Curcumin analogue 1,5-bis(4-hydroxy-3-((4-methylpiperazin-1-yl)methyl)phenyl)penta-1,4-dien-3-one mediates growth arrest and apoptosis by targeting the PI3K/AKT/mTOR and PKC-theta signaling pathways in human breast carcinoma cells

Curcumin Ameliorates Chronic Renal Failure in 5/6 Nephrectomized Rats by Regulation of the mTOR/HIF-1α/VEGF Signaling Pathway

“…Phosphorylated mTOR phosphorylates Thr70 of 4E-BP1, thereby disrupting the integrity of the eIF-4E/4E-BP1 complex, which is essential for inhibition of capdependent mRNA translation, resulting in enhanced HIF-1α protein translation. 12,13,34) Moreover, phosphorylated mTOR also phosphorylates Thr389 of P70S6K, which promotes the phosphorylation of its substrate, ribosomal protein S6, and induces HIF-1α protein translation. 34) In the present study, the expression levels of mTOR, p-mTOR (at serine 2448), P70S6K1, p-P70S6K1 (at threonine 389), 4E-BP1, p-4E-BP1 (at threonine 70), and HIF-1α were increased in the kidneys of 5/6 nephrectomized rats, which could promote the expression of VEGF, thereby implicating the mTOR/HIF-1α/VEGF pathway in the development of CRF.…”

“…These results suggest that the protective effect of curcumin on CRF is dependent on the suppression of the mTOR/HIF-1α/VEGF pathway. Curcumin is the active ingredient of the traditional herbal remedy and dietary spice turmeric (Curcuma longa), which has been shown to suppress activation of the PI3K/Akt/ mTOR signaling pathway in cancers of the breast, 35) lung, 36) bladder, 37) and colon. 38) Additionally, as a potential treatment for renal diseases, curcumin was found to effectively promote the proliferation of renal tubular epithelial cells and possess a remarkable ability to block tubular EMT and maintain the morphology and phenotype of renal tubule epithelium cells via inhibition of the Akt/mTOR pathway.…”

A multivariate statistical analysis of the effects of styrene maleic acid encapsulated RL71 in a xenograft model of triple negative breast cancer

“…In the present study, PKC-α was decreased by 78% following SMA-RL71 treatment in vivo. Similarly, the curcumin analogue, J1, inhibited the phosphorylation of PKC-theta in MDA-MB-231 and MCF7 cells by approximately 89% and 91%, respectively after 12 h [42]. Studies have also shown that the presence of heat shock protein 105 recruits PP2A, which in turn prevents the phosphorylation of the β-catenin degradation complex and subsequently activates Wnt-signaling that leads to cell proliferation and inhibition of apoptosis [43,44].…”

“…In a study by Dieninger et al [46], 28 statistically significant m/z species were differentially expressed from 15 metastasized and 17 non-metastasized Barrett's adenoma cases. Hierarchical clustering was performed on 10 of the most significant m/z species of the tumor tissues, which distinguished Barrett's adenocarcinoma with lymph node metastasis from those without lymph node metastasis with 81% accuracy, following a specificity and sensitivity of 77% and 94%, respectively [42]. Also, hierarchical clustering of mass spectra of proteins identified by matrix-assisted laser desorption ionization imaging correctly separated gastric cancer and non-neoplastic mucosa [42].…”

“…Hierarchical clustering was performed on 10 of the most significant m/z species of the tumor tissues, which distinguished Barrett's adenocarcinoma with lymph node metastasis from those without lymph node metastasis with 81% accuracy, following a specificity and sensitivity of 77% and 94%, respectively [42]. Also, hierarchical clustering of mass spectra of proteins identified by matrix-assisted laser desorption ionization imaging correctly separated gastric cancer and non-neoplastic mucosa [42]. CA in our studies showed that pEGFR clustered closely with tumor volume, which is consistent with the results of the LDA and RFC analyses.…”