Curcuma as a functional food in the control of cancer and inflammation

Schaffer, Moshe; Schaffer, Pamela; Zidan, Jamal; Bar-Sela, Gil

doi:10.1097/mco.0b013e32834bfe94

Cited by 82 publications

(59 citation statements)

References 51 publications

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“…Curcumin also has anti-cancer effect at various stages such as tumor initiation, promotion, and progression in different types of cancers (Surh and Chun 2007). Several clinical trials with curcumin have shown positive effect on cancer prevention (Schaffer et al 2011). Curcumin also appeared to possess pharmacological activity to slow down the aging process and extend lifespan of Drosophila (Salvioli et al 2007;Sikora et al 2010;Suckow and Suckow 2006).…”

Section: Introductionmentioning

confidence: 99%

Curcumin-supplemented diets increase superoxide dismutase activity and mean lifespan in Drosophila

Shen

Xiao

Yuan

et al. 2012

AGE

119

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Curcumin is a polyphenolic bioactive compound in turmeric. We examined if antioxidant effects of curcumin are associated with lifespan extension in Drosophila. In this experiment, females and males of Drosophila were fed diets either containing no curcumin (C0) or supplemented with curcumin at 0.5 (C1) and 1.0 (C2) mg/g of diet. The levels of malondialdehyde (MDA), enzyme activity of superoxide dismutase AGE (2013) (SOD), and expression of seven age-related genes in females and males were analyzed. We found that C1 and C2 increased mean lifespan by 6.2 % and 25.8 % in females, and by 15.5 % and 12.6 % in males, respectively. Meanwhile, C1 and C2 significantly decreased MDA levels and increased SOD activity in both genders. Diets C1 in females and C2 in males are effective in extending mean lifespan and improving levels of two physiological and biochemical measures related to aging in Drosophila. Lifespan extension of curcumin in Drosophila was associated with the up-regulation of Mn-SOD and CuZn-SOD genes, and the downregulation of dInR, ATTD, Def, CecB, and DptB genes. The present results suggest that curcumin increases mean lifespan of Drosophila via regulating gene expression of the key enzyme SOD and reducing accumulation of MDA and lipid peroxidation. This study provided new insights for understanding the anti-aging mechanism of curcumin in Drosophila.

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Section: Introductionmentioning

confidence: 99%

Curcumin-supplemented diets increase superoxide dismutase activity and mean lifespan in Drosophila

Shen

Xiao

Yuan

et al. 2012

AGE

119

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“…Curcumin (diferuloylmethane) is polyphenolic compound derived from spices turmeric, a product of the plant curcuma longa [5]. The pigments responsible for yellow color of curcumin are phenolic in nature and are known by the name curcuminoids, which occur naturally in curcumin.…”

Section: Introductionmentioning

confidence: 99%

Structure-Function Elucidation of Antioxidative and Prooxidative Activities of the Polyphenolic Compound Curcumin

Malik

Mukherjee

2014

Chinese Journal of Biology

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Phenolic compounds have been very well known for their antioxidant properties, owing to their unique ability to act as free radical scavengers which, in turn, is an outstanding attribute of their unique biochemical structure. Recent accumulating lines of evidence inculcate sustainable interest and curiosity towards the chemoprotective nature of the natural polyphenolic compound curcumin (diferuloylmethane) against oxidative stress-mediated disorders. Curcumin is naturally found as a constituent of dietary spices called turmeric, extracted from the plant Curcuma longa. However, like every phenolic antioxidant, curcumin possesses a concentration and medium dependent anti-and pro-oxidant behaviour. A detailed study of the structure-function analysis and the understanding of the mode of action of curcumin as well as its chemical analogues is thus essential to understand the selective biochemical consequences of curcumin. Moreover, the presence of transition metal ions, route of administration, and localized tissue are also the vital decisive factors to determine curcumin behaviour. With this viewpoint, this paper sheds lights on the medium dependent prooxidative and antioxidative attributes of curcumin. Further, with respect to emergence of nanocarriers, a brief discussion focusing on the biochemical effect exertion of curcumin chiefly due to targeted and slow release has also been added towards the end.

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“…Curcumin, the principal polyphenolic cucuminoid, extracted from the turmeric rhizome Curcuma longa Linn, has been vastly reported for its biological activities, including anti-inflammatory (Schaffer et al, 2011), anti-oxidant (Speciale et al, 2011), anti-infection (Na et al, 2011) and anti-cancer (Bansal et al, 2011). Moreover, curcumin can cross the blood-brain barrier and is neuroprotective in neurological disorders (Song et al, 2012).…”

Section: Introductionmentioning

confidence: 99%

Curcumin Inhibits Human Non-small Cell Lung Cancer A549 Cell Proliferation Through Regulation of Bcl-2/Bax and Cytochrome C

Li¹,

Zhang²,

Geng³

et al. 2013

Asian Pacific Journal of Cancer Prevention

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We intended to study the mechanism of the inhibitory action of curcumin on human non-small cell lung cancer A549 cell. The cell growth was determined by CCK-8 assay, and the results indicated that curcumin inhibited the cell proliferation in a concentration dependent manner. And to further confirm the relative anti-cancer mechanism of curcumin, RT-PCR was carried out to analysis the expression of relative apoptotic proteins Bax, Bcl-2. We found that curcumin could up-regulate the expression of Bax but down-regulate the expression of Bcl-2 in A549 cells. In addition, curcumin affect the mitochondrial apoptosis pathway. These results suggested that curcumin inhibited cancer cell growth through the regulation of Bcl-2/Bax and affect the mitochondrial apoptosis pathway.

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Curcuma as a functional food in the control of cancer and inflammation

Cited by 82 publications

References 51 publications

Curcumin-supplemented diets increase superoxide dismutase activity and mean lifespan in Drosophila

Curcumin-supplemented diets increase superoxide dismutase activity and mean lifespan in Drosophila

Structure-Function Elucidation of Antioxidative and Prooxidative Activities of the Polyphenolic Compound Curcumin

Curcumin Inhibits Human Non-small Cell Lung Cancer A549 Cell Proliferation Through Regulation of Bcl-2/Bax and Cytochrome C

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