Curcumin - A promising nutritional strategy for chronic kidney disease patients

Alvarenga, Livia; Leal, Viviane de Oliveira; Borges, Natália Alvarenga; Aguiar, Aline Silva de; Faxén‐Irving, Gerd; Stenvinkel, Peter; Lindholm, Bengt; Mafra, Denise

doi:10.1016/j.jff.2017.12.015

Cited by 61 publications

(42 citation statements)

References 60 publications

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“…It follows diverse pathways to inhibit the inflammation. Abbreviation: Nuclear factor erythroid-derived 2(Nrf2), Kelch-like ECH-associated protein 1, antioxidant responsive element (ARE), glutathione S-transferase (GST), glutathione peroxidase (GSH), superoxide dismutase (SOD), peroxisome proliferator-acitvated receptor-γ (PPAR-γ), PPAR responsive elements (PPRE), nuclear factor-κB (NFκB), inhibitor of kinases (IκB Adapted with permission from ref ( 179 ).…”

Section: Nanotheranostics Perspectivementioning

confidence: 99%

Comprehensive Review on Current Interventions, Diagnostics, and Nanotechnology Perspectives against SARS-CoV-2

et al. 2020

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The coronavirus disease 2019 (COVID-19) has dramatically challenged the healthcare system of almost all countries. The authorities are struggling to minimize the mortality along with ameliorating the economic downturn. Unfortunately, until now, there has been no promising medicine or vaccine available. Herein, we deliver perspectives of nanotechnology for increasing the specificity and sensitivity of current interventional platforms toward the urgent need of quickly deployable solutions. This review summarizes the recent involvement of nanotechnology from the development of a biosensor to fabrication of a multifunctional nanohybrid system for respiratory and deadly viruses, along with the recent interventions and current understanding about severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).

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Section: Nanotheranostics Perspectivementioning

confidence: 99%

Comprehensive Review on Current Interventions, Diagnostics, and Nanotechnology Perspectives against SARS-CoV-2

et al. 2020

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“…Importantly, hemodynamic alterations such as oxidative stress, hyperfiltration and glomerular hypertension were reduced by curcumin via increased antioxidant activity and decreased MDA 93 . Curcumin can be beneficial in uremia problem and treatment of intestinal dysbiosis, and can improve renal functions and defend the kidney against renal failure by decreasing the expression of mRNA of inflammatory proteins (monocyte chemoattractant protein-1) and down-regulating matrix proteins, collagen, TGF-B, and laminin 94 .…”

Section: Renal Systemmentioning

confidence: 99%

Therapeutic potential of curcumin against lead-induced toxicity: A review

et al. 2019

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Lead poisoning causes numerous clinical implications in almost all organs, with the brain, liver, and kidneys serving as the primary targets due to the abundant presence of mitochondria. Curcumin is one of the most potent constituents of Curcuma longa, which is lipophilic, phenolic and water insoluble. Curcumin is a strong antioxidant and anti-inflammatory agent in the treatments of neurodegenerative disease, cardiovascular, renal, and liver diseases, with a potential anticancer mechanism in a few clinical and experimental trials. This review will focus on the health impact of lead-induced toxicity in different organ-systems, which occurs as result of increased oxidative stress through the generation of reactive oxygen species (ROS) and reactive nitrogen species (RNS) and will discuss the therapeutic potential of curcumin against lead-induced toxicity in both human and animals.

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“…Furthermore, the therapeutic effects of curcumin and curcumin derivatives have been proven in numerous diseases such as endometriosis, 9 Crohn's disease, 10 pulmonary diseases, 11 cardiac diseases, 12 and kidney diseases. 13 In recent years, as a milestone in the history of therapeutic effects of this golden drug, curcumin has gained much attention in the field of cancer Abbreviation: AFM, Atomic force microscopy; BCL2, BCL2, apoptosis regulator; BAX, Bcl-2associated X; CASP3, Caspase 3; CASP8, Caspase 8; CASP9, Caspase 9; CPNs, Curcuminencapsulated polymersome nanoparticles; CSC, Cancer stem cell; CRC, Colorectal cancer; DL, Drug loading; DLS, Dynamic light scattering; EE, Encapsulation efficiency; PEG, Polyethylene glycol; PEG400-OA, Polyethylene glycol 400-oleate; p53, Tumor protein p53; SEM, Scanning electron microscopy; TEM, Transmission electron microscopy research 14 because of its activities against numerous cancer cells with various origins such as skin, prostate, ovary, colon, breast, brain, blood, liver, and pancreas. This function is fulfilled through communication with several cell signaling pathways, 15 triggering apoptosis and cell cycle inhibition, 16 as well as intervention with some characteristics of cancerous cells such as uncontrolled cell proliferation, invasion, metastasis, and angiogenesis.…”

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confidence: 99%

Polymersome‐assisted delivery of curcumin: A suitable approach to decrease cancer stemness markers and regulate miRNAs expression in HT29 colorectal cancer cells

Pakizehkar

Ranji

Sohi

et al. 2019

Polymers for Advanced Techs

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Curcumin as a safe traditional compound has various benefits such as anticancer activities. However, low solubility in water is a problem. Herein, curcumin encapsulated in polymersome nanoparticles (CPNs) have been developed, the physicochemical properties have been evaluated, and cytotoxicity effects on HT29 cells were evaluated by MTT assay and annexin V/PI staining. The expression of stemness markers including CD44, CD133, and CD24, as well as miRNAs (miR‐126, miR‐34a, miR‐21, miR‐155, miR‐221, and miR‐222) and some potential targets, was evaluated in CPNs‐treated and untreated cells. Physicochemical analysis confirmed the encapsulation of curcumin in polymersomes and showed a spherical shape, an appropriate mean size of 259.5±1.5 nm, the acceptable polydispersity index of ~ 0.465, and the zeta potential of (‐8.74±0.2), as well as long‐term storage of CPNs at 4°C. According to the result, CPNs with the IC50 of 14 μg/ml increased apoptosis and induced S arrest in treated cells. Flow cytometry analysis showed the decrease in cancer stemness markers. RT‐qPCR analysis identified the downregulation of miR‐21, miR‐155, and miR‐221/222, as well as upregulation of miR‐34a, miR‐126, and deregulation of some apoptotic targets such as P53, CASP9, CASP8, CASP3, BAX, and BCl‐2 in CPNs‐treated cells. As a result, CPNs can be a safe and effective complementary agent to diminish cancer stem cells and tumor recurrence in colorectal cancer therapy.

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Curcumin - A promising nutritional strategy for chronic kidney disease patients

Cited by 61 publications

References 60 publications

Comprehensive Review on Current Interventions, Diagnostics, and Nanotechnology Perspectives against SARS-CoV-2

Comprehensive Review on Current Interventions, Diagnostics, and Nanotechnology Perspectives against SARS-CoV-2

Therapeutic potential of curcumin against lead-induced toxicity: A review

Polymersome‐assisted delivery of curcumin: A suitable approach to decrease cancer stemness markers and regulate miRNAs expression in HT29 colorectal cancer cells

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