Curcuma as an anti-inflammatory component in treating osteoarthritis

Koroljević, Zrinka Djukić; Jordan, Katarina; Ivković, Jakov; Bender, Darija Vranešić; Perić, Porin

doi:10.1007/s00296-022-05244-8

Cited by 14 publications

(7 citation statements)

References 33 publications

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“…Previous research has demonstrated that curcumin, an anti-inflammatory compound, has a potential therapeutic effect in osteoarthritis (Koroljević et al, 2023 ). Our research results suggest that curcumin may play a role in the treatment of osteoarthritis by regulating the metabolic processes involving glycine, serine, and threonine.…”

Section: Discussionmentioning

confidence: 99%

Analysis of the mechanism of curcumin against osteoarthritis using metabolomics and transcriptomics

Deng,

He,

Zhang

2023

Naunyn-Schmiedeberg's Arch Pharmacol

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Curcumin, a polyphenolic compound derived from the turmeric plant (Curcuma longa), has been extensively studied for its anti-inflammatory and anti-proliferative properties. The safety and efficacy of curcumin have been thoroughly validated. Nevertheless, the underlying mechanism for treating osteoarthritis remains ambiguous. This study aims to reveal the potential mechanism of curcumin in treating osteoarthritis by using metabolomics and transcriptomics. Firstly, we validated the effect of curcumin on inflammatory factors in human articular chondrocytes. Secondly, we explored the cellular metabolism mechanism of curcumin against osteoarthritis using cell metabolomics. Thirdly, we assessed the differences in gene expression of human articular chondrocytes through transcriptomics. Lastly, to evaluate the essential targets and elucidate the potential mechanism underlying the therapeutic effects of curcumin in osteoarthritis, we conducted a screening of the proteins within the shared pathway of metabolomics and transcriptomics. Our results demonstrated that curcumin significantly decreased the levels of inflammatory markers, such as IL-β, IL-6, and TNF-α, in human articular chondrocytes. Cell metabolomics identified 106 differential metabolites, including beta-aminopropionitrile, 3-amino-2-piperidone, pyrrole-2-carboxaldehyde, and various other components. The transcriptomic analysis yielded 1050 differential mRNAs. Enrichment analysis showed that the differential metabolites and mRNAs were significantly enriched in seven pathways, including glycine, serine, and threonine metabolism; pentose and glucuronate interconversions; glycerolipid metabolism; histidine metabolism; mucin-type o-glycan biosynthesis; inositol phosphate metabolism; and cysteine and methionine metabolism. A total of 23 key targets were identified to be involved in these pathways. We speculate that curcumin may alleviate osteoarthritis by targeting key proteins involved in glycine, serine, and threonine metabolism; inhibiting pyruvate production; and modulating glycolysis.

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Section: Discussionmentioning

confidence: 99%

Analysis of the mechanism of curcumin against osteoarthritis using metabolomics and transcriptomics

Deng,

He,

Zhang

2023

Naunyn-Schmiedeberg's Arch Pharmacol

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“…There is no cure for osteoarthritis, but a number of pharmaceutical products can be used to relieve symptoms and slow progression (Pineda‐Moncusí et al, 2023). These remedies also include various dietary supplements, including those based on curcumin, which is also used to relieve the effects of rheumatoid arthritis (Koroljević et al, 2023). The analgesic effect of curcumin also helps relieve acute pain, including among patients who have not been diagnosed with osteoarthritis.…”

Section: Curcumin: a Brief Overviewmentioning

confidence: 99%

“…This property is compared to that of acetaminophen, so curcumin extract can become, in modern medicine, a viable alternative to nonsteroidal anti‐inflammatory drugs (Panknin et al, 2023). The symptoms that standardized curcumin extracts alleviate in arthritis are pain and inflammation (Koroljević et al, 2023). Due to its anti‐inflammatory properties, curcumin proves to be a good adjuvant in the treatment and prevention of these conditions.…”

Section: Curcumin: a Brief Overviewmentioning

confidence: 99%

Curcumin‐loaded nanomedicines as therapeutic strategy in malaria management

Amin,

Melody Devi,

Sarkar

et al. 2023

eFood

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Malaria, a parasitic protozoan disease widespread in tropical climates, is transmitted by Plasmodium spp. Many people are affected by this significant public health disease, which has a high incidence of illness and mortality worldwide. Because drug‐resistant parasites are on the rise, there are not enough controls on mosquitoes, and there are not any malaria vaccinations. Malaria is particularly challenging in developing countries. Antimalarial drugs approved by Food and Drug Administration are the main options for combating and preventing malaria; also the control of transmission at the level of mosquitoes is important. Current antimalarial chemotherapeutic therapies have significant clinical flaws such as Plasmodium resistance, the drugs that call for the development of novel drug candidates. To combat malaria, nanotechnology may give a viable alternative that is both more effective and safer than current treatment options. Nanotechnology‐based curcumin formulations have proved to overcome the limitations of current therapies in terms of optimum therapeutic benefits, safety, and cost‐efficiency, which increases a patient's capacity to adhere to prescribed medicine. The limits of current malaria therapies and the need to employ nanotechnological curcumin to treat malaria were addressed and discussed in this paper.

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“…Osteoarthritis (OA) is a chronic degenerative joint disease, featured by articular cartilage erosion, chronic joint pain, joint deformation, and even disability 1 . It has been reported that OA affects about 12% of elderly individuals, 2 and its incidence is increasing around the world 3 . Abnormal chondrocyte apoptosis and defect in extracellular matrix (ECM) homeostasis have been recognized to participate in OA pathogenesis 4 .…”

Section: Introductionmentioning

confidence: 99%

“…1 It has been reported that OA affects about 12% of elderly individuals, 2 and its incidence is increasing around the world. 3 Abnormal chondrocyte apoptosis and defect in extracellular matrix (ECM) homeostasis have been recognized to participate in OA pathogenesis. 4 Currently, the therapeutic approaches for OA are conservative treatments, including pain relief and anti-inflammatory drugs.…”

mentioning

confidence: 99%

SKP2‐mediated ubiquitination and degradation of KLF11 promotes osteoarthritis via modulation of JMJD3/NOTCH1 pathway

Huang,

Pan,

2024

The FASEB Journal

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Osteoarthritis (OA) is the main cause of cartilage damage and disability. This study explored the biological function of S‐phase kinase‐associated protein 2 (SKP2) and Kruppel‐like factor 11 (KLF11) in OA progression and its underlying mechanisms. C28/I2 chondrocytes were stimulated with IL‐1β to mimic OA in vitro. We found that SKP2, Jumonji domain‐containing protein D3 (JMJD3), and Notch receptor 1 (NOTCH1) were upregulated, while KLF11 was downregulated in IL‐1β‐stimulated chondrocytes. SKP2/JMJD3 silencing or KLF11 overexpression repressed apoptosis and extracellular matrix (ECM) degradation in chondrocytes. Mechanistically, SKP2 triggered the ubiquitination and degradation of KLF11 to transcriptionally activate JMJD3, which resulted in activation of NOTCH1 through inhibiting H3K27me3. What's more, the in vivo study found that KLF11 overexpression delayed OA development in rats via restraining apoptosis and maintaining the balance of ECM metabolism. Taken together, ubiquitination and degradation of KLF11 regulated by SKP2 contributed to OA progression by activation of JMJD3/NOTCH1 pathway. Our findings provide promising therapeutic targets for OA.

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Curcuma as an anti-inflammatory component in treating osteoarthritis

Cited by 14 publications

References 33 publications

Analysis of the mechanism of curcumin against osteoarthritis using metabolomics and transcriptomics

Analysis of the mechanism of curcumin against osteoarthritis using metabolomics and transcriptomics

Curcumin‐loaded nanomedicines as therapeutic strategy in malaria management

SKP2‐mediated ubiquitination and degradation of KLF11 promotes osteoarthritis via modulation of JMJD3/NOTCH1 pathway

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