Curcumin activation of nuclear factor E2-related factor 2 gene (Nrf2): Prophylactic and therapeutic effect in nonalcoholic steatohepatitis (NASH)

El-Hameed, Nahla Mohammed Abd; El-Aleem, Seham A Abd; Khattab, Mahmoud A.; Ali, Azza Hussein; Mohammed, Hanaa Hassanein

doi:10.1016/j.lfs.2021.119983

Cited by 15 publications

(9 citation statements)

References 86 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It also inhibits HMGB1-NF-κB translocation, macrophage M1 polarization, and inflammatory factor secretion to reduce liver damage. Cur can alleviate NASH by upregulating the Nrf2 gene, protecting mitochondria, and reducing apoptosis. , Additionally, Cur improves hepatic lipid accumulation to curb NASH development through the AMPK-mTOR signaling pathway . THC is reported to protect against NAFLD by reducing adipogenesis, activating AMP-activated protein kinase, and increasing fatty acid oxidation .…”

Section: Discussionmentioning

confidence: 99%

Curcumin Alleviates High-fat Diet-induced Nonalcoholic Steatohepatitis via Improving Hepatic Endothelial Function with Microbial Biotransformation in Rats

Huang

et al. 2023

J. Agric. Food Chem.

View full text Add to dashboard Cite

Hepatic endothelial function is central to the development of nonalcoholic steatohepatitis (NASH). Curcumin (Cur) is reportedly hepatoprotective, however, it remains unknown whether Cur improves hepatic endothelial function in NASH. Additionally, the poor bioavailability of Cur renders it difficult to elucidate its hepatoprotective effect, hence, its biotransformation should be considered. Herein, we investigated the effects and mechanisms of Cur and its bioconversion on hepatic endothelial function against high-fat diet-induced NASH in rats. The results revealed that Cur improved hepatic lipid accumulation, inflammation, and endothelial dysfunction by inhibiting NF-κB and PI3K/Akt/HIF-1α pathways, however, these effects were weakened via antibiotic addition, which was closely related to reduced tetrahydrocurcumin (THC) produce in the liver and intestinal content. Moreover, THC exerted a better effect than Cur on restoring liver sinusoidal endothelial cells function to attenuate steatosis and injury in L02 cells. Thus, these findings indicate that the effect of Cur on NASH is closely related to hepatic endothelial function improvement with intestinal microbial biotransformation.

show abstract

Section: Discussionmentioning

confidence: 99%

Curcumin Alleviates High-fat Diet-induced Nonalcoholic Steatohepatitis via Improving Hepatic Endothelial Function with Microbial Biotransformation in Rats

Huang

et al. 2023

J. Agric. Food Chem.

View full text Add to dashboard Cite

show abstract

“…One of the drugs was curcumin, which is herbal polyphenolic compound, could be a doable therapy alternative for patients with COVID‐19 through inhibiting the entry of virus to the cell, inhibiting encapsulation of the virus and viral protease and modulating a variety of cellular signaling pathways 61 . Curcumin was also found to be a possible novel treatment for nonalcoholic steatohepatitis (NASH) by mitochondria protection and apoptosis reduction, which could be the therapeutic target for AH through the same way 62 . Other drugs like progesterone, which has been observed to have immunomodulatory and anti‐inflammatory effects by enhancing immune tolerance and antibody production.…”

Section: Discussionmentioning

confidence: 99%

“…61 Curcumin was also found to be a possible novel treatment for nonalcoholic steatohepatitis (NASH) by mitochondria protection and apoptosis reduction, which could be the therapeutic target for AH through the same way. 62 Other drugs like progesterone, which has been observed to have immunomodulatory and anti-inflammatory effects by enhancing immune tolerance and antibody production. It can be used in combination with high physiological concentrations of the steroids 17β-estradiol to improve immune dysregulation caused by the COVID-19 cytokine storm.…”

Section: Discussionmentioning

confidence: 99%

Exploration of the link between COVID‐19 and alcoholic hepatitis from the perspective of bioinformatics and systems biology

Huang

Zhou

et al. 2023

MedComm – Future Medicine

View full text Add to dashboard Cite

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been suggested to purpose threats to health of mankind. Alcoholic hepatitis (AH) is a life-threatening acute and chronic liver failure that takes place in sufferers who drink excessively. During the epidemic, AH has an increasing incidence of severe illness and mortality. The intrinsic relationship of molecular pathogenesis, as well as common therapeutic strategies for two diseases are still poorly understood. The transcriptome of the COVID-19 and AH has been compared to obtain the altered genes and hub genes were screened out through protein-protein interaction (PPI) network analysis.Via gene ontology (GO), pathway enrichment, and transcription regulator analysis, a deeper appreciation of the interplay mechanism between hub genes were established. Finally, gene-disease and gene-drug analysis were displayed to instruct the clinical treatments. With 181 common differentially expressed genes (DEGs) of AH and COVID-19 were obtained, 10 hub genes were captured. Follow-up studies located that these 10 genes typically mediated the diseases occurrence by regulating the activities of the immune system. Other results suggest that the common pathways of the two ailments are enriched in regulating the function of immune cells and release of immune molecules. The top 10 drug candidates have been chosen primarily, some of which have been proved effective in treating AH sufferers infected with COVID-19. This study reveals the common pathogenesis of COVID-19 and AH and assist to discover necessary therapeutic targets to combat the ongoing pandemic induced via MedComm -Future Medicine.

show abstract

“…Oxidative stress caused by drugs, viruses, alcohol, and other factors is the main cause of liver damage, which can further aggravate drug-induced liver damage, fatty liver, viral hepatitis, autoimmune liver disease, liver fibrosis, and primary liver cancer. The Nrf2 pathway is widely involved in many aspects of the body’s defense against oxidative stress, such as detoxification, anti-inflammatory processes, and the regulation of cellular metabolism [ 152 , 153 , 154 , 155 , 156 ].…”

Section: Research Progress Of Nrf2 In Inflammation-related Diseasesmentioning

confidence: 99%

Clinical Research Progress of Small Molecule Compounds Targeting Nrf2 for Treating Inflammation-Related Diseases

et al. 2022

View full text Add to dashboard Cite

Studies have found that inflammation is a symptom of various diseases, such as coronavirus disease 2019 (COVID-19) and rheumatoid arthritis (RA); it is also the source of other diseases, such as Alzheimer’s disease (AD), Parkinson’s disease (PD), lupus erythematosus (LE), and liver damage. Nrf2 (nuclear factor erythroid 2-related factor 2) is an important multifunctional transcription factor in cells and plays a central regulatory role in cellular defense mechanisms. In recent years, several studies have found a strong association between the activation of Nrf2 and the fight against inflammation-related diseases. A number of small molecule compounds targeting Nrf2 have entered clinical research. This article reviews the research status of small molecule compounds that are in clinical trials for the treatment of COVID-19, rheumatoid arthritis, Alzheimer’s disease, Parkinson’s disease, lupus erythematosus, and liver injury.

show abstract

Curcumin activation of nuclear factor E2-related factor 2 gene (Nrf2): Prophylactic and therapeutic effect in nonalcoholic steatohepatitis (NASH)

Cited by 15 publications

References 86 publications

Curcumin Alleviates High-fat Diet-induced Nonalcoholic Steatohepatitis via Improving Hepatic Endothelial Function with Microbial Biotransformation in Rats

Curcumin Alleviates High-fat Diet-induced Nonalcoholic Steatohepatitis via Improving Hepatic Endothelial Function with Microbial Biotransformation in Rats

Exploration of the link between COVID‐19 and alcoholic hepatitis from the perspective of bioinformatics and systems biology

Clinical Research Progress of Small Molecule Compounds Targeting Nrf2 for Treating Inflammation-Related Diseases

Contact Info

Product

Resources

About