Curcumin alleviates LPS-induced intestinal homeostatic imbalance through reshaping gut microbiota structure and regulating group 3 innate lymphoid cells in chickens

Ruan, D.; Wu, Shaowen; Fouad, Ahmed M.; Zhu, Yongwen; Huang, Wenjie; Chen, Zhilong; Gou, Zhongyong; Wang, Yibing; Han, Yongquan; Zheng, Chuntian; Jiang, Sufei

doi:10.1039/d2fo02598a

Cited by 15 publications

(6 citation statements)

References 55 publications

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“…In turn, the TCA cycle can also influence amino acid and lipid metabolism through the synthesis of metabolites. Ruan, et al (2022) reported that LPS attack resulted in an imbalance in broiler intestinal homeostasis with changes in the levels of metabolites related to energy metabolism, including reduced concentrations of butyric acid, 3-hydroxybutyric acid, malic acid, and succinic acid, and increased levels of alanine. Zhao et al (2022) found that LPS produced 3 breakpoints in the TCA cycle of macrophages, namely, downregulation of isocitrate dehydrogenase, inhibition of succinate accumulation and SDH activity, and a significant decrease in the expression level of carboglutarate dehydrogenase and its substrate α-ketoglutarate.…”

Section: Discussionmentioning

confidence: 99%

Molecular and metabolic responses to immune stress in the jejunum of broiler chickens: transcriptomic and metabolomic analysis

Hu,

Du,

Shao

et al. 2024

Poultry Science

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Section: Discussionmentioning

confidence: 99%

Molecular and metabolic responses to immune stress in the jejunum of broiler chickens: transcriptomic and metabolomic analysis

Hu,

Du,

Shao

et al. 2024

Poultry Science

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“…It was reported that 250 mg/kg CUR supplementation increased body weight, ADG and ADFI in genotype AA commercial broilers at 21 and 42 days of age, and significantly reduced FCR [ 20 ]. The CUR supplementation at 300 mg/kg increased ADG during days 1–21, regardless of LPS stimulation [ 21 ]. In our study, CUR supplementation had no significant effect on growth performance, and neither PE nor CUR addition had a significant effect on ADFI and FCR.…”

Section: Discussionmentioning

confidence: 99%

Effects of Pueraria Extract and Curcumin on Growth Performance, Antioxidant Status and Intestinal Integrity of Broiler Chickens

Guo

et al. 2023

Animals

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The current study was carried out to examine the effects of pueraria extract (PE) and curcumin (CUR) on growth performance, antioxidant capacity and intestinal integrity in broiler chickens. A complete randomized design with a 2 × 2 factorial arrangement of treatments was employed to assign 200 one-day-old Ross-308 broilers to four groups, each including five replicates of ten birds. Chickens in the control group (CON) were fed the basal diet, while the PE, CUR and PE+CUR groups were supplemented with 200 mg/kg PE or 200 mg/kg CUR or 200 mg/kg PE+ 200 mg/kg CUR. This trial lasted for 28 days. The PE supplementation decreased the average daily gain during the whole period (p < 0.05). The PE+CUR group had a higher feed conversion ratio than that of the PE and CUR groups during days 14–28 and 1–28 (p < 0.05). Dietary CUR supplementation increased duodenal T-SOD activity (p < 0.05). Compared with the CON group, the other three groups increased the duodenal GSH-Px activity, the PE+CUR group reduced the duodenal H2O2 level, and the CUR and PE groups elevated the ileal GSH-Px activity and the ratio of jejunal villus height to crypt depth, respectively (p < 0.05). The addition of PE decreased crypt depth and increased villus area and mucin-2 mRNA level in the jejunum (p < 0.05). Overall, dietary supplementation with PE, CUR, or a combination of these, enhanced the antioxidant status and intestinal integrity of broilers.

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“…In contrast, lithocholic acid (LCA) ameliorated the TNF-α-induced distribution of ZO-1, E-cadherin, occludin, and claudin-1 [15]. The administration of curcumin, a polyphenolic compound isolated from turmeric, decreased the lipopolysaccharides (LPS)-induced injury of intestinal tight junctions and alleviated acute inflammation in the mucosa, likely through altering the microbiome and modulation of bile acid metabolism [16]. .…”

Section: Bile Acids and Intestinal Epithelial Cells Tight Junctionsmentioning

confidence: 99%

Bile Acids, Intestinal Barrier Dysfunction, and Related Diseases

Shi

Jin

Huang

2023

Cells

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The intestinal barrier is a precisely regulated semi-permeable physiological structure that absorbs nutrients and protects the internal environment from infiltration of pathological molecules and microorganisms. Bile acids are small molecules synthesized from cholesterol in the liver, secreted into the duodenum, and transformed to secondary or tertiary bile acids by the gut microbiota. Bile acids interact with bile acid receptors (BARs) or gut microbiota, which plays a key role in maintaining the homeostasis of the intestinal barrier. In this review, we summarize and discuss the recent studies on bile acid disorder associated with intestinal barrier dysfunction and related diseases. We focus on the roles of bile acids, BARs, and gut microbiota in triggering intestinal barrier dysfunction. Insights for the future prevention and treatment of intestinal barrier dysfunction and related diseases are provided.

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Curcumin alleviates LPS-induced intestinal homeostatic imbalance through reshaping gut microbiota structure and regulating group 3 innate lymphoid cells in chickens

Abstract: Curcumin could be used as a modulator of gut microbiota for intestinal health improvement and immunity homeostasis via modulation of the BA-FXR pathway and ILC3s function.

Cited by 15 publications

References 55 publications

Molecular and metabolic responses to immune stress in the jejunum of broiler chickens: transcriptomic and metabolomic analysis

Molecular and metabolic responses to immune stress in the jejunum of broiler chickens: transcriptomic and metabolomic analysis

Effects of Pueraria Extract and Curcumin on Growth Performance, Antioxidant Status and Intestinal Integrity of Broiler Chickens

Bile Acids, Intestinal Barrier Dysfunction, and Related Diseases

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