Curcumin and ustekinumab cotherapy alleviates induced psoriasis in rats through their antioxidant, anti-inflammatory, and antiproliferative effects

Mousa, Ayman; Alhumaydhi, Fahad A.; Abdellatif, Ahmed A. H.; Abdulmonem, Waleed Al; Alkhowailed, Mohammad S.; Alsagaby, Suliman A.; Rugaie, Osamah Al; Alnuqaydan, Abdullah M; Aljohani, Abdullah S. M.; Aljasir, Mohammad; Alwashmi, Ameen S. S.; Soliman, Khaled E.A.; Yosof, Mohamad Y. R.; Elsheikh, Sayed Y.; Babiker, Ali Yousif; Alsuhaibani, Sultan A.; Hegazy, Ahmed Medhat; Seleem, Hanan S.

doi:10.1080/15569527.2021.2003377

Cited by 6 publications

(4 citation statements)

References 43 publications

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“…The hair of the control group (GA), SN group (GB), and SN-SV group (GC) was shaved at day zero to apply the used creams on the skin of all rats. GB and GC were subjected to wound infliction from the dorsal skin surface of each rat at day zero under local anesthesia by a sharp punch biopsy to create a full-thickness surgical wound (0.8 × 0.8 cm) [32]. Vaseline cream was applied to the shaved skin of GA, whereas the wounded skin of GB and GC subgroups were treated with the SN and SN-SV creams, respectively.…”

Section: In Vivo Experimental Study To Investigate the Wound Healing ...mentioning

confidence: 99%

“…Another punch biopsy was excised from the dorsal skin of all rats after applying the creams for 5 days (GA1, GB1, and GC1), 11 days (GA2, GB2, and GC2), and 15 days (GA3, GB3, and GC3), respectively. The skin biopsies from all rats were investigated by the standard histopathological (HP) methods of hematoxylin and eosin (H&E) to evaluate the wound healing ability, and proliferating cell nuclear antigen (PCNA) immunostaining was used to evaluate the extent of epidermal re-epithelialization by the SN-SV cream in the GC subgroups compared to the SN cream in the GB subgroups following the skin injury [32,33]. The excised skin specimens (1 cm 2 ) from all subgroups were preserved in 10% normal-buffered formalin and processed to obtain five µm-thick sections.…”

Section: In Vivo Experimental Study To Investigate the Wound Healing ...mentioning

confidence: 99%

“…following the skin injury [32,33]. The excised skin specimens (1 cm 2 ) from all subgroups were preserved in 10% normal-buffered formalin and processed to obtain five µm-thick sections.…”

Section: Size and Zeta Potentialmentioning

confidence: 99%

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Eco-Friendly Synthesis of Silver Nanoparticles by Nitrosalsola vermiculata to Promote Skin Wound Healing

et al. 2023

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Eco-friendly synthesis of silver nanoparticles (SN) by using a naturally occurring plant, such as Nitrosalsola (Salsola) vermiculata (SV), could be a novel way for appropriate wound healing. AgNO3 was reduced by SV to produce safe SN (SN-SV) extract and hasten the wound healing process. The obtained SN-SV were characterized by size, charge, wavelength, and surface morphology. The optimized formulation was dispersed in O/W cosmetic cream. Then, it was characterized in terms of pH, viscosity, homogeneity, and permeability. The ex vivo and in vivo studies have been conducted in a rat animal model to assess the potential of SN-SV cream on skin tissue regeneration. A skin punch biopsy was obtained to investigate the histopathological (HP) changes in the skin lesions of all rats by the H&E staining and PCNA immunostaining methods. The skin wounds in all subgroups were examined on days 5, 11, and 15 to analyze the effectiveness of SN-SV cream for treating surgical skin wounds. The prepared SN-SV had a particle size of 37.32 ± 1.686 nm, a charge of −1.4 ± 0.7 mV, non-aggregated SN-SV, and a λmax of 396.46 nm. The formed SN-SV cream showed a pH near the skin’s pH, with suitable viscosity and homogeneity and an apparent permeability of 0.009 ± 0.001. The HP changes in the SN-SV subgroups revealed a substantial reduction in wound size and improvement in wound granulation tissue formation and epidermal re-epithelialization (proliferation) compared to the healing in the SN subgroups. The current work revealed that SN-SV could be a novel skin-wound-healing agent with a practical application as a wound-healing platform.

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Section: In Vivo Experimental Study To Investigate the Wound Healing ...mentioning

confidence: 99%

Section: In Vivo Experimental Study To Investigate the Wound Healing ...mentioning

confidence: 99%

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Eco-Friendly Synthesis of Silver Nanoparticles by Nitrosalsola vermiculata to Promote Skin Wound Healing

et al. 2023

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“…43 Furthermore, Mousa et al demonstrated that a combination therapy of CUR and ustekinumab significantly alleviates symptoms in imiquimod-induced psoriasis in a rat model more effectively than ustekinumab monotherapy by synergistically reducing proinflammatory cytokines such as tumor necrosis factor-alpha (TNF-α), IL-17, IL-12 subunit p40, and IL-23, and enhancing levels of antioxidant biomarkers, including superoxide dismutase (SOD), glutathione peroxidase (GPx), and catalase (CAT), indicating a promising, cost-effective approach for improving psoriasis treatment outcomes. 44 Thus, the growing evidence supporting CUR's efficacy in psoriasis treatment reflects an encouraging trend towards blending traditional and modern therapeutic approaches. CUR's anti-inflammatory and immunomodulatory effects, particularly its influence on the IL-6/STAT3 pathway and the gut microbiome, highlight its potential as both an adjunct and an alternative to conventional psoriasis therapies.…”

Section: Introductionmentioning

confidence: 99%

Advancements in Dermatological Applications of Curcumin: Clinical Efficacy and Mechanistic Insights in the Management of Skin Disorders

Mo,

Yuan,

Guan

et al. 2024

CCID

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Curcumin, derived from Curcuma longa (turmeric), exhibits significant potential in dermatology, addressing conditions like atopic dermatitis, psoriasis, chronic wounds, skin cancer, and infections through its anti-inflammatory, antioxidant, anticancer, and antimicrobial properties. This review synthesizes evidence on curcumin's mechanisms, including modulation of immune responses and promotion of wound healing, showcasing its efficacy in reducing inflammation, cytokine levels, and enhancing skin barrier functions. Studies highlight curcumin's ability to selectively target tumor cells, suggesting a multifaceted approach to cancer therapy with minimal side effects. Despite promising therapeutic benefits, challenges remain in bioavailability, potency, and targeted delivery, underscoring the need for further research to optimize dosages, delivery methods, and assess long-term safety. The integration of curcumin into dermatological practice requires a balanced consideration of evidence-based efficacy and safety. Curcumin's comprehensive utility in dermatology, coupled with the necessity for advanced scientific exploration, emphasizes the importance of combining traditional knowledge with contemporary research to improve patient care in dermatology. This approach could significantly enhance outcomes for individuals with skin-related conditions, marking curcumin as a versatile and promising agent in the field.

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Evaluation of the anticancer activity of Origanum Marjoram as a safe natural drink for daily use

Abdellatif,

Alsharidah

2023

Drug Development and Industrial Pharmacy

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Curcumin and ustekinumab cotherapy alleviates induced psoriasis in rats through their antioxidant, anti-inflammatory, and antiproliferative effects

Cited by 6 publications

References 43 publications

Eco-Friendly Synthesis of Silver Nanoparticles by Nitrosalsola vermiculata to Promote Skin Wound Healing

Eco-Friendly Synthesis of Silver Nanoparticles by Nitrosalsola vermiculata to Promote Skin Wound Healing

Advancements in Dermatological Applications of Curcumin: Clinical Efficacy and Mechanistic Insights in the Management of Skin Disorders

Evaluation of the anticancer activity of Origanum Marjoram as a safe natural drink for daily use

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