Curcumin, a component of golden spice: From bedside to bench and back

Prasad, Sahdeo; Gupta, Subash C.; Tyagi, Amit; Aggarwal, Bharat B.

doi:10.1016/j.biotechadv.2014.04.004

Cited by 697 publications

(465 citation statements)

References 110 publications

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“…These compounds present in turmeric have long been used in traditional Asian food and medicine. Their therapeutic properties include anticancer, anti-inflammatory, anti-oxidant, anti-Alzeimer's, anti-HIV and anti-Parkinson [1][2][3][4]. Despite their numerous benefits to human health, curcuminoids have poor bioavailability and their natural abundance is low, thus making their heterologous biosynthetic production very interesting.…”

Section: Introductionmentioning

confidence: 99%

“…Caffeoyl-CoA was converted to feruloyl-CoA by CCoAOMT from Medicago sativa. This alternative pathway through caffeic acid allowed, for the first time, the production of curcumin, the most studied curcuminoid for therapeutic purposes and considered in many studies as the most potent and active [3][4], from the amino acid tyrosine, thus representing an advance in the heterologous production of curcumin by E. coli.…”

Section: Introductionmentioning

confidence: 99%

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Production of curcuminoids from tyrosine by a metabolically engineered Escherichia coli using caffeic acid as an intermediate

Rodrigues

Araújo

Prather

et al. 2015

Biotechnology Journal

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Curcuminoids are phenylpropanoids with high pharmaceutical potential. Herein, we report an engineered artificial pathway in Escherichia coli to produce natural curcuminoids through caffeic acid. Arabidopsis thaliana 4-coumaroyl-CoA ligase (4CL1) and Curcuma longa diketide-CoA synthase (DCS) and curcumin synthase (CURS1) were used to produce curcuminoids and 70 mg/L of curcumin was obtained from ferulic acid. Bisdemethoxycurcumin and demethoxycurcumin were also produced, but in lower concentrations, by feeding p-coumaric acid or a mixture of p-coumaric acid and ferulic acid, respectively. Additionally, curcuminoids were produced from tyrosine through the caffeic acid pathway. To produce caffeic acid, tyrosine ammonia lyase (TAL) from Rhodotorula glutinis and 4-coumarate 3-hydroxylase (C3H) from Saccharothrix espanaensis were used. Caffeoyl-CoA 3-O-methyltransferase (CCoAOMT) from Medicago sativa was used to convert caffeoyl-CoA to feruloyl-CoA.Using caffeic acid, p-coumaric acid or tyrosine as a substrate, 3.9 mg/L, 0.3 mg/L and 0.2 mg/L of curcumin were produced, respectively. This is the first time DCS and CURS1 were used in vivo to produce curcuminoids and that curcumin was produced by feeding tyrosine. We have shown that curcumin can be produced using a pathway through caffeic acid. This alternative pathway represents a step forward in the heterologous production of curcumin using E. coli.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Production of curcuminoids from tyrosine by a metabolically engineered Escherichia coli using caffeic acid as an intermediate

Rodrigues

Araújo

Prather

et al. 2015

Biotechnology Journal

View full text Add to dashboard Cite

show abstract

“…This notion could be strongly supported by a large number of related investigations (Chen . 2015a, b;Pan et al 2013;Prasad et al 2014;Sneharani et al 2010), where Cur all exhibited good chemical stability after the NPs fabrication. The chemical stability of Cur at a high temperature (75°C) was also investigated (Fig.…”

Section: The Chemical Stability Of Cur Npsmentioning

confidence: 99%

“…Curcumin (Cur), a natural polyphenol found in the rhizomes of curcuma longa (turmeric), exhibits anti-inflammatory, antineoplastic, antioxidant, and chemopreventive activities (Prasad et al 2014). Several previous clinical trials have addressed the pharmacokinetics, safety, and efficacy of Cur in humans (Dhillon et al 2008).…”

Section: Introductionmentioning

confidence: 99%

Comparison of the colloidal stability, bioaccessibility and antioxidant activity of corn protein hydrolysate and sodium caseinate stabilized curcumin nanoparticles

et al. 2016

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The aims of this work were to construct corn protein hydrolysate (CPH)-based curcumin nanoparticles (Cur NPs) and to compare the colloidal stability, bioaccessibility and antioxidant activity of the Cur NPs stabilized CPH and sodium caseinate (NaCas) respectively. The results indicated that Cur solubility could be considerably improved after the Cur NPs fabrication. The spectroscopy results demonstrated that the solubilization of Cur should be attributed to its complexation with CPH or NaCas. The Cur NPs exhibited good colloidal stability after 1 week's storage but showed smaller (40 nm) size in CPH than in NaCas (100 nm). After lyophilization, the Cur NPs powders showed good rehydration properties and chemical stability, and compared with NaCas, the size of Cur NPs stabilized by CPH was still smaller. Additionally, the Cur NPs exhibited higher chemical stability against the temperature compared with free Cur, and the CPH could protect Cur from degradation more efficiently. Comparing with NaCas, the Cur NPs stabilized by CPH exhibited better bioaccessibility and antioxidant activity. This study demonstrated that CPH may be better than NaCas in Cur NPs fabrication and it opens up the possibility of using hydrophobic protein hydrolysate to construct the NPs delivery system.

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“…It has multiple biological properties including antioxidant, anti‐inflammatory, anti‐infective, anti‐cancer, and wound healing activities [Wilken et al, 2011; Prasad et al, 2014; Rainey et al, 2015]. In regard to its anti‐cancer properties, curcumin can inhibit cell growth and induce apoptosis in a variety of cancer cell lines by modulating the activities of numerous transcription factors, growth regulators, adhesion molecules, apoptotic genes, and cellular signaling pathways [Chen et al, 2014; Wang et al, 2015].…”

Section: Introductionmentioning

confidence: 99%

Synthesis and Cytotoxic Evaluation of Monocarbonyl Analogs of Curcumin as Potential Anti‐Tumor Agents

Pan

Chen

Zhou

et al. 2016

Drug Development Research

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Preclinical Research A series of mono‐carbonyl curcumin analogs with different substituents at the 4/4’‐position of the phenyl group were synthesized and screened for in vitro cytotoxicity against a panel of human cancer cell lines using a methyl thiazolyl tetrazolium assay. Several of the curcumin analogs, especially B114, exhibited a wide‐spectrum of anti‐tumor properties in all tested cell lines, indicating their potential in as anti‐cancer lead compounds. Further toxicity testing in the NRK‐52E kidney cell line revealed that the analogs A111, A113, and B114 had comparable or higher safety than curcumin. These data suggested that the introduction of appropriate substituents in the 4/4’‐positions could be a promising approach for curcumin‐based drug design. Drug Dev Res 77 : 43–49, 2016. © 2016 Wiley Periodicals, Inc.

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Curcumin, a component of golden spice: From bedside to bench and back

Cited by 697 publications

References 110 publications

Production of curcuminoids from tyrosine by a metabolically engineered Escherichia coli using caffeic acid as an intermediate

Production of curcuminoids from tyrosine by a metabolically engineered Escherichia coli using caffeic acid as an intermediate

Comparison of the colloidal stability, bioaccessibility and antioxidant activity of corn protein hydrolysate and sodium caseinate stabilized curcumin nanoparticles

Synthesis and Cytotoxic Evaluation of Monocarbonyl Analogs of Curcumin as Potential Anti‐Tumor Agents

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