Curcuma longa L. Rhizome Essential Oil from Extraction to Its Agri-Food Applications. A Review

Ibáñez, María Dolores; Blázquez, María Amparo

doi:10.3390/plants10010044

Cited by 73 publications

(44 citation statements)

References 219 publications

(278 reference statements)

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“…There is also an increasing interest in curcumin oil for its protective roles in cardiovascular disorders by lowering the total blood cholesterol and low-density lipoprotein levels [ 15 ]. The essential oil extracted from the rhizomes of Curcuma longa has been reported to have favorable characteristics for human consumption [ 16 ]. Self-nanoemulsifying drug delivery system (SNEDDS) is a promising approach to enhance the absorption of poorly water-soluble drugs [ 17 ].…”

Section: Introductionmentioning

confidence: 99%

Development of Multi-Compartment 3D-Printed Tablets Loaded with Self-Nanoemulsified Formulations of Various Drugs: A New Strategy for Personalized Medicine

et al. 2021

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This work aimed to develop a three-dimensional printed (3DP) tablet containing glimepiride (GLMP) and/or rosuvastatin (RSV) for treatment of dyslipidemia in patients with diabetes. Curcumin oil was extracted from the dried rhizomes of Curcuma longa and utilized to develop a self-nanoemulsifying drug delivery system (SNEDDS). Screening mixture experimental design was conducted to develop SNEDDS formulation with a minimum droplet size. Five different semi-solid pastes were prepared and rheologically characterized. The prepared pastes were used to develop 3DP tablets using extrusion printing. The quality attributes of the 3DP tablets were evaluated. A non-compartmental extravascular pharmacokinetic model was implemented to investigate the in vivo behavior of the prepared tablets and the studied marketed products. The optimized SNEDDS, of a 94.43 ± 3.55 nm droplet size, was found to contain 15%, 75%, and 10% of oil, polyethylene glycol 400, and tween 80, respectively. The prepared pastes revealed a shear-thinning of pseudoplastic flow behavior. Flat-faced round tablets of 15 mm diameter and 5.6–11.2 mm thickness were successfully printed and illustrated good criteria for friability, weight variation, and content uniformity. Drug release was superior from SNEDDS-based tablets when compared to non-SNEDDS tablets. Scanning electron microscopy study of the 3DP tablets revealed a semi-porous surface that exhibited some curvature with the appearance of tortuosity and a gel porous-like structure of the inner section. GLMP and RSV demonstrated relative bioavailability of 159.50% and 245.16%, respectively. Accordingly, the developed 3DP tablets could be considered as a promising combined oral drug therapy used in treatment of metabolic disorders. However, clinical studies are needed to investigate their efficacy and safety.

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Section: Introductionmentioning

confidence: 99%

Development of Multi-Compartment 3D-Printed Tablets Loaded with Self-Nanoemulsified Formulations of Various Drugs: A New Strategy for Personalized Medicine

et al. 2021

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“…In addition, several investigations carried out with the main components in plants of this family have demonstrated their antioxidant capacity against the DPPH radical in comparison with Trolox and ascorbic acid-among the most important ones are α-turmerone, β-turmerone, and Ar-turmerone [62]. In an investigation to evaluate the hepatoprotective effect of an extract of Amomum cardamomum on carbon-tetrachloride-induced liver damage through antioxidant activity in rats, it was found to possess significant hepatoprotective activity on acute liver injury, which could be derived from its antioxidant properties and the decrease of liver cytochrome P450 [63].…”

Section: Discussionmentioning

confidence: 99%

Benefits of Cardamom (Elettaria cardamomum (L.) Maton) and Turmeric (Curcuma longa L.) Extracts for Their Applications as Natural Anti-Inflammatory Adjuvants

Garza

Elizondo-Luévano

Bazaldúa-Rodríguez

et al. 2021

Plants

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The genus Zingiberaceae has been widely used for phytotherapeutic purposes in traditional medicine throughout the world for its anti-inflammatory activity. Experimental studies have established that inflammation caused by chronic infections represents a risk factor for different forms of cancer. The objective of this study was focused on determining the anti-inflammatory capacity and cytotoxic activity of aqueous extracts of Elettaria cardamomum (cardamom) and Curcuma Longa (turmeric). The extracts were obtained by maceration and, through GC-MS/MS, a total of 11 different chemical components were determined in the aqueous extract of cardamom and 7 in the extract of turmeric. The main compounds found in cardamom and turmeric were α-terpinyl acetate (54.46%) and β-turmerone (33.45%), respectively. RT-qPCR results showed significantly lower gene expression levels of innate inflammatory cytokines (IL-6 and TNF-α) compared to the control (LPS). Also, it was observed that the extracts do not possess cytotoxic activity against different cell lines, where E. cardamomum showed EC50 (µg/mL) of 473.84 (HeLa cells), 237.36 (J774A.1 cells), 257.51 (Vero E6 cells), and 431.16 (Balb/C peritoneal cells) and C. longa showed EC50 (µg/mL) of 351.17 (HeLa cells), 430.96 (J774A.1 cells), 396.24 (Vero E6 cells), and 362.86 (Balb/C peritoneal cells). The results of this research suggest that natural extracts of E. cardamomum and C. longa possess anti-inflammatory effects and no cytotoxic activity against HeLa, J774A.1, Vero E6, and Balb/C peritoneal cell lines, Finally, it was observed that the extracts also decreased nitric oxide (NO) production in peritoneal macrophages.

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“…It also has beneficial effects on several chronic disease states linked with inflammation and oxidative stress, as observed in DM and cancer [112]. Recently, it was reported that CUR inhibits the COVID-19 protease enzyme [113]. One proposed mechanism of CUR ameliorating DM is related to its antihyperlipidemic activity via suppression of fatty-acid synthase, carnitine palmitoyltransferase 1, 3-hydroxy-3-methyl glutaryl coenzyme A reductase, and acyl-CoA cholesterol acyltransferase enzymes [114].…”

Section: Curcumin (Cur)mentioning

confidence: 99%

Therapeutic Screening of Herbal Remedies for the Management of Diabetes

2021

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The study of diabetes mellitus (DM) patterns illustrates increasingly important facts. Most importantly, they include oxidative stress, inflammation, and cellular death. Up to now, there is a shortage of drug therapies for DM, and the discovery and the development of novel therapeutics for this disease are crucial. Medicinal plants are being used more and more as an alternative and natural cure for the disease. Consequently, the objective of this review was to examine the latest results on the effectiveness and protection of natural plants in the management of DM as adjuvant drugs for diabetes and its complex concomitant diseases.

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Curcuma longa L. Rhizome Essential Oil from Extraction to Its Agri-Food Applications. A Review

Cited by 73 publications

References 219 publications

Development of Multi-Compartment 3D-Printed Tablets Loaded with Self-Nanoemulsified Formulations of Various Drugs: A New Strategy for Personalized Medicine

Development of Multi-Compartment 3D-Printed Tablets Loaded with Self-Nanoemulsified Formulations of Various Drugs: A New Strategy for Personalized Medicine

Benefits of Cardamom (Elettaria cardamomum (L.) Maton) and Turmeric (Curcuma longa L.) Extracts for Their Applications as Natural Anti-Inflammatory Adjuvants

Therapeutic Screening of Herbal Remedies for the Management of Diabetes

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