Curcumin ameliorates focal segmental glomerulosclerosis by inhibiting apoptosis and oxidative stress in podocytes

Zhang, Hui; Dong, Qing-Qing; Shu, Hua-Pan; Tu, Yu-Chi; Liao, Qian-Qian; Yao, Li-Jun

doi:10.1016/j.abb.2023.109728

Archives of Biochemistry and Biophysics

2023

DOI: 10.1016/j.abb.2023.109728

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Curcumin ameliorates focal segmental glomerulosclerosis by inhibiting apoptosis and oxidative stress in podocytes

Hui Zhang,

Qing-Qing Dong,

Hua-Pan Shu

et al.

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Cited by 3 publications

References 57 publications

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Molecular signaling pathways in doxorubicin-induced nephrotoxicity and potential therapeutic agents

Lu,

Wei,

Gao

et al. 2025

International Immunopharmacology

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Molecular signaling pathways in doxorubicin-induced nephrotoxicity and potential therapeutic agents

Lu,

Wei,

Gao

et al. 2025

International Immunopharmacology

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Analyzing the potential targets and mechanisms of chronic kidney disease induced by common synthetic Endocrine Disrupting Compounds (EDCs) in Chinese surface water environment using network toxicology and molecular docking techniques

Pei,

Peng,

et al. 2025

Science of The Total Environment

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Renal Health Through Medicine–Food Homology: A Comprehensive Review of Botanical Micronutrients and Their Mechanisms

Zhao,

Song,

Feng

et al. 2024

Nutrients

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Background: As an ancient concept and practice, “food as medicine” or “medicine–food homology” is receiving more and more attention these days. It is a tradition in many regions to intake medicinal herbal food for potential health benefits to various organs and systems including the kidney. Kidney diseases usually lack targeted therapy and face irreversible loss of function, leading to dialysis dependence. As the most important organ for endogenous metabolite and exogenous nutrient excretion, the status of the kidney could be closely related to daily diet. Therefore, medicinal herbal food rich in antioxidative, anti-inflammation micronutrients are ideal supplements for kidney protection. Recent studies have also discovered its impact on the “gut–kidney” axis. Methods: Here, we review and highlight the kidney-protective effects of botanicals with medicine–food homology including the most frequently used Astragalus membranaceus and Angelica sinensis (Oliv.) Diels, concerning their micronutrients and mechanism, offering a basis and perspective for utilizing and exploring the key substances in medicinal herbal food to protect the kidney. Results: The index for medicine–food homology in China contains mostly botanicals while many of them are also consumed by people in other regions. Micronutrients including flavonoids, polysaccharides and others present powerful activities towards renal diseases. Conclusions: Botanicals with medicine–food homology are widely speeded over multiple regions and incorporating these natural compounds into dietary habits or as supplements shows promising future for renal health.

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Curcumin ameliorates focal segmental glomerulosclerosis by inhibiting apoptosis and oxidative stress in podocytes

Cited by 3 publications

References 57 publications

Molecular signaling pathways in doxorubicin-induced nephrotoxicity and potential therapeutic agents

Molecular signaling pathways in doxorubicin-induced nephrotoxicity and potential therapeutic agents

Analyzing the potential targets and mechanisms of chronic kidney disease induced by common synthetic Endocrine Disrupting Compounds (EDCs) in Chinese surface water environment using network toxicology and molecular docking techniques

Renal Health Through Medicine–Food Homology: A Comprehensive Review of Botanical Micronutrients and Their Mechanisms

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