Curcumin attenuates myocardial ischemia-reperfusion injury

Liu, Kun; Chen, Hong‐Lin; You, Qingsheng; Ye, Qing; Wang, Fei; Wang, Shuo; Zhang, Shuanglong; Yu, Kang-Jun; Lu, Qi

doi:10.18632/oncotarget.23002

Cited by 27 publications

(35 citation statements)

References 17 publications

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“…Curcumin improved dyslipidemia and liver dysfunction in high fat high sucrose fed rats 15 . Curcumin has the ability to alleviate myocardial injury with inhibition of pro-inflammatory cytokine in rats with coronary artery ligated and in isolated heart 64 which was likely demonstrated in the present study. Modulation of post-translational modifications like protein acetylation is considered as one of the most recent strategy to combat cardiovascular disease; curcumin and DHA are emerging agents that possess this activity mediated through modulation of sirtuin 65 .…”

Section: Discussionsupporting

confidence: 73%

Role of Borage Seed Oil and Fish Oil with or without Turmeric and Alpha- Tocopherol in Prevention of Cardiovascular Disease and Fatty Liver in Rats

et al. 2018

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Introduction Cardiovascular diseases CVDs are considered as the major cause of morbidity and death worldwide in both developed and developing countries 1. Dyslipidemia, oxidative stress and inflammation are among the reported risk factors for cardiovascular diseases 2. Recently fatty liver with inflammation steatohepatitis , which is increasing worldwide, is accused as being major player in induction of cardiovascular diseases 3. Generally, the condition including dyslipidemia, inflammation, steatohepatitis, oxidative stress and impaired glucose tolerance is called metabolic syndrome.

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Section: Discussionsupporting

confidence: 73%

Role of Borage Seed Oil and Fish Oil with or without Turmeric and Alpha- Tocopherol in Prevention of Cardiovascular Disease and Fatty Liver in Rats

et al. 2018

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“…It has been reported that curcumin is a potent cardioprotective compound, which may have beneficial effects on MIRI by reducing oxidative stress, preventing inflammation and inhibiting cardiomyocyte apoptosis (16). Numerous studies have indicated that traditional Chinese medicine (TCM) exerts a potent cardioprotective effect on MIRI and may be used as a therapeutic approach for its treatment (17,18).…”

Section: Introductionmentioning

confidence: 99%

Combination of the ginsenosides Rb3 and Rb2 exerts protective effects against myocardial ischemia reperfusion injury in rats

Liu

Jiang

et al. 2019

Int J Mol Med

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Ginsenoside Rb3 (G-Rb3) has been demonstrated to alleviate myocardial ischemia reperfusion injury (MIRI); however, it is difficult to separate G-Rb2 from its isomer G-Rb3. The current study aimed to compare the cardioprotective effects of G-Rb3 and the concomitant use of G-Rb3 and G-Rb2 (G-Rb3/Rb2) on MIRI in rats. A rat model of MIRI was established by ligation of the left anterior descending coronary artery and the rats were randomly divided into five groups. Prior to MIRI, G-Rb3/Rb2 (20 mg/kg), G-Rb3 (20 mg/kg) and diltiazem (DLZ; 20 mg/kg, as a positive control) were orally administered to the rats once a day for 3 consecutive days. After 30 min of ischemia and 120 min of reperfusion, cardiac function, infarct size, cardiac marker enzymes, antioxidative parameters, inflammatory factors, histopathological changes, cardiomyocyte apoptosis, and B-cell lymphoma 2 (Bcl-2), Bcl-2-associated X protein and caspase-3 expression were determined using a multi-channel physiological recording system, nitrotetrazolium blue chloride, biochemical kits, radioimmunoassay kits, hematoxylin and eosin, terminal deoxynucleotidyl-transferase-mediated dUTP nick end labeling assay, immunohistochemistry and reverse transcription-quantitative PCR, respectively. The results indicated that treatment with G-Rb3/Rb2 significantly protected rats against MIRI, as shown by improved cardiac function, reduced myocardial ischemic area, decreased serum activities of aspartate aminotransferase, lactate dehydrogenase and creatine kinase MB, decreased serum concentrations of interleukin-6 and tumor necrosis factor-α, decreased malondialdehyde concentration in myocardial tissues, increased activities of superoxide dismutase, glutathione peroxidase and catalase in myocardial tissues, reduced histopathological changes in myocardial tissues, reduced number of apoptotic cardiomyocytes, and changes in the expression levels of caspase-3, Bcl-2 and Bax. In addition, the effects of treatment with G-Rb3/Rb2, G-Rb3 or DLZ were equivalent. The protective effects of G-Rb3/Rb2 on MIRI were similar to those of G-Rb3 in terms of oxidative stress, inflammatory factors and inhibition of cardiomyocyte apoptosis. Therefore, G-Rb3/Rb2 may be developed as a concomitant treatment for MIRI.

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“…At present, it is not known how simvastatin can protect the myocardium by reducing the expression of caspase-3 through anti-apoptosis. However, Liu et al (20) indicated that the expression of p53 and caspase-3 in simvastatin decreased significantly in the the simvastatin group with simvastatin preconditioning renal ischemia reperfusion, and the level of oxygen free radicals were also decreased (P<0.05). It is presumed that simvastatin may scavenge the excess oxygen free radicals induced by renal ischemia-reperfusion injury, and then decrease the oxidative damage effect of myocardial cells, reduce the expression of p53 and caspase-3, and ultimately inhibit cell apoptosis.…”

Section: Discussionmentioning

confidence: 97%

The effects of simvastatin preconditioning on the expression of caspase-3 after myocardial ischemia reperfusion injury in rats

et al. 2019

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Effect of simvastatin on the expression of caspase-3 in myocardial ischemia reperfusion injury in rats was observed to explore the protective effect of caspase-3 through anti-apoptosis mechanism. A total of 48 healthy male SD rats weighing 160–240 g were selected and divided into 4 groups randomly, namely, the blank group, the sham operation group, the ischemia-reperfusion group and the simvastatin group, with 12 rats in each group. The model of SD rats was made by ligation. The loosen ligature made the reperfusion animal model, the occurrence of arrhythmia in the electrocardiogram of lead II in the experimental animal model was observed, and the area of myocardial infarction in the experimental animal models was detected. The number of apoptotic cells was detected by immunohistochemistry, and the expression of caspase-3 was detected by western blotting. The infarct area in the simvastatin group was significantly lower than the ischemia reperfusion group (P<0.05). The positive rate of the expression of caspase-3 and the positive rate of the expression of apoptotic cells in the ischemic reperfusion and simvastatin groups were significantly higher than that of the blank and sham operation groups, and the positive rate of the expression of caspase-3 and apoptotic cells in the simvastatin group was significantly lower than that of the ischemia-reperfusion group (P<0.05). The arrhythmia score of the simvastatin group was significantly lower than that of the ischemia-reperfusion group (P<0.05). Compared with the blank and sham operation groups, the expression of caspase-3 protein in the ischemia-reperfusion and simvastatin groups was significantly increased, and the expression of caspase-3 protein in the simvastatin group was significantly lower than that of the ischemia reperfusion group (P<0.05). Simvastatin has a protective effect on myocardial ischemia-reperfusion injury, which may be related to the reduction of caspase-3 expression and inhibition of apoptosis.

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Curcumin attenuates myocardial ischemia-reperfusion injury

Cited by 27 publications

References 17 publications

Role of Borage Seed Oil and Fish Oil with or without Turmeric and Alpha- Tocopherol in Prevention of Cardiovascular Disease and Fatty Liver in Rats

Role of Borage Seed Oil and Fish Oil with or without Turmeric and Alpha- Tocopherol in Prevention of Cardiovascular Disease and Fatty Liver in Rats

Combination of the ginsenosides Rb3 and Rb2 exerts protective effects against myocardial ischemia reperfusion injury in rats

The effects of simvastatin preconditioning on the expression of caspase-3 after myocardial ischemia reperfusion injury in rats

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