Curcumin Attenuates Asthmatic Airway Inflammation and Mucus Hypersecretion Involving a PPARγ-Dependent NF-κB Signaling Pathway In Vivo and In Vitro

Zhu, Tao; Chen, Zhihong; Chen, Guihua; Wang, Daoxin; Tang, Shuo; Deng, Huojin; Wang, Jing; Li, Shengjin; Lan, Jing; Jin, Tao; He, Li; Deng, Xinyu; Zhang, Wei; Sun, Jiayang; Tu, Yuesheng; Luo, Wan-Ting; Li, Changyi

doi:10.1155/2019/4927430

Cited by 60 publications

(42 citation statements)

References 54 publications

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“…Curcumin (from Curcuma plants) has a strong anti-inflammatory ability in otitis media caused by NTHi infection, and it can inhibit the NTHi-mediated upregulation of C-X-C motif chemokine 5 (CXCL5) expression by activating the inhibitor of nuclear factor kappa-B kinase kinase-β (IKKβ)-inhibitor kappa B (IκBα) and p38 MAPK pathways [74]. Studies have also shown that curcumin can inhibit airway inflammation and MUC5AC secretion in asthmatic mice [75]. Whether curcumin is effective in NTHi-induced neutrophilic asthma needs further study.…”

Section: Other Anti-inflammatory Drugsmentioning

confidence: 99%

The role of NTHi colonization and infection in the pathogenesis of neutrophilic asthma

et al. 2020

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Asthma is a complex heterogeneous disease. The neutrophilic subtypes of asthma are described as persistent, more severe and corticosteroid-resistant, with higher hospitalization and mortality rates, which seriously affect the lives of asthmatic patients. With the development of high-throughput sequencing technology, an increasing amount of evidence has shown that lower airway microbiome dysbiosis contributes to the exacerbation of asthma, especially neutrophilic asthma. Nontypeable Haemophilus influenzae is normally found in the upper respiratory tract of healthy adults and is one of the most common strains in the lower respiratory tract of neutrophilic asthma patients, in whom its presence is related to the occurrence of corticosteroid resistance. To understand the pathogenic mechanism by which nontypeable Haemophilus influenzae colonization leads to the progression of neutrophilic asthma, we reviewed the previous literature on nontypeable Haemophilus influenzae colonization and subsequent aggravation of neutrophilic asthma and corticosteroid resistance. We discussed nontypeable Haemophilus influenzae as a potential therapeutic target to prevent the progression of neutrophilic asthma.

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Section: Other Anti-inflammatory Drugsmentioning

confidence: 99%

The role of NTHi colonization and infection in the pathogenesis of neutrophilic asthma

et al. 2020

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“…a study by Zhu et al, PPAR-γ activation induced an antiinflammatory effect by inhibiting the NF-κB pathway in chronic asthma models. 40 It has been also reported that RGTZ suppresses LPS-mediated inflammatory responses, indicating that PPAR-γ agonists may be effective protection against pulmonary inflammation in rats. 41 Moreover, our previous study in a chronic renal allograft dysfunction model demonstrated that PPAR-γ agonists inhibit NF-κB activation and infiltration of inflammatory cells into the interstitium.…”

Section: Discussionmentioning

confidence: 96%

Treatment with a PPAR-γ Agonist Protects Against Hyperuricemic Nephropathy in a Rat Model

Wang¹,

Deng²,

Xiong³

et al. 2020

DDDT

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Hyperuricemia is an independent risk factor for renal damage and can promote the progression of chronic kidney disease (CKD). In the present study, we employ a rat model to investigate the effects of rosiglitazone (RGTZ), a peroxisome proliferator-activated receptorgamma agonist, on the development of hyperuricemic nephropathy (HN), and we elucidate the mechanisms involved. Methods: An HN rat model was established by oral administration of a mixture of adenine and potassium oxonate daily for 3 weeks. Twenty-four rats were divided into 4 groups: sham treatment, sham treatment plus RGTZ, HN, and HN treated with RGTZ. Results: Administration of RGTZ effectively preserved renal function, decreased urine microalbumin, and inhibited interstitial fibrosis and macrophage infiltration in a rat HN model. RGTZ treatment also inhibited TGF-β and NF-κB pathway activation, decreased expression of fibronectin, collagen I, α-SMA, vimentin, MCP-1, RANTES, TNF-α, and IL-1β, and increased E-cadherin expression in the kidneys of HN rats. Furthermore, RGTZ treatment preserved expression of OAT1 and OAT3 in the kidney of HN rats. Conclusion: RGTZ attenuates the progression of HN through inhibiting TGF-β signaling, suppressing epithelial-to-mesenchymal transition, reducing inflammation, and lowering serum uric acid levels by preserving expression of urate transporters.

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“…Accumulation of a mucus plug in the airways is observed in patients with lung inflammatory diseases, and this leads to obstruction and failure of respiration. Effective treatment for mucus hypersecretion is an unmet medical demand in curtailing asthma discomfort [ 43 ]. Interestingly, fucoidans were found to attenuate goblet cell hyperplasia, enlargement of submucosal glands, and mucus hypersecretion.…”

Section: Discussionmentioning

confidence: 99%

The Role of Fucoidans Isolated from the Sporophylls of Undaria pinnatifida against Particulate-Matter-Induced Allergic Airway Inflammation: Evidence of the Attenuation of Oxidative Stress and Inflammatory Responses

Herath

Kim

et al. 2020

Molecules

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Ambient particulate matter (PM) is a critical environment pollutant that promotes the onset and aggravation of respiratory diseases such as asthma through airway inflammation and hypersecretion of mucus. In this study, we aimed to identify the effects of fucoidans isolated from sporophylls of Undaria pinnatifida on asthma symptoms such as the inflammatory response and mucus secretion using a mouse model. Balb/c mice, intraperitoneally sensitized with ovalbumin (OVA, 10 μg) dissolved in 200 µL saline and 2 mg Al(OH)3, were exposed to PM (5 mg/m3) for 7 consecutive days. In parallel, along with PM exposure, we orally administrated fucoidans (100, 400 mg/Kg) or prednisone (5 mg/Kg), an anti-inflammatory drug. We found that oral administration of fucoidans significantly attenuated PM-induced lipid peroxidation and infiltration of inflammatory cells like F4/80+ macrophages, Gr-1+ granulocytes, and CD4+ T lymphocytes. Fucoidans also attenuated the level of PM-exacerbated IL-4, a primitive cytokine released in Th2 mediated eosinophilic asthma. This further suppressed mast cell activation, degranulation and IgE synthesis of PM exposed mice. Interestingly, fucoidans attenuated PM-exacerbated mucus hypersecretion and goblet cell hyperplasia. Therefore, our results suggest that fucoidans are effective at alleviating PM-exacerbated allergic asthma symptoms by attenuating the airway inflammatory response and mucus hypersecretion.

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Curcumin Attenuates Asthmatic Airway Inflammation and Mucus Hypersecretion Involving a PPARγ-Dependent NF-κB Signaling Pathway In Vivo and In Vitro

Cited by 60 publications

References 54 publications

The role of NTHi colonization and infection in the pathogenesis of neutrophilic asthma

The role of NTHi colonization and infection in the pathogenesis of neutrophilic asthma

<p>Treatment with a PPAR-γ Agonist Protects Against Hyperuricemic Nephropathy in a Rat Model</p>

The Role of Fucoidans Isolated from the Sporophylls of Undaria pinnatifida against Particulate-Matter-Induced Allergic Airway Inflammation: Evidence of the Attenuation of Oxidative Stress and Inflammatory Responses

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