2013
DOI: 10.1016/j.mito.2012.07.104
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Curbing cancer's sweet tooth: Is there a role for MnSOD in regulation of the Warburg effect?

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Cited by 29 publications
(24 citation statements)
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References 333 publications
(365 reference statements)
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“…5F). Consistent with the role of the Warburg effect in the reported nuanced management of ROS in tumor cells [45, 46], our results indicate that CAFs may support this function by modulating the redox balance and enabling increased, stroma-mediated glycolysis in MDA-MB-231 cells.…”
Section: Resultssupporting
confidence: 88%
See 1 more Smart Citation
“…5F). Consistent with the role of the Warburg effect in the reported nuanced management of ROS in tumor cells [45, 46], our results indicate that CAFs may support this function by modulating the redox balance and enabling increased, stroma-mediated glycolysis in MDA-MB-231 cells.…”
Section: Resultssupporting
confidence: 88%
“…5E). While Nox-1 produces super oxide (SO), Mn-SOD scavenges SO radicals to produce H 2 O 2 , making Mn-SOD both a ROS producer and scavenger [44, 45]. Increased G6PD gene expression in MDA-MB-231 cells in response to CCM (Fig.…”
Section: Resultsmentioning
confidence: 99%
“…This mitochondrial enzyme converts the relatively short-lived superoxide anion radical to the more stable H 2 O 2 , which can traverse membranes and initiate redox signaling. SOD2 is overexpressed in some cancers but appears to function as a tumor suppressor in other types of cancer [14]. In DLBCL, a decreased level of SOD2 is associated with aggressive disease [41].…”
Section: Redox Homeostasis As a Chemotherapeutic Targetmentioning
confidence: 99%
“…Higher levels of ROS can independently signal cells to proliferate (Ogrunc et al, 2014; Wallace, 2012). MnSOD upregulates hypoxia inducible factor (HIF-1α) which helps cancer cells withstand the oxygen-poor environment created when the tumor grows but blood vessels have not yet infiltrated the new tumor (Holley, Dhar, & St Clair, 2013). Additionally, cancer cells favor a redox balance within the cell and will activate the transcription factor Nrf2, which upregulates the expression of antioxidant enzyme genes (van der Wijst, Brown, & Rots, 2014; Yang, Soga, & Pollard, 2013).…”
Section: Discussionmentioning
confidence: 99%