Curcumin Attenuates Staurosporine-Mediated Death of Retinal Ganglion Cells

Abstract

The results show that curcumin attenuates RGC and amacrine cell death despite elevated levels of proteases and raises the possibility that it may be used as a plausible adjuvant therapeutic agent to prevent the loss of these cells in retinal degenerative conditions.

Curcumin protects against staurosporine toxicity in rat neurons

“…Recently, it was reported that curcumin protects against STS-induced cell death in retinal ganglion cells, possibly by regulating NFκB [16] . Here, we showed that ROS, Csp3, Hsp70…”

Thermosensitive in situ nanogel as ophthalmic delivery system of curcumin: development, characterization, in vitro permeation and in vivo pharmacokinetic studies

“…CUR has also been proved effective for ophthalmic use in various ocular fundus pathologies. It inhibits proliferation of human lens epithelial cells and protects retinal cells, retinal ganglion cells and corneal epithelial cells 18,19 . However, owing to main drawbacks such as low solubility, instability, poor bioavailability, the clinical application of CUR is limited.…”

Curcumin Delays Retinal Degeneration by Regulating Microglia Activation in the Retina of rd1 Mice

“…Although the drug-delivery of curcumin is mostly gavage [25], oral [60], or by intraperitoneal injection [61], and rarely by intravitreal injection [31], we chose intravitreal injection to achieve the effective local concentration rapidly. In addition, intravitreal injection can be used to distinguish between the treated and untreated eye of a mouse [62-66].…”

“…Mice at P7 were anesthetized by intraperitoneal injection of 1% pelltobarbitalum natricum (10 µL). After a drop of topical anesthetic agent (oxybuprocaine) was administered, DMSO or curcumin (10 µM/L dissolved in DMSO) [31] was injected into the vitreous humor with a syringe (33G; Hamilton, Bonaduz, Switzerland). Unless otherwise indicated, intravitreal injections were performed in a final volume of 1 µL [30, 32].…”