CURCUMIN ATTENUATES LEAD (Pb)–INDUCED NEUROBEHAVIORL AND NEUROBIOCHEMICAL DYSFUNCTION: A REVIEW

Abu-Taweel, Gasem Mohammad

doi:10.22159/ijpps.2018v10i8.27191

Cited by 7 publications

(5 citation statements)

References 43 publications

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“…It is in agreement with the results of other authors [42,43]. According to Abu-Taweel [24], Cur enhanced the activity of antioxidant enzymes (SOD, CAT, and GSH) in rats against heavy metal toxicity. Jamakala and Rani [44] explained that CAT activity gets declined because of high accumulation of H 2 O 2 in the tissues and as a resulting in Cd-induced peroxidation of lipids in Cd-treated mice.…”

Section: Resultssupporting

confidence: 92%

“…Cur has been shown to possess many biological properties, for example, anti-inflammatory, anticarcinogenic, antioxidant, anticoagulant, antimutagenic, antidiabetic, antifungal, antibacterial, antiviral, anticoagulant, antiulcer, hypercholesterolemia, hypotensive, and cardioprotective [18][19][20][21][22][23]. Antioxidants play a critical role in preventing oxidative stress in the human body [24]. Cur, an antioxidant can remarkably inhibit the generation of ROS both in vitro and in vivo [25].…”

Section: Introductionmentioning

confidence: 99%

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Protective Effect of Curcuma Longa Administration on Lung of Mice Exposed to Cadmium

Sharma

Kumari

2018

Asian J Pharm Clin Res

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Objective: Cadmium (Cd) is a toxic heavy metal which is introduced into the environment by various anthropogenic and natural activities. It can cause various health problems even at low concentration by inducing oxidative damage in tissues of organisms. Nowadays, the focus has been raised toward the use of herbal treatment against the heavy metal toxicity. Hence, the present study was aimed to investigate the protective effect of curcumin (Cur) against Cd-induced toxicity in the lung of albino mice.Materials and Methods: Albino mice were divided into 4 groups and 5 mice were kept in each group. The experiment was carried out for 15 and 45 days. Group 1 mice were kept as control. Group 2 mice were given an oral dose of 1mg/kg body weight of Cd on alternate days. Group 3 mice were administered an oral dose of 1mg/kg body weight of Cd on alternate days and 100 mg/kg body weight of Cur daily. Group 4 mice were received an oral dose of 100 mg/kg body weight of Cur daily. Autopsies were done on 15 and 45 days post-treatment.Result: Biochemical observations showed an increased level of lipid peroxidation and decreased the activity of antioxidant enzymes, i.e., superoxide dismutase, catalase, and glutathione peroxidase. However, Cur administration improved the level of malondialdehyde and oxidative stress in lung tissue by its antioxidant activity. Furthermore, cotreatment of Cd and Cur ameliorated the antioxidant level.Conclusion: The results of the present experiment showed the protective action of Cur on the Cd-induced oxidative damage in the lung of mice.

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Section: Resultssupporting

confidence: 92%

Section: Introductionmentioning

confidence: 99%

Protective Effect of Curcuma Longa Administration on Lung of Mice Exposed to Cadmium

Sharma

Kumari

2018

Asian J Pharm Clin Res

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“…There are numerous reports on the event of fringe neuropathy due to interminable presentation of arsenic through drinking water. Peripheral neuritis characterized by paresthesia (shivering, deadness, appendage shortcoming, and so forth) was available in 74 (47.4%) of 156 patients of incessant arsenicosis because [42,43] of arsenic defiled water (0.5-14.2 mg/l) in West Bengal, India.…”

Section: Chronic Poisoningmentioning

confidence: 99%

Arsenic: A Harmful and Desecrate Compound for the Humans

Chandra

Saini

Gupta

2019

Asian J Pharm Clin Res

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Arsenic toxicity has become a burgeoning concern as several millions of people are exposed to this chemical through drinking water contamination by arsenic remains a major public health problem. Acute and chronic arsenic exposure through drinking water has been reported in many countries of the world, where a large proportion of drinking water is contaminated with high concentrations of arsenic. As contamination in groundwater has been found in more than 105 countries around the world, it has become the worldwide health problem as several millions of people are exposed to this toxicant. Arsenic contamination of different countries includes Bangladesh, India, Vietnam, Nepal, Thailand, and Chili is the major affected countries where inorganic arsenic in the groundwater with high concentration is seen. Arsenic is one of the most toxic metals which is originated from the natural environment. The catastrophe is that the majority of human arsenic toxicity is from polluted drinking water rather than agricultural sources (fertilizers or pesticides). The different areas across the Gangetic plains in Nepal and India also recently reported being affected by the arsenic. The hippocampus is a part of the limbic system that is crucial to memory function and spatial navigation. Hippocampus lesions in humans produce devastating impairments in declarative memory, and similar results have been seen in non-human primates with hippocampus neurobehavioral disorders.

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“…Its antioxidant mechanism includes free radicals scavenging of reactive nitrogen species and reactive oxygen species. Moreover, it inhibits lipid peroxidation by the inactivation of lipoxygenase, elevates reduced GSH level and superoxide dismutase (SOD) enzyme activity [5, 6].…”

Section: Introductionmentioning

confidence: 99%

L-Ascorbic Acid and Curcumin Prevents Brain Damage Induced via Lead Acetate in Rats: Possible Mechanisms

Alhusaini¹,

Fadda²,

Alsharafi³

et al. 2021

Dev Neurosci

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Lead acetate (lead ac.) is a widespread ecological toxicant that can cause marked neurotoxicity and decline in brain functions. This study aimed to evaluate the possible neuroprotective role of L-ascorbic (ASCR) and curcumin (CRCM) alone or together against lead ac.-induced neurotoxicity. Rats were injected with lead ac. then treated orally with ASCR and CRCM alone or in combination for seven days. Lead ac. caused elevation in brain tumor necrosis factor- α (TNF-α), interleukin-6 (IL-6), caspase-3, and malondialdehyde (MDA) levels, while superoxide dismutase (SOD), reduced glutathione (GSH) as well as the expression of brain-derived neurotrophic factor (BDNF), cAMP response element-binding (CREB) and Beclin1 were down-regulated. Expressions of C/EBP homologous protein (CHOP) and mammalian Target of rapamycin kinase (mTOR) were upregulated in brain tissues matched with the control group. Histopathological examination supported the previously mentioned parameters, the administration of the antioxidants in question modulated all the altered previous parameters. The combination regimen achieved the superlative results in the antagonizing lead ac.-induced neurotoxicity via its antioxidant and anti-apoptotic activities.

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CURCUMIN ATTENUATES LEAD (Pb)–INDUCED NEUROBEHAVIORL AND NEUROBIOCHEMICAL DYSFUNCTION: A REVIEW

Cited by 7 publications

References 43 publications

Protective Effect of Curcuma Longa Administration on Lung of Mice Exposed to Cadmium

Protective Effect of Curcuma Longa Administration on Lung of Mice Exposed to Cadmium

Arsenic: A Harmful and Desecrate Compound for the Humans

L-Ascorbic Acid and Curcumin Prevents Brain Damage Induced via Lead Acetate in Rats: Possible Mechanisms

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