Curcumenol improves renal function in 5/6 nephrectomy‐induced chronic renal failure rats via the SIRT1/NF‐κB pathway

Abstract

The present work aimed to explore the protective effects of curcumenol and evaluate its pharmacological mechanisms in 5/6 nephrectomy‐induced chronic renal failure (CRF). Rats with CRF were administrated curcumenol and the effects on renal functions were investigated. Renal function examinations were carried out, whereas serum levels of inflammatory mediators, including NF‐κB, MCP‐1 and IL‐1β were analyzed by ELISA. The mRNA expression levels of SIRT1, p65 and IκBα were measured by qRT‐PCR, and the SIRT1 protein levels were analyzed by western blot and immunohistochemistry. Our results indicated that curcumenol significantly improved the renal functions in the CRF rats. Compared to the sham group, serum levels of NF‐κB, MCP‐1, IL‐1β, and the mRNA expression levels of p65 were significantly increased (p < 0.01), whereas the mRNA expression level of IκBα was significantly decreased (p < 0.01) and the SIRT1 levels were dramatically down‐regulated (p < 0.05) in the CRF groups. Treatment with curcumenol remarkably inhibited inflammatory responses as reflected by the reduced levels of inflammatory mediators (p < 0.01) and SIRT1 up‐regulation (p < 0.05). Our findings suggested that curcumenol could improve the renal function in 5/6 nephrectomy‐induced CRF rats, and the mechanisms might involve suppressing the associated inflammation and modulating the SIRT1 and NF‐κB signaling pathways.

Combined use of Panax notoginseng and leech provides new insights into renal fibrosis: Restoration of mitochondrial kinetic imbalance

“…Previous research has also shown that Ginsenoside Rb1 and Salvianolic Acid D not only protect against renal fibrosis but are also linked to the restoration of mitochondrial function [32][33][34]. Additionally, Dimethylcurcumin and curcumenol have demonstrated efficacy in treating renal disorders [35,36]. Furthermore, chemicals such as 2-hydroxy-3-phenylpropanoic acid and tanshinone I have been proven to be effective antioxidants [37,38].…”

The Extraction, Determination, and Bioactivity of Curcumenol: A Comprehensive Review

“…After increasing the mitochondria mass and function in myotubes, it was reported to promote the initiation of myogenesis and the formation of functional myotubes. Guanghui Zhong found that curcumenol could improve renal function in 5/6 nephrectomy rats with chronic renal failure [162].…”

Traditional Chinese medicine in human diseases treatment: New insights of their potential mechanisms

“…Although this study confirmed the activity of TFA, the related specific molecular mechanisms and signaling pathways need to be further identified. In addition, in another study, Zhong et al (2023) found that curcumenol could improve renal function in 5/6 nephrectomy‐induced chronic renal failure rats via the SIRT1/NF‐κB pathway. To be sure, these studies both emphasized the importance of exploring new therapies for diabetes nephropathy from the TCM perspective.…”