Curcumin attenuates sepsis-induced acute organ dysfunction by preventing inflammation and enhancing the suppressive function of Tregs

Chen, Longwang; Lu, Yang; Zhao, Lingfei; Hu, Lin; Qiu, Qiao-meng; Zhang, Zhuoling; Li, Mengfang; Hong, Guangliang; Wu, Bing; Zhao, Guangju; Lu, Zhongqiu

doi:10.1016/j.intimp.2018.04.041

Cited by 56 publications

(64 citation statements)

References 38 publications

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“…As it is mentioned in a lot of studies, curcumin has the ability to modulate the activation and the proliferation of T cells (Ranjan, Chen, Johnston, Jeon, & Nagabhushan, ). Chen, Lu, et al () have shown that curcumin can upregulate the CD4 + CD25 + Foxp3 + Treg cells and increase the production of TGF‐β and IL‐10 that leads to downregulated proliferation activity of CD4 + CD25 − T cells in the spleen of the septic mice.…”

Section: Discussionmentioning

confidence: 99%

“…Reducing the antioxidant capacity (Rogobete et al, 2017) in these patients due to inefficient oxidative phosphorylation (Lorente et al, 2018) leads to an increase in free radicals (Oliveira, Pontes-de-Carvalho, Couto, & Noronha-Dutra, 2017), which is actually a possible mechanism for damage caused by the sepsis (Kumar et al, 2018). Some natural compounds and herbal derivatives have anti-inflammatory and antioxidant effects that can improve sepsis symptoms, such as zinc (Ganatra et al, 2017), magnesium (Esen et al, 2004), Q10 (Abitagaoglu et al, 2015), and curcumin (Chen, Lu, et al, 2018). Turmeric is a medicinal plant that belongs to the ginger species (Zingiberaceae), distributed throughout subtropical and tropical regions of the world, and broadly growing in Asian countries such as India and China (Yadav, Yadav, Khar, Mujeeb, & Akhtar, 2013).…”

mentioning

confidence: 99%

“…Recent evidences have shown that curcumin possesses multiple biological activities and pharmacological properties including anti-inflammation (Dhir, 2018), antioxidation (Khanji et al, 2018), anticancer and antiproliferation (Barati, Momtazi-Borojeni, Majeed, & Sahebkar, 2019;Pan, Chen, Baek, & Zhong, 2018), antimicrobial (Marini et al, 2018), and free radical scavenger (Vaughn et al, 2017;Zhong et al, 2016). Some studies have suggested protective effects of curcumin against numerous diseases such as metabolic syndrome (due to improving insulin sensitivity, suppressing adipogenesis, reducing elevated blood pressure and decrease inflammation) (Ghazimoradi et al, 2017), inflammatory bowel disease (inhibit nuclear factor kappa-light-chain-enhancer of activated B [NF-κB], 5-lipoxygenase, and Toll-like receptor 4 (TLR-4)) (Singla et al, 2014), rheumatoid arthritis (due to regulating immune response and decrease the expression of cytokines and chemokine, (such as monocyte chemoattractant protein1 (MCP-1)) (Khayyal et al, 2018), cardiovascular disease (due to adjustment of the enzyme related to the metabolism of lipoproteins, decrease inflammation, and oxidative stress) (Li et al, 2019), and sepsis (due to modulate immune responses) (Chen, Lu, et al, 2018). Furthermore, several studies have shown the role of curcumin in regulating immune response to infection, through targeting multiple molecular pathways, including NF-κB cell and activator protein 1 (AP-1) (Tabrizi et al, 2019) and activation of nuclear factor erythroid 2-related factor 2 (Nrf-2), which are respectively led to inhibiting inflammation and oxidative factor (Xie et al, 2017).…”

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confidence: 99%

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Therapeutic effects of curcumin on sepsis and mechanisms of action: A systematic review of preclinical studies

Karimi

Ghodsi

Kooshki

et al. 2019

Phytotherapy Research

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Sepsis is a complex disease that begins with an infectious disorder and causes excessive immune responses. Curcumin is considered as an active component of turmeric that can improve the condition in sepsis due to its anti‐inflammatory and antioxidant properties. PubMed, Embase, Google Scholar, Web of Science, and Scopus databases were searched. Searching was not limited to a specific publication period. Only English‐language original articles, which had examined the effect of curcumin on sepsis, were included. At first, 1,098 articles were totally found, and 209 articles were selected after excluding duplicated data; 46 articles were remained due to the curcumin effects on sepsis. These included 23 in vitro studies and 23 animal studies. Our results showed that curcumin and various analogs of curcumin can have an inhibitory effect on sepsis‐induced complications. Curcumin has the ability to inhibit the inflammatory, oxidative coagulation factors, and regulation of immune responses in sepsis. Despite the promising evidence of the therapeutic effects of curcumin on the sepsis complication, further studies seem necessary to investigate its effect and possible mechanisms of action in human studies.

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Section: Discussionmentioning

confidence: 99%

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confidence: 99%

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confidence: 99%

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Therapeutic effects of curcumin on sepsis and mechanisms of action: A systematic review of preclinical studies

Karimi

Ghodsi

Kooshki

et al. 2019

Phytotherapy Research

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“…In contrast to its negative effect on pro-inflammatory molecules, curcumin has been shown to regulate anti-inflammatory cytokines positively, in particular IL-10 (Larmonier et al, 2008;Chen et al, 2018;Mollazadeh et al, 2019;Chai et al, 2020). The latter is an essential negative regulator for inflammatory responses and is secreted by the dendritic cells that bind to DAMP released from damaged cells during aseptic or antigenic inflammatory reactions.…”

Section: Regulation Of Anti-inflammatory Cytokinesmentioning

confidence: 99%

The Inhibitory Effect of Curcumin on Virus-Induced Cytokine Storm and Its Potential Use in the Associated Severe Pneumonia

Liu

Ying

2020

Front. Cell Dev. Biol.

126

120

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Coronavirus infection, including SARS-CoV, MERS-CoV, and SARS-CoV2, causes daunting diseases that can be fatal because of lung failure and systemic cytokine storm. The development of coronavirus-evoked pneumonia is associated with excessive inflammatory responses in the lung, known as "cytokine storms," which results in pulmonary edema, atelectasis, and acute lung injury (ALI) or fatal acute respiratory distress syndrome (ARDS). No drugs are available to suppress overly immune responsemediated lung injury effectively. In light of the low toxicity and its antioxidant, antiinflammatory, and antiviral activity, it is plausible to speculate that curcumin could be used as a therapeutic drug for viral pneumonia and ALI/ARDS. Therefore, in this review, we summarize the mounting evidence obtained from preclinical studies using animal models of lethal pneumonia where curcumin exerts protective effects by regulating the expression of both pro-and anti-inflammatory factors such as IL-6, IL-8, IL-10, and COX-2, promoting the apoptosis of PMN cells, and scavenging the reactive oxygen species (ROS), which exacerbates the inflammatory response. These studies provide a rationale that curcumin can be used as a therapeutic agent against pneumonia and ALI/ARDS in humans resulting from coronaviral infection.

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“…improves the survival of mice with bacterial sepsis by reducing serum IL-1b levels and attenuating the infiltration of inflammatory cells . Curcumin, which is obtained from the rhizome of Curcuma longa, alleviates sepsis-induced acute organ injury by preventing inflammation and enhancing the suppressive function of T regulatory cells (Chen et al, 2018). Our previous studies showed that micheliolide, isolated from Michelia compressa (Magnoliaceae), can help maintain immune equilibrium and decrease PGN, S. aureus, and MRSA-triggered inflammatory response (Jiang et al, 2017).…”

Section: Introductionmentioning

confidence: 99%

Xuebijing Injection Alleviates Pam3CSK4-Induced Inflammatory Response and Protects Mice From Sepsis Caused by Methicillin-Resistant Staphylococcus aureus

Qian

Miao

et al. 2020

Front. Pharmacol.

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A leading cause of death worldwide is sepsis that develops as a dysregulated immune response to infection. Serious infection caused by methicillin-resistant Staphylococcus aureus (MRSA) increases the difficulty of treatment in septic patients. Host-directed therapy (HDT) is an emerging approach to bacterial infections. Xuebijing injection (XBJ), a commercialized injectable prescription from traditional Chinese medicine, has been used as adjuvant therapy for sepsis with a history of 15 years. Whether it plays a protective role in severe infection caused by antibiotic-resistant bacteria is still unknown. In this study, XBJ significantly improved the survival of MRSA-induced sepsis mice. In MRSA-infected mouse model, XBJ down-regulated the expression of inflammatory cytokines interleukin (IL)-6, tumor necrosis factor (TNF)-a, MCP-1, MIP-2, and IL-10 in sera. Besides that, it decreased the bacterial load in spleens, livers, and alleviated tissue damage of lung, liver, and kidney. The combination of XBJ with vancomycin or dexamethasone exhibited a better down-regulatory role of the inflammatory response. Then, the protective mechanism of XBJ was further investigated. XBJ inhibited heatkilled MRSA-induced IL-6 and TNF-a production in mouse macrophages. XBJ also decreased Pam3CSK4 (a synthetic tripalmitoylated lipopeptide mimicking bacterial lipoproteins)stimulated expression of IL-6, TNF-a, IL-1b, IL-12, etc. in mouse macrophages. Furthermore, XBJ down-regulated the activation of NF-kB, MAPK, and PI3K/Akt pathways in Pam3CSK4-stimulated mouse macrophages. In conclusion, our findings demonstrated that XBJ played a protective role in MRSA-challenged mice and down-regulated the inflammatory response and the activation of signaling pathways initiated by Pam3CSK4. It enlarged the clinical application of XBJ in the treatment of severe bacterial infection, e.g. caused by MRSA.

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Curcumin attenuates sepsis-induced acute organ dysfunction by preventing inflammation and enhancing the suppressive function of Tregs

Cited by 56 publications

References 38 publications

Therapeutic effects of curcumin on sepsis and mechanisms of action: A systematic review of preclinical studies

Therapeutic effects of curcumin on sepsis and mechanisms of action: A systematic review of preclinical studies

The Inhibitory Effect of Curcumin on Virus-Induced Cytokine Storm and Its Potential Use in the Associated Severe Pneumonia

Xuebijing Injection Alleviates Pam3CSK4-Induced Inflammatory Response and Protects Mice From Sepsis Caused by Methicillin-Resistant Staphylococcus aureus

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