Curcumin ameliorates ethanol-induced memory deficits and enhanced brain nitric oxide synthase activity in mice

Yu, Shu; Gao, Rui; Zhang, Lin; Luo, Junxia; Jiang, Hong; Wang, Shuanglian

doi:10.1016/j.pnpbp.2013.03.001

Cited by 29 publications

(21 citation statements)

References 41 publications

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“…Curcumin has been recognized as an effective agent for neurodegenerative diseases, because of its neuroprotective effects in PD, AD, and ALS [45]. Curcumin also ameliorates neurotoxicity induced by various toxicants such as metals (fluoride, lead, and arsenic), solvents, 6-OHDA, and Aβ [36,37,[40][41][42][43][44]. Recently, we found that curcumin enhanced the adult hippocampal neurogenesis as well as improved learning and memory deficits in AD model via recruitment of the Wnt/β-catenin pathway [41].…”

Section: Discussionmentioning

confidence: 99%

“…Curcumin attenuates neurotoxicity induced by various toxicants such as fluoride, acrolein, okadaic acid, lead, ethanol, arsenic, sodium metabisulfite, 6-hydroxydopamine (6-OHDA), and amyloid-β (Aβ) [34][35][36][37][38][39][40][41][42][43][44]. Curcumin also provides neuroprotection in cellular and animal models of neurological and neurodegenerative disorders including Parkinson's disease (PD), Alzheimer's disease (AD), Huntington's disease (HD), depression, multiple sclerosis, and schizophrenia [45][46][47][48].…”

Section: Introductionmentioning

confidence: 99%

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Bisphenol-A Mediated Inhibition of Hippocampal Neurogenesis Attenuated by Curcumin via Canonical Wnt Pathway

et al. 2015

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Bisphenol A (BPA) is an environmental xenoestrogenic endocrine disruptor, utilized for production of consumer products, and exerts adverse effects on the developing nervous system. Recently, we found that BPA impairs the finely tuned dynamic processes of neurogenesis (generation of new neurons) in the hippocampus of the developing rat brain. Curcumin is a natural polyphenolic compound, which provides neuroprotection against various environmental neurotoxicants and in the cellular and animal models of neurodegenerative disorders. Here, we have assessed the neuroprotective efficacy of curcumin against BPA-mediated reduced neurogenesis and the underlying cellular and molecular mechanism(s). Both in vitro and in vivo studies showed that curcumin protects against BPA-induced hippocampal neurotoxicity. Curcumin protects against BPA-mediated reduced neural stem cells (NSC) proliferation and neuronal differentiation and enhanced neurodegeneration. Curcumin also enhances the expression/levels of neurogenic and the Wnt pathway genes/proteins, which were reduced due to BPA exposure in the hippocampus. Curcumin-mediated neuroprotection against BPA-induced neurotoxicity involved activation of the Wnt/β-catenin signaling pathway, which was confirmed by the use of Wnt specific activators (LiCl and GSK-3β siRNA) and inhibitor (Dkk-1). BPA-mediated increased β-catenin phosphorylation, decreased GSK-3β levels, and β-catenin nuclear translocation were significantly reversed by curcumin, leading to enhanced neurogenesis. Curcumin-induced protective effects on neurogenesis were blocked by Dkk-1 in NSC culture treated with BPA. Curcumin-mediated enhanced neurogenesis was correlated well with improved learning and memory in BPA-treated rats. Overall, our results conclude that curcumin provides neuroprotection against BPA-mediated impaired neurogenesis via activation of the Wnt/β-catenin signaling pathway.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Bisphenol-A Mediated Inhibition of Hippocampal Neurogenesis Attenuated by Curcumin via Canonical Wnt Pathway

et al. 2015

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“…50 Curcumin shows neuroprotective effects against ethanol-, aluminum-, and iron-induced neurotoxicity in rodents. 51,52 In the okadaic acid-induced impairment model, oral administration of curcumin significantly improves the memory function as assessed by both Morris water maze and passive avoidance tests. 53 Under normal aging and increased oxidative stress conditions, memory function declines due to decreases in BDNF.…”

Section: Discussionmentioning

confidence: 99%

Effects of Curcumin (Curcuma longa) on Learning and Spatial Memory as Well as Cell Proliferation and Neuroblast Differentiation in Adult and Aged Mice by Upregulating Brain-Derived Neurotrophic Factor and CREB Signaling

Nam

Choi

Yoo

et al. 2014

Journal of Medicinal Food

106

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Aging is a progressive process, and it may lead to the initiation of neurological diseases. In this study, we investigated the effects of wild Indian Curcuma longa using a Morris water maze paradigm on learning and spatial memory in adult and D-galactose-induced aged mice. In addition, the effects on cell proliferation and neuroblast differentiation were assessed by immunohistochemistry for Ki67 and doublecortin (DCX) respectively. The aging model in mice was induced through the subcutaneous administration of D-galactose (100 mg/kg) for 10 weeks. C. longa (300 mg/kg) or its vehicle (physiological saline) was administered orally to adult and D-galactose-treated mice for the last three weeks before sacrifice. The administration of C. longa significantly shortened the escape latency in both adult and D-galactose-induced aged mice and significantly ameliorated D-galactose-induced reduction of cell proliferation and neuroblast differentiation in the subgranular zone of hippocampal dentate gyrus. In addition, the administration of C. longa significantly increased the levels of phosphorylated CREB and brain-derived neurotrophic factor in the subgranular zone of dentate gyrus. These results indicate that C. longa mitigates D-galactose-induced cognitive impairment, associated with decreased cell proliferation and neuroblast differentiation, by activating CREB signaling in the hippocampal dentate gyrus.

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“…K. Kulkarni et al, 2008). Several studies have reported the neuroprotective potential of curcumin in prevention of the learning and memory impairments that arise from phenytoin (Reeta et al, 2009), homocysteine (Ataie et al, 2010), cigarette smoke (Jaques et al, 2012), ethanol (Yu et al, 2013), amyloid-β (Yin et al, 2014), and okadaic acid (Rajasekar et al, 2013). Also dietary supplementation with curcumin is favorable in neurodegenerative disorders such as Alzheimer's disease (Calabrese et al, 2003;Yang et al, 2005).…”

Section: Introductionmentioning

confidence: 99%

Curcumin alleviates cisplatin-induced learning and memory impairments

Öz

Atalık

Yerlikaya

et al. 2015

Neurobiology of Learning and Memory

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Curcumin ameliorates ethanol-induced memory deficits and enhanced brain nitric oxide synthase activity in mice

Cited by 29 publications

References 41 publications

Bisphenol-A Mediated Inhibition of Hippocampal Neurogenesis Attenuated by Curcumin via Canonical Wnt Pathway

Bisphenol-A Mediated Inhibition of Hippocampal Neurogenesis Attenuated by Curcumin via Canonical Wnt Pathway

Effects of Curcumin (Curcuma longa) on Learning and Spatial Memory as Well as Cell Proliferation and Neuroblast Differentiation in Adult and Aged Mice by Upregulating Brain-Derived Neurotrophic Factor and CREB Signaling

Curcumin alleviates cisplatin-induced learning and memory impairments

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