesions: modern views on the diagnosis and medical tactics of their management. Literature review

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