Curcumin analogue C66 attenuates obesity-induced renal injury by inhibiting chronic inflammation

Lin, Yuanyuan; Hu, Xueting; Hu, Xiang; Yin, Sihui; Chen, Jianqiang; He, Huang; Hong, Shanshan; Yang, Bin; Singh, Krishna K.; Feng, Jiaxuan; Wang, Yi; Luo, Wei; Liang, Guang

doi:10.1016/j.biopha.2021.111418

Cited by 20 publications

(17 citation statements)

References 43 publications

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“…In addition, the renal corpuscles appeared with almost normal shape as it was formed of a central tuft of capillaries surrounded by Bowman's capsules. These observations are in a harmony with Ye et al (2021) who demonstrated that visible pathological changes which showed significantly higher amorphous pink eosin staining in the Bowman's capsules indicating increased hyalinization and higher hematoxylin blue staining indicating pronounced infiltration of lymphocytes in the HFD-fed in comparison to the LFD-fed mice, which was significantly reduced in curcumin-treated HFD-fed mice.…”

Section: 2-histopathological Findingssupporting

confidence: 88%

Therapeutic Effects of Curcumin against Obesity and Obesity Induced Renal Pathology in Experimental Animal Models

El-Kader

Awadalla

Abdelsadik

et al. 2021

Aswan University Journal of Environmental Studies

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Obesity and its associated metabolic disorders are considered a growing global epidemic. Curcumin is used as a flavoring agent and food colorant, this polyphenol has been shown to possess many pharmacological properties. The current study was and designed to assess the protective effect of curcumin extract on HFD-induced obese rats. Thirty male albino rats were used in the current study and divided into five groups; control Diet group (CD), High Fat Dietgroup (HFD), High Fat Diet + curcumin (HFDC), Vegetable Diet group (VEG) and Vegetable Diet group + Curcumin (VEGC). Body weight was measured 2 times per week during the experiment period (56 days); specimens from kidneys were taken for histopathological studies. The results showed the body weight of HFD-group was increased while decreased in both HFDC and VEG-group. Moreover, severe histopathological changes of kidney were detected in the HFD-group. We conclude, treatment with curcumin extract was effectively alleviated the obesity and obesity induced renal pathology.

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Section: 2-histopathological Findingssupporting

confidence: 88%

Therapeutic Effects of Curcumin against Obesity and Obesity Induced Renal Pathology in Experimental Animal Models

El-Kader

Awadalla

Abdelsadik

et al. 2021

Aswan University Journal of Environmental Studies

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“…Our team dedicated its efforts to the development of anti-inflammatory drugs and, based on our previous work, a series of chemical modifications on curcumin have been performed, obtaining several curcumin analogues with excellent anti-inflammatory activity. C66 used in this work is a representative compound among them [ 9 , 15 , 16 , 17 ]. The ability of C66 to potentially abolish the inflammatory TME in pancreatic cancer was evaluated in this work, and the results revealed that the treatment with C66 significantly reduced the inflammatory factors.…”

Section: Discussionmentioning

confidence: 99%

Curcumin Derivative C66 Suppresses Pancreatic Cancer Progression through the Inhibition of JNK-Mediated Inflammation

et al. 2022

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Pancreatic adenocarcinoma is by far the deadliest type of cancer. Inflammation is one of the important risk factors in tumor development. However, it is not yet clear whether deterioration in pancreatic cancer patients is related to inflammation, as well as the underlying mechanism. In addition, JNK is abnormally activated in pancreatic cancer cells and the JNK inhibitor C66 reduces the inflammatory microenvironment in the tumor. Therefore, the aim of this study was to evaluate the role of C66 in the proliferation and migration of pancreatic cancer. Our results showed that various inflammatory cytokines, such as IL-1β, IL-6, IL-8, and IL-15, were more expressed in pancreatic cancer than in the matching normal tissue. Furthermore, C66, a curcumin analogue with good anti-inflammatory activity, inhibited the proliferation and migration of pancreatic cancer cells in a dose-dependent manner, and effectively inhibited the expression of the above inflammatory factors. Our previous research demonstrated that C66 prevents the inflammatory response by targeting JNK. Therefore, in this study, JNK activity in pancreatic cancer cells was investigated, revealing that JNK was highly activated, and the treatment with C66 inhibited the phosphorylation of JNK. Next, shJNK was used to knockdown JNK expression in pancreatic cancer cells to further confirm the role of JNK in the proliferation and migration of this tumor, as well as in the inflammatory tumor microenvironment (TME). The results demonstrated that JNK knockdown could significantly inhibit the proliferation and migration of pancreatic cancer. Moreover, the low JNK expression in pancreatic cancer cells significantly inhibited the expression of various inflammatory factors. These results indicated that C66 inhibited the progression of pancreatic cancer through the inhibition of JNK-mediated inflammation.

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“…Thus, Xiao et al conducted another in vitro and in vivo study of DZG-cyclohexanone hybrid 103 (Figure 18) on suppressing pro-inflammatory cytokines, adhesion molecules, and chemokines in bronchoalveolar lavage fluid (BALF). [72] Compound 103 decreased the mRNA levels of inflammatory cytokines gene expression such as TNF-a, IL-6, IL-1B, and COX-2 in LPS-induced mouse lung tissues. Additionally, an in vitro anti-inflammatory activity research investigation of 103 revealed that it was prevented LPS-induced ALI via JNK phosphorylation pathways, edema, and protein exudation.…”

Section: Chemistryselectmentioning

confidence: 91%

The Multi‐Biological Targeted Role of Dehydrozingerone and its Analogues

et al. 2022

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Curcumin (Cur) has shown its potential in the treatment of a wide variety of ailments. As a result, several investigations on curcumin have been conducted in vitro, in vivo, and in clinical trials. Regrettably, researchers have largely lost interest in this excellent scaffold due to its chemical instability, poor solubility, and rapid metabolism, which directly affect its pharmacological properties. Alternatively, the researchers are working on it to improve the solubility and biological half-life, it is one of the most researched natural phytochemical to date. Among these, Dehydrozingerone (DZG), a curcumin half structure has garnered considerable research interest due to a wide spectrum of its biological activities. Thus, this study offers insight into the pharmacological activity of modified DZG conjugates (incorporate multiple effective modifications to the various positions), which have been developed since 2016. Additionally, the structure-activity relationship (SAR) of DZG hybrids was illustrated for their specific pharmacological properties. This review presents an update for the scientific community, which could assist in addressing the gaps, challenges and pharmacological aspects of DZG.

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Curcumin analogue C66 attenuates obesity-induced renal injury by inhibiting chronic inflammation

Cited by 20 publications

References 43 publications

Therapeutic Effects of Curcumin against Obesity and Obesity Induced Renal Pathology in Experimental Animal Models

Therapeutic Effects of Curcumin against Obesity and Obesity Induced Renal Pathology in Experimental Animal Models

Curcumin Derivative C66 Suppresses Pancreatic Cancer Progression through the Inhibition of JNK-Mediated Inflammation

The Multi‐Biological Targeted Role of Dehydrozingerone and its Analogues

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