Curcuma longa (Turmeric): Ethnomedicinal uses, phytochemistry, pharmacological activities and toxicity profiles—A review

Iweala, E. E. J.; Uche, Miracle Ebubechi; Dike, Emmanuel Dike; Etumnu, Lotanna Richard; Dokunmu, Titilope M.; Oluwapelumi, Adurosakin E.; Okoro, Benedict Chukwuebuka; Dania, Omoremime E.; Adebayo, Abiodun Humphrey; Ugbogu, Eziuche Amadike

doi:10.1016/j.prmcm.2023.100222

Cited by 53 publications

(17 citation statements)

References 137 publications

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“…Its leaves contain several beneficial secondary metabolites, including chrysophanol, aloin, and aloe-emodin. Aloin has been shown to inhibit the activity of phospholipase A2 120 , an enzyme that is responsible for the toxic effects of snake venom. In addition, aloe emodin has been shown to inhibit the activity of hyaluronidase (Figure 14), an enzyme that is involved in the spread of venom through the body.…”

Section: Phytochemical Constituents and Its Medicinal Propertiesmentioning

confidence: 99%

Venom Vanquish: A Comprehensive Review on Ethnobotany and Phytochemistry of Significant Traditional Medicinal Plants

T. Dhanya,

Kavinila,

David Paul Raj

2024

JNR

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Snakebite is a significant public health concern in many parts of the world, particularly in regions where venomous snakes are prevalent. Snakebites can range from mild to life-threatening, depending on the species of snake, the amount of venom injected, and the location of the bite. Globally, an estimated 5 million people are affected by snake bites each year, according to recent statistics. Since ancient times, traditional medicinal plants have been used to cure a wide range of illnesses, including snake bites. Secondary metabolites contained in plants were efficient in reducing the effects of snake venom. Snake venom is a potent toxin that can cause severe damage to the human body, affecting the nervous system, cardiovascular system, or both. Symptoms can range from mild swelling to life-threatening paralysis, respiratory failure, and hemorrhage. Enzyme activity is inhibited by flavonoids, alkaloids, and tannins, which additionally hinder blood from clotting and lessen inflammation. Treatments for snake bites that are more beneficial and less hazardous could result from the isolation and synthesis of natural drugs. With the use of cutting-edge scientific methods, we can maximize their potential and use their secondary metabolites to develop novel medications and therapies. The study of these plants and their potential uses in contemporary medicine requires more funding and investigation. This will advance our knowledge of these plants and help us create cures for some of the most lethal diseases.

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Section: Phytochemical Constituents and Its Medicinal Propertiesmentioning

confidence: 99%

Venom Vanquish: A Comprehensive Review on Ethnobotany and Phytochemistry of Significant Traditional Medicinal Plants

T. Dhanya,

Kavinila,

David Paul Raj

2024

JNR

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“…Natural compounds can have pesticide activity, making them attractive for further studies as environmental-friendly alternatives to chemical pesticides (Batish et al, 2008: Duke et al, 1990Schmutterer, 1990). Turmeric (Curcuma longa) is a spice that is native to southeast Asia and is used worldwide as a medicinal plant, food colouring agent, and an ingredient in supplements (Gupta et al, 2013;Iweala et al, 2023). Studies have shown that turmeric is toxic to insects, making this compound a candidate as natural pest control agent (Hellfeld et al, 2023;Raje et al, 2015;Uysal et al, 2015;Damalas, 2011, De Souza Tavares et al, 2016.…”

Section: Introductionmentioning

confidence: 99%

Turmeric shortens lifespan in houseflies

Laurie,

Ainslie,

Mitchell

et al. 2024

Preprint

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Climate change poses a significant threat to food security and global public health with the increasing likelihood of insect pest outbreaks. Alternative ways to control insect populations, preferably using environmental-friendly compounds, are needed. Turmeric has been suggested as a natural insecticide with toxicity properties in some insect groups. However, empirical evidence of the effects turmeric - and their interaction with other ecological factors such as diet - on insect survival has been limited. Here, we tested the effects of turmeric and its interactions with diets differing in protein source in the common housefly, Musca domestica. We found that turmeric shortened lifespan independent of diet and sex. Females in turmeric diets were heavier at death, which was likely driven by a combination of relatively lower rates of body mass loss during their lifetime and a higher percentage of water content at death. Each sex responded differently to the protein source in the diet, and the magnitude of the difference in lifespan between sexes were greatest in diets in which protein source was hydrolysed yeast; individuals from both sexes lived longest in sucrose-milk diets and shortest in diets with hydrolysed yeast. There was no evidence of an interaction between turmeric and diet, suggesting that the toxicity effects are independent of protein source in the diet. Given the seemingly opposing effects of turmeric in insects and mammals being uncovered in the literature, our findings provide further evidence in support of turmeric as a potential natural insecticide.

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“…Natural compounds can have pesticide activity, making them attractive for further studies as environmental-friendly alternatives to chemical pesticides ( 9 – 11 ). Turmeric ( Curcuma longa ) is a spice that is native to southeast Asia and is used worldwide as a medicinal plant, food colouring agent, and an ingredient in supplements ( 12 , 13 ). Studies have shown that turmeric is toxic to insects, likely in part due to its main compound, curcumin, making this spice a candidate as natural pest control agent ( 14 – 18 ).…”

Section: Introductionmentioning

confidence: 99%

Turmeric shortens lifespan in houseflies

Laurie,

Ainslie,

Mitchell

et al. 2024

Front. Insect Sci.

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Climate change poses a significant threat to food security and global public health with the increasing likelihood of insect pest outbreaks. Alternative ways to control insect populations, preferably using environmental-friendly compounds, are needed. Turmeric has been suggested as a natural insecticide with toxicity properties in some insect groups. However, empirical evidence of the effects of turmeric – and their interaction with other ecological factors such as diet – on insect survival has been limited. Here, we tested the effects of turmeric and its interactions with diets differing in protein source in the common housefly, Musca domestica. We found that turmeric shortened lifespan independent of diet and sex. Females in turmeric diets were heavier at death, which was likely driven by a combination of relatively lower rates of body mass loss during their lifetime and a higher percentage of water content at death. Each sex responded differently to the protein source in the diet, and the magnitude of the difference in lifespan between sexes were greatest in diets in which protein source was hydrolysed yeast; individuals from both sexes lived longest in sucrose-milk diets and shortest in diets with hydrolysed yeast. There was no evidence of an interaction between turmeric and diet, suggesting that the toxicity effects are independent of protein source in the diet. Given the seemingly opposing effects of turmeric in insects and mammals being uncovered in the literature, our findings provide further evidence in support of turmeric as a potential natural insecticide.

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Curcuma longa (Turmeric): Ethnomedicinal uses, phytochemistry, pharmacological activities and toxicity profiles—A review

Cited by 53 publications

References 137 publications

Venom Vanquish: A Comprehensive Review on Ethnobotany and Phytochemistry of Significant Traditional Medicinal Plants

Venom Vanquish: A Comprehensive Review on Ethnobotany and Phytochemistry of Significant Traditional Medicinal Plants

Turmeric shortens lifespan in houseflies

Turmeric shortens lifespan in houseflies

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