Curcumin and neurodegenerative diseases

Monroy, Adriana; Lithgow, Gordon J.; Alavez, Silvestre

doi:10.1002/biof.1063

Cited by 150 publications

(93 citation statements)

References 134 publications

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“…Up until now, clinical trials carried out on humans affected by AD or by mild cognitive impairment have not provided results corroborating Cur efficacy, but several studies are still ongoing (for a review, see [205]).…”

Section: The Anti-amyloid Properties Of Natural Phenols and Polyphmentioning

confidence: 99%

Protein Folding and Aggregation into Amyloid: The Interference by Natural Phenolic Compounds

Stefani

Rigacci

2013

IJMS

192

127

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Amyloid aggregation is a hallmark of several degenerative diseases affecting the brain or peripheral tissues, whose intermediates (oligomers, protofibrils) and final mature fibrils display different toxicity. Consequently, compounds counteracting amyloid aggregation have been investigated for their ability (i) to stabilize toxic amyloid precursors; (ii) to prevent the growth of toxic oligomers or speed that of fibrils; (iii) to inhibit fibril growth and deposition; (iv) to disassemble preformed fibrils; and (v) to favor amyloid clearance. Natural phenols, a wide panel of plant molecules, are one of the most actively investigated categories of potential amyloid inhibitors. They are considered responsible for the beneficial effects of several traditional diets being present in green tea, extra virgin olive oil, red wine, spices, berries and aromatic herbs. Accordingly, it has been proposed that some natural phenols could be exploited to prevent and to treat amyloid diseases, and recent studies have provided significant information on their ability to inhibit peptide/protein aggregation in various ways and to stimulate cell defenses, leading to identify shared or specific mechanisms. In the first part of this review, we will overview the significance and mechanisms of amyloid aggregation and aggregate toxicity; then, we will summarize the recent achievements on protection against amyloid diseases by many natural phenols.

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Section: The Anti-amyloid Properties Of Natural Phenols and Polyphmentioning

confidence: 99%

Protein Folding and Aggregation into Amyloid: The Interference by Natural Phenolic Compounds

Stefani

Rigacci

2013

IJMS

192

127

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“…Curcumin was reported to affect the amyloidb pathway by reducing the formation of amyloid-b fibrils and inhibiting its aggregation (Sahni et al, 2011). It also exhibits cytoprotective and anti-inflammatory properties through protection of the cells against amyloid-b-induced toxicity and reduction of the expression of cytokines and chemokines, with improvement in memory and cognitive defects, leading to reversal of neurodegeneration (Agrawal et al, 2010;Sahni et al, 2011;Monroy et al, 2013). Similarly, resveratrol was reported to affect the amyloid-b pathway by reducing the production of amyloid-b peptides and remodeling of the soluble oligomers and fibrils into non-toxic forms of amyloid-b, in addition to its cytoprotective actions and reduction of cognitive defects (Sahni et al, 2011).…”

Section: Introductionmentioning

confidence: 99%

Development of an optimized hyaluronic acid-based lipidic nanoemulsion co-encapsulating two polyphenols for nose to brain delivery

Nasr

2015

Drug Delivery

170

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RESEARCH ARTICLEDevelopment of an optimized hyaluronic acid-based lipidic nanoemulsion co-encapsulating two polyphenols for nose to brain delivery Maha NasrDepartment of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Ain Shams University, Cairo, Egypt AbstractThe development of mucoadhesive lipidic nanoemulsion based on hyaluronic acid, co-encapsulating two polyphenols (resveratrol and curcumin) for the transnasal treatment of neurodegenerative diseases was attempted in the current manuscript. Nanoemulsions were prepared by the spontaneous emulsification method, and were characterized for their particle size, zeta potential, mucoadhesive strength and morphology. The selected formula was tested for its antioxidant potential, in vitro and ex vivo release of the two polyphenols, safety on nasal mucosa and in vivo quantification of the two drugs in rat brains. Its stability was tested by monitoring the change in particle size, zeta potential, drugs' content and antioxidant potential upon storage for 3 months. The optimized hyaluronic acid based nanoemulsion formula displayed a particle size of 115.2 ± 0.15 and a zeta potential of À23.9 ± 1.7. The formula displayed a spherical morphology and significantly higher mucoadhesive strength compared to its non mucoadhesive counterpart. In addition, the nanoemulsion was able to preserve the antioxidant ability of the two polyphenols and protect them from degradation. Diffusion controlled release of the two drugs was achievable till 6 hours, with an ex vivo flux across sheep nasal mucosa of 2.86 and 2.09 mg/cm 2 hr for resveratrol and curcumin, respectively. Moreover, the mucoadhesive nanoemulsion was safe on nasal mucosa and managed to increase the amounts of the two polypehnols in the brain (about 7 and 9 folds increase in AUC 0-7 h for resveratrol and curcumin, respectively). Hyaluronic acid based lipidic nanoemulsion proved itself as a successful carrier enhancing the solubility, stability and brain targetability of polyphenols.

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“…It was found that those who consumed curry very often, at least once a week had better cognition which is different from a previous study, which noted that regular use of low or moderate curry consumption, at least once in six months had significant effect on cognition 12 . An experimental study with rats reported that low dose of curcumin reduced β-amyloid and plaque burden 6 . This could be the plausible reason for the cognitive protection of curcumin.…”

Section: Resultsmentioning

confidence: 99%

Untitled

2017

IJPSR

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ABSTRACT:Cognitive impairment in elderly is a growing public health concern, and is mainly caused by dementia of various etiologies. Hence, it is important to explore possible measures to mitigate the risk of dementia. Curcumin, active ingredient of turmeric (Curcuma longa) is used in curry and has shown protective effect on cognition. This study aims to explore the association between curcumin consumption in curry form and cognitive function in elderly population. This cross-sectional study was conducted in 14 randomly selected residential homes for elderly in Ipoh, Malaysia. A total of 162 subjects aged ≥ 60 years without major physical and mental health problems were selected. The variables included demographic variables, fitness and social activities and frequency of curry consumption. Association of cognitive function with curry consumption and other variables was tested using Mini-Mental State Examination (MMSE). The data was analysed by chi-square and logistic regression using SPSS17.0. Curry consumption, at least once a week was a significant protective factor for cognition based on logistic regression analysis (OR = 0.152; 95% CI: 0.038-0.614; p = 0.008) when combined with other variables like higher level of education (secondary level, p = 0.002; college or university level, p = 0.016) and engagement in fitness activities (p = 0.010). Females (OR = 4.085; 95% CI: 1.559-10.705) and higher age group i.e.75 years and above (OR = 4.441; 95% CI: 1.656-11.907) were at significant risk of cognitive impairment.

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Curcumin and neurodegenerative diseases

Cited by 150 publications

References 134 publications

Protein Folding and Aggregation into Amyloid: The Interference by Natural Phenolic Compounds

Protein Folding and Aggregation into Amyloid: The Interference by Natural Phenolic Compounds

Development of an optimized hyaluronic acid-based lipidic nanoemulsion co-encapsulating two polyphenols for nose to brain delivery

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