Curcumin as a regulator of epigenetic events

Teiten, Marie-Hélène; Dicato, Mario; Diederich, Marc

doi:10.1002/mnfr.201300201

Cited by 148 publications

(87 citation statements)

References 113 publications

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“…Despite the previously demonstrated antitumor activity of curcumin, the mechanism underlying this effect remains elusive. Epigenetic changes induced by curcumin may mediate its effects (30). Previous studies have revealed that the expression of a number of miRNAs is altered by curcumin.…”

Section: Discussionmentioning

confidence: 99%

Curcumin induces apoptotic cell death in human pancreatic cancer cells via the miR-340/XIAP signaling pathway

Yang

Zhao

2017

Oncology Letters

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Abstract. The natural compound curcumin has previously been reported to inhibit pancreatic cancer cell growth. However, the underlying molecular mechanisms underlying this effect remain unclear. Results from the present study demonstrate that the miR-340/X-linked inhibitor of apoptosis (XIAP) signaling pathway mediates curcumin-induced pancreatic cancer cell apoptosis. miR-340 was identified to be significantly upregulated following curcumin treatment. In addition, treatment with curcumin or miR-340 induced pancreatic cancer cell apoptosis, whereas silencing endogenous miR-340 significantly inhibited the proapoptotic effect of curcumin. A luciferase reporter assay and western blot analysis identified that the oncogene XIAP is a direct target of miR-340. Furthermore, curcumin treatment significantly reduced XIAP expression, an effect that was rescued by treatment with anti-miR-340. The results of the present study suggest that the miR-340/XIAP signaling pathway is a downstream target of curcumin that mediates its proapoptotic effects on pancreatic cancer cells. This may provide the basis for novel treatment strategies for patients with pancreatic cancer.

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Section: Discussionmentioning

confidence: 99%

Curcumin induces apoptotic cell death in human pancreatic cancer cells via the miR-340/XIAP signaling pathway

Yang

Zhao

2017

Oncology Letters

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“…To study the epigenetic regulation of cccDNA in HBeAg variants, initially we used the deacetylase inhibitor TSA, a potent inhibitor of HDAC, and curcumin, a potent hypomethylating agent (Delcuve et al, 2012;Teiten et al, 2013). Both agents induced a 2 to 3-fold rapid increase in nuclear cccDNA accumulation.…”

Section: Discussionmentioning

confidence: 99%

Hepatitis B virus basal core promoter mutations show lower replication fitness associated with cccDNA acetylation status

et al. 2016

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 The precore mutations have no significant effect on viral replication.  Viral replication capacity of mutants parallels cccDNA acetylation status.  cccDNA is a target for methylation and is accompanied by DNMT1 upregulation.  HBV mutants modulate viral replication via cccDNA epigenetic control. 3 AbstractIn chronic hepatitis B virus (HBV) infection, variants with mutations in the basal core promoter (BCP) and precore region predominate and associate with more severe disease forms. Studies on their effect on viral replication remain controversial. Increasing evidence shows that epigenetic modifications of cccDNA regulate HBV replication and disease outcome. Here we determined the transcription and viral replication efficiency of welldefined BCP and precore mutations and their effect on cccDNA epigenetic control. HBV monomers bearing BCP mutations A1762T/G1764A and A1762T/G1764A/C1766T, and precore mutations G1896A, G1899A and G1896A/G1899A, were transfected into HepG2 cells using a plasmid-free approach. Viral RNA transcripts were detected by Northern blot hybridization and RT PCR, DNA replicative intermediates by Southern blotting and RT PCR, and viral release was measured by ELISA. Acetylation of cccDNA-bound histones was assessed by Chromatin ImmunoPrecipitation (ChIP) assay and methylation of cccDNA by bisulfite sequencing. BCP mutations resulted in low viral release, mRNA transcription and pgRNA/cccDNA ratios that paralleled the acetylation of cccDNA-bound H4 histone and inversely correlated with the HDAC1 recruitment onto cccDNA. Independently of the mutations, cccDNA was a target for methylation, accompanied by the upregulation of DNMT1 expression and DNMT1 recruitment onto cccDNA. Our results suggest that BCP mutations decrease viral replication capacity possibly by modulating the acetylation and deacetylation of cccDNA-bound histones while precore mutations do not have a significant effect on viral replication. These data provide evidence that epigenetic factors contribute to the regulation of HBV viral replication.

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“…Recent papers demonstrated that curcumin can induce epigenetic alteration such as changes in DNA methylation, histone modifications and modulation of several oncogenic and tumor suppressor microRNAs (miRNAs) expression such as miR-21, miR-20a, miR-17-5p, and miR-27a and miR-34 a/c [20].…”

Section: Curcuminoidsmentioning

confidence: 99%

Natural Compounds: Molecular Weapons against Leukemia’s

Taverna¹,

Corrado

2017

J Leuk

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Nowadays cancer is one of the main reasons of death all over the world and it is estimated that deaths caused by cancer will grow dramatically in the next decades. Even if chemotherapy is the election therapy for solid tumors, as well as leukemias and lymphomas, cancer treatments are in continuous evolution trying to solve the problem of resistance mainly due to low accumulation of the drug in tumor cells (MDR). Natural compounds represent a valid alternative to treat several disease and recently the scientific community focus on these natural compounds and plant metabolites with therapeutic activities and low toxicities compared with synthetic ones.A combination therapy, that join conventional chemotherapy with natural plant metabolites, is now considered a new promising strategy to overcome MDR and reduce cellular toxicity; in particular, in leukemia due to its very complex origin and development of leukemogenesis.Here, we want to summarize and update the recent applications of natural compounds in the treatment of leukemia.

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Curcumin as a regulator of epigenetic events

Cited by 148 publications

References 113 publications

Curcumin induces apoptotic cell death in human pancreatic cancer cells via the miR-340/XIAP signaling pathway

Curcumin induces apoptotic cell death in human pancreatic cancer cells via the miR-340/XIAP signaling pathway

Hepatitis B virus basal core promoter mutations show lower replication fitness associated with cccDNA acetylation status

Natural Compounds: Molecular Weapons against Leukemia’s

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