Curcumin attenuates cytoplasmic/endoplasmic reticulum stress, apoptosis and cholinergic dysfunction in diabetic rat hippocampus

Keshk, Walaa Arafa; Elseady, Walaa S.; Sarhan, Naglaa I.; Zineldeen, Doaa H.

doi:10.1007/s11011-020-00551-0

Cited by 15 publications

(10 citation statements)

References 48 publications

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“…Apoptosis can be triggered by endoplasmic reticulum (ER) stress in which glucose-regulated protein 78 (GRP78), CCAAT-enhancerbinding protein homologous protein (CHOP) and activating transcription factor 4 (ATF4) are induced by unfold protein response (UPR) to ameliorate ER stress by stimulation of apoptosis (Di Conza and Ho, 2020). Curcumin stimulates neuroprotective effects by down-regulation of GRP78 and ATF4 to attenuate ER stress-mediated apoptosis in neuronal cells (Keshk et al, 2020). Noteworthy, curcumin-mediated Notch upregulation protects neuronal cells against cytotoxic agents such as bisphenol A (BPA) (Tandon et al, 2020).…”

Section: Curcumin and Molecular Pathways And Mechanismsmentioning

confidence: 99%

Toward Regulatory Effects of Curcumin on Transforming Growth Factor-Beta Across Different Diseases: A Review

et al. 2020

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Immune response, proliferation, migration and angiogenesis are juts a few of cellular events that are regulated by transforming growth factor-β (TGF-β) in cells. A number of studies have documented that TGF-β undergoes abnormal expression in different diseases, e.g., diabetes, cancer, fibrosis, asthma, arthritis, among others. This has led to great fascination into this signaling pathway and developing agents with modulatory impact on TGF-β. Curcumin, a natural-based compound, is obtained from rhizome and roots of turmeric plant. It has a number of pharmacological activities including antioxidant, anti-inflammatory, anti-tumor, anti-diabetes and so on. Noteworthy, it has been demonstrated that curcumin affects different molecular signaling pathways such as Wnt/β-catenin, Nrf2, AMPK, mitogen-activated protein kinase and so on. In the present review, we evaluate the potential of curcumin in regulation of TGF-β signaling pathway to corelate it with therapeutic impacts of curcumin. By modulation of TGF-β (both upregulation and down-regulation), curcumin ameliorates fibrosis, neurological disorders, liver disease, diabetes and asthma. Besides, curcumin targets TGF-β signaling pathway which is capable of suppressing proliferation of tumor cells and invading cancer cells.

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Section: Curcumin and Molecular Pathways And Mechanismsmentioning

confidence: 99%

Toward Regulatory Effects of Curcumin on Transforming Growth Factor-Beta Across Different Diseases: A Review

et al. 2020

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“…Decreased phosphorylation of eIF2 α was detected in the normal colonic mucosa of patients with UC [ 14 ]. Previous studies reported that curcumin could attenuate tissue damage and cell apoptosis induced by ERS by inhibiting PERK/eIF2 α -mediated signaling pathways [ 22 , 49 ]. Nevertheless, whether curcumin can improve intestinal barrier integrity in colitis by regulating ERS has not yet been reported.…”

Section: Discussionmentioning

confidence: 99%

Curcumin Improves Epithelial Barrier Integrity of Caco-2 Monolayers by Inhibiting Endoplasmic Reticulum Stress and Subsequent Apoptosis

Zhou

Ren

Yang

et al. 2021

Gastroenterology Research and Practice

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Curcumin is a natural polyphenol and is supposed to possess antioxidant, anti-inflammatory, anticancer, and antiapoptotic properties. Although some studies have reported the therapeutic effects of curcumin on ulcerative colitis (UC), the specific mechanism remains unclear. An in vitro coculture model of Caco-2 and differentiated THP-1 cells was established. After administration of curcumin (10 μM), Western blot analysis was performed to evaluate the protein levels of tight junction (TJ) proteins zonula occludens- (ZO-) 1 and claudin-1. Annexin V-APC/7-AAD assays and flow cytometry were conducted to assess Caco-2 cell apoptosis. The expression levels of oxidative stress and endoplasmic reticulum stress- (ERS-) related molecules were determined by Western blot analysis. Curcumin administration significantly upregulated ZO-1 and claudin-1 protein levels and reduced Caco-2 cell apoptosis. The protein levels of oxidative stress markers inducible nitric oxide synthase (iNOS) and γH2AX and ERS-induced apoptosis-related molecules C/EBP homologous protein (CHOP) and cleaved caspase-12 were significantly downregulated upon curcumin treatment. Furthermore, curcumin administration greatly blocked the protein kinase-like endoplasmic reticulum kinase- (PERK-) eukaryotic translation initiation factor 2α- (eIF2α-) activating transcription factor 4- (ATF4-) CHOP signaling pathway. Curcumin enhanced intestinal epithelial barrier integrity in the in vitro coculture model by upregulating TJ protein expressions and reducing intestinal epithelial cell apoptosis. The potential mechanisms may be suppression of ERS and subsequent apoptosis.

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“…The animals used in the experiment were divided into four equal groups, intended to keep their average live weights: Control (K), Diabetes (D), Curcumin (C), and Diabetes + Curcumin (DC). In order to expose them to diabetes, 60 mg/kg streptozotocin intraperitoneal injection was dissolved in the 0.1M citrate buffer (pH: 4.5) and was applied to the rats in the D and DC groups (Akbarzadeh et al, 2007;Maciel et al, 2013;Keshk et al, 2020). After 72 hr, induction of diabetes was verified by measuring blood glucose level via the tail vein and animals with blood glucose levels greater than 250mg /dl were considered diabetic.…”

Section: Methodsmentioning

confidence: 99%

The Effect of Curcumin on the Antioxidant System in Diabetic Rats

SALGINTAŞ

Dönmez

ÖZSAN

2022

J Hellenic Vet Med Soc

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The aim of this study was to determine the effect of oral administration of curcumin, also known as a highly effective antioxidant, which has been used as a spice in experimental diabetic rats with streptozotocin (STZ) on antioxidant system. In this research, 30 healthy adult male Wistar albino rats, were used. The animals were divided into four groups as control group (K), diabetes group (D), curcumin group (C), and diabetes + curcumin group (DC). In order to create diabetes, D and DC groups were administered 60 mg/kg STZ as a single dose by intraperitoneal injection. Curcumin (50 mg/kg live weight/day) was given orally to the C and DC groups. At the end of the experiment, Malondialdehyde (MDA), Superoxidedismutase (SOD), Glutathione (GSH), Catalase, and glucose levels were determined. The MDA level was significantly higher in the D group compared to the other groups. MDA level determined in DC group was found to be significantly lower from group D (p <0.05) while getting closer to groups K and C. It was also found that the levels of antioxidants SOD, GSH and catalase which are known to be effective against oxidative stress, were significantly apparently lower in group D compared to control groups (K and C). Again from the perspective of these parameters, when the data in group DC were evaluated, it was observed that the obtained data were getting closer to K and C or becoming similar. The blood glucose level obtained from the D group was significantly higher than the other groups. As a result, the data obtained from the research shows that curcumin, which is used in experimental diabetes-induced rats for its antioxidative and antidiabetic effects, is very helpful thanks to the positive effect in terms of the parameters followed.

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Curcumin attenuates cytoplasmic/endoplasmic reticulum stress, apoptosis and cholinergic dysfunction in diabetic rat hippocampus

Cited by 15 publications

References 48 publications

Toward Regulatory Effects of Curcumin on Transforming Growth Factor-Beta Across Different Diseases: A Review

Toward Regulatory Effects of Curcumin on Transforming Growth Factor-Beta Across Different Diseases: A Review

Curcumin Improves Epithelial Barrier Integrity of Caco-2 Monolayers by Inhibiting Endoplasmic Reticulum Stress and Subsequent Apoptosis

The Effect of Curcumin on the Antioxidant System in Diabetic Rats

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