Curcumin as a multidrug resistance modulator — A quick review

The Modulation of Drug Efflux Transporter by Curcumin in McF7 Breast Cancer Cells After Repeated Exposure of Endoxifen and Estradiol

“…CM, a polyphenol derived from C. longa, has a wide range of beneficial properties as a chemotherapeutic agent and modulator of ABC efflux transporters [12,13]. A recent study also showed that CM administered together with TMX increased the anticancer activity, as compared with TMX alone.…”

“…To overcome the emergence of the resistance phenomenon, many groups have attempted to generate inhibitors of drug efflux transporters [12]. Curcumin (CM), a natural diphenolic compound from Curcuma longa, exerts antiproliferative effects and modulates the activities of drug efflux transporters [12,13].…”

“…To overcome the emergence of the resistance phenomenon, many groups have attempted to generate inhibitors of drug efflux transporters [12]. Curcumin (CM), a natural diphenolic compound from Curcuma longa, exerts antiproliferative effects and modulates the activities of drug efflux transporters [12,13]. Therefore, the aim of the present study was to determine whether CM can prevent the decreased sensitivity of BC cells to E, when administered together with estradiol (β-E2) and whether the underlying mechanism involves modulation of drug efflux transporters.…”

Development of novel application of 3,3′-diindolylmethane: sensitizing multidrug resistance human breast cancer cells to γ-irradiation

“…Although many different approaches have been developed including MDR modulators, new anticancer drugs, nanocarriers and RNAi therapy, all of these approaches have advantages and limitations (Xing et al 2013;Xue et al 2013;Deng et al 2014). As such, it is still a challenge for researchers to develop effective strategies to overcome MDR.…”

Nanopotentiated combination cancer therapy: Chemotherapeutic and chemosensitizer (2C approach)

“…A number of plant based bioactives such as curcumin, resveratrol, genistein, CAPE, emodin, flavopiridol, silymarin have been investigated for their chemosensitization effect and have reportedly elicited reversal of chemoresistance through simultaneous modulation of multiple pathways which are responsible for tumorigenesis [21][22][23][24]. Earlier reports have suggested that these bioactives have multiple foci of action both direct and indirect [25].…”