Curcumin and its promise as an anticancer drug: An analysis of its anticancer and antifungal effects in cancer and associated complications from invasive fungal infections

Chen, Jin; He, Zheng-Min; Wang, Fengling; Zhang, Zhengsheng; Liu, Xiuzhen; Zhai, Dandan; Chen, Weidong

doi:10.1016/j.ejphar.2015.12.038

Cited by 78 publications

(45 citation statements)

References 120 publications

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“…Many reports considered curcumin to be an effective antioxidant against oxidative damage [13-17]. Curcumin has been shown to exert anti-inflammatory effects in various acute and chronic diseases such as hepatic diseases [13], Huntington disease [14], diabetes [15, 17], cardiovascular disease [17], cancer [18], and so on. Curcumin exerts its chemopreventive effects by promoting tumor apoptosis, inhibiting proliferation and antiangiogenesis, scavenging reactive oxidative species, and reducing the inflammatory molecules in cancer cells [18].…”

Section: Discussionmentioning

confidence: 99%

“…Curcumin has been shown to exert anti-inflammatory effects in various acute and chronic diseases such as hepatic diseases [13], Huntington disease [14], diabetes [15, 17], cardiovascular disease [17], cancer [18], and so on. Curcumin exerts its chemopreventive effects by promoting tumor apoptosis, inhibiting proliferation and antiangiogenesis, scavenging reactive oxidative species, and reducing the inflammatory molecules in cancer cells [18]. In Chongtham and Agrawal’s study [14], they provided evidence that curcumin significantly ameliorates disease symptoms in a Drosophila model of Huntington disease by suppressing cell death and that it can be a key to halting the progression of Huntington disease with the least side effects.…”

Section: Discussionmentioning

confidence: 99%

“…Curcumin, a yellow curry pigment isolated from turmeric powder, has been reported to have a wide range of pharmacological effects, such as antioxidant [13-17], anti-inflammatory [13-15, 17, 18], antitumor [18, 19], scavenging reactive oxidative species [18], antiangiogenesis [18], modulating apoptosis [14, 18, 20], neuroprotective [21], inhibiting proliferation [22], antihyperglycemic [23], and so on. Curcumin has been used to treat DM in many Asian countries like China and India for a long time.…”

Section: Introductionmentioning

confidence: 99%

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Curcumin Alleviates Diabetic Retinopathy in Experimental Diabetic Rats

Yang

Feng

et al. 2018

Ophthalmic Res

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Purpose: To investigate the potential protective effects of curcumin on the retina in diabetic rats. Methods: An experimental diabetic rat model was induced by a low dose of streptozotocin combined with a high-energy diet. Rats which had blood glucose levels ≥11.6 mmol/L were used as diabetic rats. The diabetic rats were randomly divided into 3 groups: diabetic rats with no treatment (DM), diabetic rats treated with 100 mg/kg curcumin (DM + Cur 100 mg/kg), and diabetic rats treated with 200 mg/kg curcumin (DM + Cur 200 mg/kg). Curcumin was orally administered daily for 16 weeks. After 16 weeks of administration, the rats were euthanized, and eyes were dissected. Retinal histology was examined, and the thickness of the retina was measured. Ultrastructural changes of retinal ganglion cells, inner layer cells, retinal capillary, and membranous disks were observed by electron microscopy. Malondialdehyde, superoxide dismutase, and total antioxidant capacity were measured by ELISA. Expression levels of vascular endothelial growth factor (VEGF) in retina tissues were examined by immunohistochemical staining and ELISA. Expression levels of Bax and Bcl-2 in retina tissues were determined by immunohistochemical staining and Western blotting. Results: Curcumin reduced the blood glucose levels of diabetic rats and decreased diabetes-induced body weight loss. Curcumin prevented attenuation of the retina in diabetic rats and ameliorated diabetes-induced ultrastructure changes of the retina, including thinning of the retina, apoptosis of the retinal ganglion cells and inner nuclear layer cells, thickening of retinal capillary basement membrane and disturbance of photoreceptor cell membranous disks. We also found that curcumin has a strong antioxidative ability in the retina of diabetic rats. It was observed that curcumin attenuated the expression of VEGF in the retina of diabetic rats. We also discovered that curcumin had an antiapoptotic effect by upregulating the expression of Bcl-2 and downregulating the expression of Bax in the retina of diabetic rats. Conclusions: Taken together, these results suggest that curcumin may have great therapeutic potential in the treatment of diabetic retinopathy which could be attributed to the hypoglycemic, antioxidant, VEGF-downregulating and neuroprotection properties of curcumin.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Curcumin Alleviates Diabetic Retinopathy in Experimental Diabetic Rats

Yang

Feng

et al. 2018

Ophthalmic Res

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“…1). CUR has gained immense interest in the scientific community due to its antibacterial [1] , antifungal [2] antiviral [3] , anticancer [4] , antiinflammatory [5] , antimalarial [6] , antioxidant [7] and wound healing [8] properties. Asian countries like India and China have used turmeric as a traditional medicine for nearly 2000 y in the form of a paste or in oral form to treat various ailments of skin and illnesses successfully until the modern medicine found it prominent in the last two centuries.…”

Section: Review Articlementioning

confidence: 99%

Multifaceted Role of a Marvel Golden Molecule, Curcumin: a Review

Moselhy¹,

Razvi²,

Hasan³

et al. 2018

pharmaceutical-sciences

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Moselhy, et al.: Multifaceted Role of CurcuminCurcumin is chemically known as diferuloylmethane, which is an important nutraceutical obtained from the yellow spice Curcuma longa. It has been used traditionally as a folklore medicine in countries like India, China and Thailand for nearly 2000 years without any prior knowledge of the mechanism of action. Cellbased studies and clinical trials that have been reported so far have provided evidence that curcumin could be effectively used as antimicrobial, anticancer, antidiabetic, antiinflammatory, antimalarial and antioxidant. There are more than 9400 articles published on this "magical molecule" till date. Furthermore, nearly 100 clinical trials have been done using curcumin, which demonstrated safety, efficacy and prophylactic activity of curcumin. On the molecular level, curcumin has shown to modulate several crucial and significantly interlinked pathways in rendering an optimistic outcome against life-threatening diseases like cancer, diabetes, lupus nephritis, and other autoimmune and neurodegenerative diseases. In this communication, the chemical structure, biological properties and possible molecular targets of curcumin have been reviewed along with some recent developments in drug delivery systems of curcumin.

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“…울금(Curcuma Longa)의 주요 성분인 curcumin ((1E,6E)-1,7-Bis(4-hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione)은 동서고금을 막론하고 질병 치료에 널리 활용된 생리 활성 물질이다 [2,16] Fig. 2A and 2C).…”

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Molecular Docking Affinity Comparison of Curcumin and Nano-micelled Curcumin with Natural Sea Salt on Transthyretin

Kim¹,

Song²

2016

Journal of Life Science

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In this study, nano-micelled curcumin was produced with natural sea salt with a view to comparing the in silico molecular binding affinity of pure curcumin compound to the active site of transthyretin. Using an optical light microscope and an electron microscope, it was found that the structure of the surface and the cross-section of nano-micelled curcumin was significantly different from natural sea salt. In particular, the crystal structure and nano-components in the nano-micelled curcumin were united, and the layer was more strongly stabilized than untreated salts. In the virtual 3D structure, in silico molecular docking study, the ligand binding affinity of nano-micelled curcumin to the transthyretin active site was found to be higher than that of pure curcumin. In addition, a nano-micelled curcumin formula interacted with more amino acid residues of transthyretin domains. The pharmacophore feature of the nano-micelled curcumin also showed more condensed and constrained features than normal curcumin. These results suggest that nano-micelled curcumin may effectively bind to and stabilize transthyretin, thereby regulating transthyretin-related physiological diseases. Collectively, the nano-micelled curcumin process suggests that normal curcumin can be modified more efficiently into the novel bio-functional chemical formula to stabilize the transthyretin structure. Therefore, the nano-micelled curcumin process can be applied to the field of the regulation of Alzheimer's disease.Key words : Binding affinity, curcumin, in silico study, nano-micelling, transthyretin *Corresponding author *Tel : +82-10-4527-3736, Fax : +82-54-420-4461 *E-mail : channok@naver.com This is an Open-Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Curcumin and its promise as an anticancer drug: An analysis of its anticancer and antifungal effects in cancer and associated complications from invasive fungal infections

Cited by 78 publications

References 120 publications

Curcumin Alleviates Diabetic Retinopathy in Experimental Diabetic Rats

Curcumin Alleviates Diabetic Retinopathy in Experimental Diabetic Rats

Multifaceted Role of a Marvel Golden Molecule, Curcumin: a Review

Molecular Docking Affinity Comparison of Curcumin and Nano-micelled Curcumin with Natural Sea Salt on Transthyretin

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