Curcumin attenuates severity of premenstrual syndrome symptoms: A randomized, double-blind, placebo-controlled trial

Khayat, Samira; Fanaei, Hamed; Kheirkhah, Masoomeh; Moghadam, Zahra Behboodi; Kasaeian, Amir; Javadimehr, Mani

doi:10.1016/j.ctim.2015.04.001

Cited by 48 publications

(48 citation statements)

References 38 publications

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“…Curcumin with its intrinsic antioxidant properties could limit the toxic effects associated with arsenic (Biswas et al , ). It also inhibits exercise‐induced oxidative stress in humans and reduces the severity of premenstrual syndrome in women by modulating the levels of neurotransmitters and anti‐inflammatory biomolecules (Takahashi et al , ; Khayat et al , ). Administration of curcuminoids to β‐thalassemia/Hb E patients reduces oxidative damage (Kalpravidh et al , ).…”

Section: Clinical Studies With Curcuminmentioning

confidence: 99%

Curcumin, the golden nutraceutical: multitargeting for multiple chronic diseases

Kunnumakkara

Bordoloi

Padmavathi

et al. 2016

British J Pharmacology

855

601

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Section: Clinical Studies With Curcuminmentioning

confidence: 99%

Curcumin, the golden nutraceutical: multitargeting for multiple chronic diseases

Kunnumakkara

Bordoloi

Padmavathi

et al. 2016

British J Pharmacology

855

601

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“…In obese people, curcumin showed immunomodulatory and regulatory effects on serum concentrations of interleukin (IL)10, vascular endothelial growth factor, and IL‐1β (Ganjali et al, ). Curcumin has beneficial effects on Alzheimer's disease (Mishra & Palanivelu, ; Ringman, Frautschy, Cole, Masterman, & Cummings, ) and it was effective in treatment of major depressive disorder (Al‐Karawi, Al Mamoori, & Tayyar, ; Ng, Koh, Chan, & CYX, ) and has an effective role in reducing the symptoms of premenstrual syndrome (Khayat et al, ). Moreover, in obese people, curcumin showed antianxiety activity (Lao et al, ; Esmaily et al, ; Figure ).…”

Section: Introductionmentioning

confidence: 99%

Turmeric (Curcuma longa) and its major constituent (curcumin) as nontoxic and safe substances: Review

Soleimani

Sahebkar

Hosseinzadeh

2018

Phytotherapy Research

443

274

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Curcumin is the major constituent of turmeric (Curcuma longa). Turmeric has been widely used as a spice in foods and for therapeutic applications such as anti-inflammatory, antihyperlipidemic, and antimicrobial activities. Turmeric and curcumin are nonmutagenic and nongenotoxic. Oral use of turmeric and curcumin did not have reproductive toxicity in animals at certain doses. Studies on human did not show toxic effects, and curcumin was safe at the dose of 6 g/day orally for 4-7 weeks. However, some adverse effects such as gastrointestinal upsets may occur. Moreover, oral bioavailable formulations of curcumin were safe for human at the dose of 500 mg two times in a day for 30 days, but there are still few trials and more studies are needed specially on nanoformulations and it should be discussed in a separate article. In addition, curcumin is known as a generally recognized as safe substance. This review discusses the safety and toxicity of turmeric and curcumin in medicine. Turmeric and curcumin are nontoxic for human especially in oral administration. Turmeric and curcumin are also safe in animals. They are nonmutagenic and are safe in pregnancy in animals but more studies in human are needed.

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“…Furthermore, significant differences between mean changes were recorded. These results showed for the first time a potential advantage of curcumin supplementation on reducing PMS symptoms, possibly mediated via the modulation of neurotransmitters and the anti‐inflammatory effects of curcumin (Khayat et al, ).…”

Section: Curcumin and Premenstrual Syndrome Symptomsmentioning

confidence: 88%

“…A recent double‐blinded study evaluated the effects of curcumin on the severity of premenstrual syndrome symptoms (Khayat et al, ). In fact, 70 women suffering from premenstrual syndrome symptoms were randomly allocated to placebo and curcumin groups.…”

Section: Curcumin and Premenstrual Syndrome Symptomsmentioning

confidence: 99%

Effects of curcumin consumption on human chronic diseases: A narrative review of the most recent clinical data

Mantzorou

Pavlidou

Vasios

et al. 2018

Phytotherapy Research

114

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Numerous clinical trials have investigated the potential beneficial effects of curcumin supplementation against several human chronic diseases. Up to now, it has been claimed that curcumin consumption may exert beneficial effects against several chronic diseases by promoting human health and preventing diseases. In this aspect, the present review aims to critically collect and in-depth summarize the most recent, well-designed clinical studies evaluating the potential beneficial effects of curcumin consumption on human health promotion and disease prevention. According to recent and well-designed clinical studies, curcumin consumption may benefit against obesity, metabolic syndrome, and diabetes. Moreover, curcumin consumption seems to exert a positive effect on people suffering from various types of cancer, fatty liver disease, depression, arthritis, skin diseases, gut inflammation, and symptoms of premenstrual syndrome. Due to the strong heterogeneity among the clinical studies concerning the exact effective curcumin dose and formulation, as well as the recommended treatment duration for each chronic disease, no precise and definitive conclusions could be drawn. Further large-scale prospective studies are strongly recommended, being well-designed as far as follow-up times, dosage, formulation, and duration of curcumin supplementation are concerned. Moreover, potential confounders in each specific chronic disease should carefully be taken into account in future studies.

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Curcumin attenuates severity of premenstrual syndrome symptoms: A randomized, double-blind, placebo-controlled trial

Cited by 48 publications

References 38 publications

Curcumin, the golden nutraceutical: multitargeting for multiple chronic diseases

Curcumin, the golden nutraceutical: multitargeting for multiple chronic diseases

Turmeric (Curcuma longa) and its major constituent (curcumin) as nontoxic and safe substances: Review

Effects of curcumin consumption on human chronic diseases: A narrative review of the most recent clinical data

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