Curcumin attenuates lipopolysaccharide/ d -galactosamine-induced acute liver injury by activating Nrf2 nuclear translocation and inhibiting NF-kB activation

Xie, Yilian; Chu, Jinguo; Jian, Xiao-Min; Dong, Jin-Zhong; Wang, Liping; Li, Guoxiang; Yang, Naibin

doi:10.1016/j.biopha.2017.04.070

Cited by 97 publications

(54 citation statements)

References 42 publications

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“…But its pathogenesis is not entirely clear (10). It has been confirmed that long-term alcohol intake can activate NF-κB in liver tissue, and the activated NF-κB enters into the nucleus, bond to the κB sequence in promoter regions of various inflammatory factors, to promote the transcriptions of inflammatory cytokines (TNF-1, IL-2, IL-6, etc.…”

Section: Introductionmentioning

confidence: 99%

Quercetin prevents alcohol‑induced liver injury through targeting of PI3K/Akt/nuclear factor‑κB and STAT3 signaling pathway

2017

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Abstract. Quercetin is a type of flavonoid compound, which has potent antioxidant and anti-inflammatory activities, capable of treating a variety of diseases including neurodegenerative diseases, tumors, diabetes and obesity. The present study selected alcohol-induced liver injury model mice and aimed at studying the protective role of quercetin in preventing alcohol-induced liver injury. In alcohol-induced liver injury mice treated with quercetin, it was demonstrated that levels of aspartate transaminase, alanine transaminase, total bilirubin and triglyceride were reduced. In addition to this, the activities of the antioxidant enzymes superoxide dismutase and glutathione peroxidase were increased, malondialdehyde was inhibited, and interleukin (IL)-1β, IL-6, IL-10 and inducible nitric oxide synthase were suppressed. Quercetin additionally suppressed the protein expression levels of B-cell lymphoma (Bcl)-2, Bcl-2 associated X apoptosis regulator, Caspase-3, poly ADP-ribose polymerase, and signal transducer and activator of transcription (STAT) 3 phosphorylation, nuclear factor (NF)-κB and protein kinase B (Akt) phosphorylation levels in alcohol-induced liver injured mice. These results suggested that the protective role of quercetin prevents alcohol-induced liver injury through the phosphoinositide 3-kinase/Akt/NF-κB and STAT3 pathway.

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Section: Introductionmentioning

confidence: 99%

Quercetin prevents alcohol‑induced liver injury through targeting of PI3K/Akt/nuclear factor‑κB and STAT3 signaling pathway

2017

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“…A previous study has demonstrated that myricitrin, by scavenging ROS and preventing lipid peroxidation, protects against vascular endothelial cell damage and inhibits early Atherosclerosis plaque formation (Sun et al, ). Xie et al () also reported that curcumin, a polyphenol isolated from the rhizome of turmeric, attenuates lipopolysaccharide/D‐galactosamine‐induced acute liver injury by activating Nrf2 nuclear translocation. In this present study, myricitrin (45.80 mg/g), i.e., 4.58% and curcumin (7.70 mg/g) i.e., 0.77% were identified as the main compounds in DLE and CLE, respectively (supplementary data Fig.…”

Section: Discussionmentioning

confidence: 99%

“…Cells overexpressing constitutively active Akt enhance Nrf2 activity that results in the increase of antioxidant proteins thus suggesting that the PI3K/Akt pathway is essential in regulating the Nrf2-antioxidant response element-dependent protection against oxidative stress (Wang, Chen, Sternberg, & Cai, 2008 (Sun et al, 2013). Xie et al (2017) also reported that curcumin, a polyphenol isolated from the rhizome of turmeric, attenuates lipopolysaccharide/D-galactosamine-induced acute liver injury by activating Nrf2 nuclear translocation. In this present study, myricitrin (45.80 mg/g), i.e., 4.58% and curcumin (7.70 mg/g) i.e., 0.77% were identified as the main compounds in DLE and CLE, respectively (supplementary data Fig.…”

Section: Discussionmentioning

confidence: 99%

Photoprotective properties of combined extracts fromDiospyros lotusleaves andCurcuma longarhizomes against chronic UVB‐induced photodamage

et al. 2018

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The synergistic effects of combined ethanolic extracts of Diospyros lotus leaves (DLE) and Curcuma longa rhizomes (CLE) were investigated for their protective effects on chronic Ultraviolet‐B (UVB)‐induced skin photodamage in SHK‐1 mice. The degree of protection was measured by using biochemical parameters such as malondialdehyde, reduced glutathione, superoxide dismutase, catalase, Akt activation, and nuclear factor (erythroid‐derived 2)‐like 2 (Nrf2) activities, collagen degradation among others. DLE, CLE, and DLE/CLE demonstrated significant photodamage protection by upregulating endogenous antioxidant in mice skin through the activation of Akt and Nrf2 activities; prevented epidermal hyperplasia; mast cell infiltration into the skin and collagen degradation. The effects of the combined extract were greater than the effects of the single extracts. Also, the synergistic effects of DLE/CLE were comparable to that of standard drug, ascorbic acid. This study suggests the synergistic protective role of DLE/CLE in the treatment UVB‐induced photodamage. Practical application The use of synthetic antioxidant products to prevent oxidative‐related stress, especially from UV radiations is frequently accompanied with severe side effects. Therefore, the search for natural antioxidants is of utmost importance. Polyphenols are of great interest due to their antioxidant properties and small molecular weight that permits them to penetrate the skin. Diospyros lotus (rich in myricitrin) and Curcuma longa rhizomes (rich in curcumin) are both edible plants. This research investigates the synergetic effects of extracts of both plants against chronic UVB‐induced oxidative stress. Data obtained from this study shed light on using plant‐based products both alone and in synergy as potential functional foods and nutraceuticals for the prevention of UVB‐induced oxidative stress. The results of this research could serve as a base for further research on these extracts as a source of antioxidant and promotes the usage of these plants on a large scale as functional food materials.

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“…The activation of toll receptor signaling pathways participates in the destruction of articular cartilage and synovial membrane process; TLR4 is a member of toll receptor family (21). It is mainly expressed in various immune cells.…”

Section: Discussionmentioning

confidence: 99%

Sparstolonin B prevents lumbar intervertebral disc degeneration through toll like receptor 4, NADPH oxidase activation and the protein kinase B signaling pathway

Chen

Yang

et al. 2017

Mol Med Report

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Intervertebral disc degeneration (IVDD) is the most common pathogeny of lumbago. It is the pathological basis for a series of spinal degenerative diseases. For a long time, the diagnosis and treatment of lumbago have rendered difficult, since the pathogeny has not been identified. Therefore, the present study aimed to investigate the protective effect of Sparstolonin B in preventing lumbar intervertebral disc degeneration, and explored its potential mechanism in rats. Firstly, Sparstolonin B effectively reduced the histological score of disc degeneration and increased endplate porosity of L2 superior endplates in a lumbar IVDD rat model. Sparstolonin B significantly inhibited the IVDD‑induced inflammatory factors tumor necrosis factor‑α, interleukin (IL)‑1β and IL‑6, oxidative stress factors (malondialdehyde), and superoxide dismutase and caspase‑3/9 activities. Treatment with Sparstolonin B significantly suppressed toll‑like receptor 4 (TLR4), myeloid differentiation primary response protein 88 (MyD88) and nuclear factor (NF)‑κB protein expression, inhibited NAPDH oxidase 2 protein expression and induced phosphoinositide 3‑kinase and phosphorylated protein kinase B protein expression in the IVDD rat model. These results demonstrated that Sparstolonin B prevents lumbar IVDD‑induced inflammation, oxidative stress and apoptosis through TLR4/MyD88/NF‑κB, NADPH oxidase activation and the phosphoinositide 3‑kinase/protein kinase B signaling pathway. These results implicate Sparstolonin B for use as a therapeutic agent for IVDD in clinical applications.

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Curcumin attenuates lipopolysaccharide/ d -galactosamine-induced acute liver injury by activating Nrf2 nuclear translocation and inhibiting NF-kB activation

Cited by 97 publications

References 42 publications

Quercetin prevents alcohol‑induced liver injury through targeting of PI3K/Akt/nuclear factor‑κB and STAT3 signaling pathway

Quercetin prevents alcohol‑induced liver injury through targeting of PI3K/Akt/nuclear factor‑κB and STAT3 signaling pathway

Photoprotective properties of combined extracts fromDiospyros lotusleaves andCurcuma longarhizomes against chronic UVB‐induced photodamage

Sparstolonin B prevents lumbar intervertebral disc degeneration through toll like receptor 4, NADPH oxidase activation and the protein kinase B signaling pathway

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