Curcumagalactomannoside/Glucosamine Combination Improved Joint Health Among Osteoarthritic Subjects as Compared to Chondroitin Sulfate/Glucosamine: Double-Blinded, Randomized Controlled Study

Khanna, Aman; Das, Sivadasan Syam; Smina, T P; Thomas, Jestin V.; Kunnumakkara, Ajaikumar B.; Maliakel, Balu; Krishnakumar, I. M.; Mohanan, Ratheesh

doi:10.1089/acm.2020.0128

Cited by 22 publications

(20 citation statements)

References 65 publications

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“…Nine RCTs did not described the random sequence generation methods and were rated as unclear risk of bias (39,40,44,49,51,54,60,(63)(64)(65). Other studies have explained the method of generating random sequences, so they are assessed as low risk of bias.…”

Section: Selection Biasmentioning

confidence: 99%

Efficacy and Safety of Curcumin and Curcuma longa Extract in the Treatment of Arthritis: A Systematic Review and Meta-Analysis of Randomized Controlled Trial

Zeng

Yang

et al. 2022

Front. Immunol.

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BackgroundModern pharmacological research found that the chemical components of Curcuma longa L. are mainly curcumin and turmeric volatile oil. Several recent randomized controlled trials (RCT) have shown that curcumin improves symptoms and inflammation in patients with arthritis.MethodsPubmed, Cochran Library, CNKI, and other databases were searched to collect the randomized controlled trials (RCTs). Then, the risk of bias of RCTs were assessed and data of RCTs were extracted. Finally, RevMan 5.3 was utilized for meta-analysis.ResultsTwenty-nine (29) RCTs involving 2396 participants and 5 types of arthritis were included. The arthritis included Ankylosing Spondylitis (AS), Rheumatoid Arthritis (RA), Osteoarthritis (OA), Juvenile idiopathic arthritis (JIA) and gout/hyperuricemia. Curcumin and Curcuma longa Extract were administered in doses ranging from 120 mg to 1500 mg for a duration of 4-36 weeks. In general, Curcumin and Curcuma longa Extract showed safety in all studies and improved the severity of inflammation and pain levels in these arthritis patients. However, more RCTs are needed in the future to elucidate the effect of Curcumin and Curcuma longa Extract supplementation in patients with arthritis, including RA, OA, AS and JIA.ConclusionCurcumin and Curcuma longa Extract may improve symptoms and inflammation levels in people with arthritis. However, due to the low quality and small quantity of RCTs, the conclusions need to be interpreted carefully.

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Section: Selection Biasmentioning

confidence: 99%

Efficacy and Safety of Curcumin and Curcuma longa Extract in the Treatment of Arthritis: A Systematic Review and Meta-Analysis of Randomized Controlled Trial

Zeng

Yang

et al. 2022

Front. Immunol.

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“…After screening the titles and abstracts of the remaining 263 citations, we excluded 233 irrelevant records based on the selection criteria. Thirty studies were remained for full-text assessment, eleven studies were excluded because of ineligible interventions, including the combination of glucosamine hydrochloride, chondroitin sulphate and curcumin [ 41 ], curcumagalactomannoside complex [ 42 , 43 ], CURs combined with diclofenac [ 44 , 45 ], herbal formulations of different extracts [ 46 – 50 ], and CURs-free CL extracts [ 51 ]. Furthermore, we excluded four conference abstracts [ 52 – 55 ] due to incomplete data.…”

Section: Resultsmentioning

confidence: 99%

Efficacy and safety of curcuminoids alone in alleviating pain and dysfunction for knee osteoarthritis: a systematic review and meta-analysis of randomized controlled trials

Feng

Tian

et al. 2022

BMC Complement Med Ther

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Background Curcuminoids (CURs) are the principal ingredients of Curcuma longa L. [Zingiberaceae] (CL)—an herbal plant used in east Asia to alleviate pain and inflammation. Thus far, the therapeutic effects of CURs for knee osteoarthritis (OA) uncovered by multiple reviews remained uncertain due to broadly involving trials with different agents-combined or CURs-free interventions. Therefore, we formed stringent selection criteria and assessment methods to summarize current evidence on the efficacy and safety of CURs alone in the treatment of knee OA. Methods A series of databases were searched for randomized controlled trials (RCTs) evaluating the efficacy and safety of CURs for knee OA. Clinical outcomes were evaluated using meta-analysis and the minimum clinically important difference (MCID) for both statistical and clinical significance. Results Fifteen studies with 1670 patients were included. CURs were significantly more effective than placebo in the improvements of VAS for pain ( WMD: − 1.77, 95% CI: − 2.44 to − 1.09), WOMAC total score ( WMD: − 7.06, 95% CI: − 12.27 to − 1.84), WOMAC pain score ( WMD: − 1.42, 95% CI: − 2.41 to − 0.43), WOMAC function score ( WMD: − 5.04, 95% CI: − 7.65 to − 2.43), and WOMAC stiffness score ( WMD: − 0.54, 95% CI: − 1.03 to − 0.05). Meanwhile, CURs were not inferior to NSAIDs in the improvements of pain- and function-related outcomes. Additionally, CURs did not significantly increase the incidence of adverse events (AEs) compared with placebo ( RR: 1.03, 95% CI: 0.69 to 1.53, P = 0.899, I2 = 23.7%) and NSAIDs (RR: 0.71 0.65, 95% CI: 0.57 0.41 to 0.90 1.03). Conclusions CURs alone can be expected to achieve considerable analgesic and functional promotion effects for patients with symptomatic knee OA in short term, without inducing an increase of adverse events. However, considering the low quality and substantial heterogeneity of present studies, a cautious and conservative recommendation for broader clinical use of CURs should still be made. Further high-quality studies are necessary to investigate the impact of different dosages, optimization techniques and administration approaches on long-term safety and efficacy of CURs, so as to strengthen clinical decision making for patients with symptomatic knee OA.

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“…After screening the titles and abstracts of the remaining 291 citations, we excluded 262 irrelevant records based on the selection criteria. Twentynine studies were remained for full-text assessment, eleven studies were excluded because of ineligible interventions, including the combination of glucosamine hydrochloride, chondroitin sulphate and curcumin [42], curcumagalactomannoside complex [43,44], CURs combined with diclofenac [45,46], herbal formulations of different extracts [47][48][49][50][51], and CURs-free CL extracts [52]. Furthermore, we excluded four conference abstracts [53][54][55][56] due to incomplete data.…”

Section: Literature Search Resultsmentioning

confidence: 99%

Clinical Significance of Curcuminoids Alone in Alleviating Pain and Dysfunction for Knee Osteoarthritis: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

Feng

Tian

et al. 2022

Preprint

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Background: Curcuminoids (CURs) are the principal ingredients of Curcuma longa L. [Zingiberaceae] (CL)—an herbal plant used in east Asia to alleviate pain and inflammation. Thus far, the therapeutic effects of CURs for knee osteoarthritis (OA) uncovered by multiple reviews remained uncertain due to broadly involving trials with different agents-combined or CURs-free interventions. Therefore, we formed stringent selection criteria and assessment methods to summarize current evidence on the effectiveness of CURs alone in the treatment of knee OA.Methods: A series of databases were searched for randomized controlled trials (RCTs) evaluating the efficacy of CURs for knee OA. Clinical outcomes were evaluated using meta-analysis and the minimum clinically important difference (MCID) for both statistical and clinical significance.Results: Fourteen studies with 1633 patients were included. Overall, CURs were significantly more effective than controls in the improvements of VAS for pain (WMD: −1.46, 95% CI: −2.13 to −0.8), WOMAC total score (WMD: −7.06, 95% CI: −12.27 to −1.84), WOMAC pain score (WMD: −1.42, 95% CI: −2.41 to −0.43), WOMAC function score (WMD: −5.04, 95% CI: −7.65 to −2.43), but not in WOMAC stiffness score (WMD: −0.34, 95% CI: −0.79 to 0.1). Moreover, the effect sizes of VAS for pain and WOMAC total score exceeded their MCID, while WOMAC subscale scores did not. Additionally, CURs did not significantly increase the incidence of adverse events (AEs) compared with placebo (RR: 1.22, 95% CI: 0.89 to 1.67), and significantly lowered the incidence of AEs when compared with NSAIDs (RR: 0.71, 95% CI: 0.59 to 0.9).Conclusions: CURs alone can be expected to achieve considerable analgesic and functional promotion effects for patients with symptomatic knee OA in short term, without inducing an increase of adverse events. However, considering the low quality and substantial heterogeneity of present studies, a cautious and conservative recommendation for broader clinical use of CURs should still be made. Further high-quality studies are necessary to investigate the impact of different dosages, optimization techniques and administration approaches on long-term safety and efficacy of CURs, so as to strengthen clinical decision making for patients with symptomatic knee OA.

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Curcumagalactomannoside/Glucosamine Combination Improved Joint Health Among Osteoarthritic Subjects as Compared to Chondroitin Sulfate/Glucosamine: Double-Blinded, Randomized Controlled Study

Cited by 22 publications

References 65 publications

Efficacy and Safety of Curcumin and Curcuma longa Extract in the Treatment of Arthritis: A Systematic Review and Meta-Analysis of Randomized Controlled Trial

Efficacy and Safety of Curcumin and Curcuma longa Extract in the Treatment of Arthritis: A Systematic Review and Meta-Analysis of Randomized Controlled Trial

Efficacy and safety of curcuminoids alone in alleviating pain and dysfunction for knee osteoarthritis: a systematic review and meta-analysis of randomized controlled trials

Clinical Significance of Curcuminoids Alone in Alleviating Pain and Dysfunction for Knee Osteoarthritis: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

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