2022
DOI: 10.3390/molecules27072101
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Curcuma phaeocaulis Inhibits NLRP3 Inflammasome in Macrophages and Ameliorates Nanoparticle-Induced Airway Inflammation in Mice

Abstract: The activation of NLRP3 results in the assembly of inflammasome that regulates caspase-1 activation and the subsequent secretion of bioactive interleukin (IL)-1β. Excessive activation of the NLRP3 inflammasome is mechanistically linked to diverse pathophysiological conditions, including airway inflammation. Here, we discovered that Curcuma phaeocaulis can suppress caspase-1 activation and processing of pro-IL-1β into mature cytokine in macrophages stimulated with NLRP3 inflammasome activators, such as SiO2 or … Show more

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Cited by 11 publications
(8 citation statements)
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“…IL-1β levels were reduced in bronchoalveolar lavage (BAL) fluids from animals previously treated with nanoparticles and treated in vitro with C. phaeocaulis . C. phaeocaulis has an anti-inflammatory effect against lung disease associated with excessive activation of the NLRP3 inflammasome/inflammation [ 61 , 62 ].…”
Section: Curcumin Inflammasome and Lungmentioning
confidence: 99%
“…IL-1β levels were reduced in bronchoalveolar lavage (BAL) fluids from animals previously treated with nanoparticles and treated in vitro with C. phaeocaulis . C. phaeocaulis has an anti-inflammatory effect against lung disease associated with excessive activation of the NLRP3 inflammasome/inflammation [ 61 , 62 ].…”
Section: Curcumin Inflammasome and Lungmentioning
confidence: 99%
“…Furthermore, there is evidence that the downregulation of HK1 by 2-DG significantly suppressed the NLRP3/caspase-1/IL-lβ axis. Targeting NLRP3/caspase-1/IL-lβ pathway has been suggested as a potential therapeutic strategy for treating inflammatory diseases (Nam et al, 2022). Thus, a new insight targeting HK1 to alleviate the inflammatory response in AP is provided.…”
Section: Discussionmentioning
confidence: 99%
“…Curcumin reduces in ammation by inhibiting lipopolysaccharide-induced nuclear factor-κB (NF-κB) p65 translocation and mitogen-activated protein kinase activation in dendritic cells. In several studies, Curcumin has been shown to inhibit NLRP3 in ammasome activation in various models and culture mediums [19,20]. TLR4/MyD88/NF signalling and P2X7R expression are dual downregulated by curcumin, and this inhibits NLRP3-induced release of IL-1β and Caspase-1 [21].…”
Section: Introductionmentioning
confidence: 99%