Curcumin alleviates Alzheimer’s disease by inhibiting inflammatory response, oxidative stress and activating the AMPK pathway

Neuroprotective and anti‐inflammatory effects of curcumin in Alzheimer's disease: Targeting neuroinflammation strategies

“…Curcumin demonstrated neuroprotective effects in AD models, partially by modulating the AMPK/SIRT1 pathway; the activation of AMPK and SIRT1 by curcumin results in improved mitochondrial function, decreased oxidative stress, and reduced neuroinflammation, supporting its potential as a therapeutic agent in AD(Sadek et al, 2023). Curcumin's activation of AMPK has been shown to promote autophagy, a critical process for the removal of damaged cellular components and misfolded proteins, including amyloid-beta and hyperphosphorylated Tau in AD; by stimulating autophagy, curcumin aids in reducing the toxic protein aggregates that contribute to AD pathology(Mishra et al, 2022;Shao et al, 2023). SIRT1 activation by curcumin enhances DNA repair processes, increases the expression of antioxidant enzymes, and promotes neuronal survival by deacetylating key transcription factors and proteins involved in stress resistance and cell survival pathways(Ungurianu et al, 2022;Zendedel et al, 2018).…”

“…AMPK/SIRT1 signaling modulation " AMPK, "SIRT1, " mitochondrial function, # Oxidative stress, # neuroinflammation. " Autophagy, "mitochondrial biogenesis, " Insulin sensitivity and glucose metabolism in brain cellsRazick et al, 2023;Sadek et al, 2023;Mishra et al, 2022;Shao et al, 2023;Ungurianu et al, 2022;Zendedel et al, 2018;Chen, Ruan, et al, 2023;Deng et al, 2023;Hao et al, 2023;Das et al, 2019;Assefa et al, 2020 Epigenetic modulation " DNMTs, "HDACs " Acetylation of histones " Impact on miRNA expression to regulate gene " expression related to neuroprotection and inflammation F. U Hassan et al, 2019;Castillo-Ordoñez et al, 2024;Howell et al, 2013;Abuelezz et al, 2021. Note: Symbols: ", enhancing/increasing effect.…”