Curcumin based nanomedicines as efficient nanoplatform for treatment of cancer: New developments in reversing cancer drug resistance, rapid internalization, and improved anticancer efficacy

Khan, Shahzeb; Imran, Muhammad; Butt, Tariq Tahir; Shah, Syed Wadood Ali; Sohail, Muhammad; Malik, Arif; Das, Srijit; Thu, Hnin Ei; Adam, Aishah; Hussain, Zahid

doi:10.1016/j.tifs.2018.07.026

Cited by 76 publications

(33 citation statements)

References 135 publications

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“…It has the ability to regulate multiple signaling pathways, including cell cycle via down-regulation of cyclin D1, CDk4, and p53; Wnt signaling by up-regulating GSK3b and down-regulating E-cadherin, β-catenin, and c-MYC, restricting angiogenesis (NF-KB, AP-1, iNOS, NO, 5-LOX , COX-2 , MMP s), up-regulating miR-15 and miR-16 and promotes genomic stability via down-regulation of DNA methyl transferase 1 and histone protein alteration [ 15 , 16 ]. Notwithstanding its anti-cancer properties, clinical trial and pharmacokinetic data on curcumin displayed poor absorption and bio distribution, low bioavailability [ 17 , 18 , 19 ], inadequate biological stability [ 20 ], poor aqueous solubility [ 20 , 21 ], rapid metabolism [ 22 ], and rapid systemic elimination [ 19 , 23 ]. Curcumin which is hydrophobic [ 20 ] undergone biotransformation into curcumin glucuronides in the intestine and liver [ 24 , 25 ], which it is rapidly metabolized [ 22 ] and eliminate via feces [ 20 , 23 , 26 ].…”

Section: Introductionmentioning

confidence: 99%

The Curcumin Analogue, MS13 (1,5-Bis(4-hydroxy-3- methoxyphenyl)-1,4-pentadiene-3-one), Inhibits Cell Proliferation and Induces Apoptosis in Primary and Metastatic Human Colon Cancer Cells

et al. 2020

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The cytotoxic and apoptotic effects of turmeric (Curcuma longa) on colon cancer have been well documented but specific structural modifications of curcumin have been shown to possess greater growth-suppressive potential on colon cancer than curcumin. Therefore, the aim of this study is to identify the anti-cancer properties of curcumin analogue-MS13, a diarylpentanoid on the cytotoxicity, anti-proliferative and apoptotic activity of primary (SW480) and metastatic (SW620) human colon cancer cells. A cell viability assay showed that MS13 has greater cytotoxicity effect on SW480 (EC50: 7.5 ± 2.8 µM) and SW620 (EC50: 5.7 ± 2.4 µM) compared to curcumin (SW480, EC50: 30.6 ± 1.4 µM) and SW620, EC50: 26.8 ± 2.1 µM). Treatment with MS13 at two different doses 1X EC50 and 2X EC50 suppressed the colon cancer cells growth with lower cytotoxicity against normal cells. A greater anti-proliferative effect was also observed in MS13 treated colon cancer cells compared to curcumin at 48 and 72 h. Subsequent analysis on the induction of apoptosis showed that MS13 treated cells exhibited morphological features associated with apoptosis. The findings are also consistent with cellular apoptotic activities shown by increased caspase-3 activity and decreased Bcl-2 protein level in both colon cancer cell lines. In conclusion, MS13 able to suppress colon cancer cell growth by inhibiting cell proliferation and induce apoptosis in primary and metastatic human colon cancer cells.

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Section: Introductionmentioning

confidence: 99%

The Curcumin Analogue, MS13 (1,5-Bis(4-hydroxy-3- methoxyphenyl)-1,4-pentadiene-3-one), Inhibits Cell Proliferation and Induces Apoptosis in Primary and Metastatic Human Colon Cancer Cells

et al. 2020

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“…Nanocarriers have been used for curcumin delivery to circumvent the substance’s bioavailability, which greatly limits its use for therapeutic ends in patients [ 84 , 85 ]. Types include nanoparticles (NPs), liposomes, or ultrasound microbubbles [ 86 , 87 ]. Additionally, biopolymers can also be used as nanocarriers, which include chitosan, starch, zein, alginate, and silk, among others.…”

Section: Curcumin-loaded Colloidal Delivery Systemsmentioning

confidence: 99%

Properties, Extraction Methods, and Delivery Systems for Curcumin as a Natural Source of Beneficial Health Effects

et al. 2020

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This review discusses the impact of curcumin—an aromatic phytoextract from the turmeric (Curcuma longa) rhizome—as an effective therapeutic agent. Despite all of the beneficial health properties ensured by curcumin application, its pharmacological efficacy is compromised in vivo due to poor aqueous solubility, high metabolism, and rapid excretion that may result in poor systemic bioavailability. To overcome these problems, novel nanosystems have been proposed to enhance its bioavailability and bioactivity by reducing the particle size, the modification of surfaces, and the encapsulation efficiency of curcumin with different nanocarriers. The solutions based on nanotechnology can improve the perspective for medical patients with serious illnesses. In this review, we discuss commonly used curcumin-loaded bio-based nanoparticles that should be implemented for overcoming the innate constraints of this natural ingredient. Furthermore, the associated challenges regarding the potential applications in combination therapies are discussed as well.

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“…Curcumin (Cur), a natural phenolic compound from the rhizome of turmeric, has been attracting increasing attention due to its ability to regulate multiple cell signaling pathways,1 as well as for its anti-inflammatory,2 anti-microbial,3 anti-oxidant,4 wound-healing,5,6 hypoglycemic,7 bone regenerative,8 and anti-cancer properties 9,10. It is generally recognized as safe by the US Food and Drug Administration (FDA) 11.…”

Section: Introductionmentioning

confidence: 99%

<p>Elaboration and characterization of curcumin-loaded Tri-CL-mPEG three-arm copolymeric nanoparticles by a microchannel technology</p>

Wu¹,

Wu²,

Fu³

et al. 2019

IJN

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Purpose: Clinical applications of curcumin (Cur) have been greatly restricted due to its low solubility and poor systemic bioavailability. Three-arm amphiphilic copolymer tricarballylic acid-poly (ε-caprolactone)-methoxypolyethylene glycol (Tri-CL-mPEG) nanoparticles (NPs) were designed to improve the solubility and bioavailability of Cur. The present study adopted a microchannel system to precisely control the preparation of self-assembly polymeric NPs via liquid flow-focusing and gas displacing method. Methods: The amphiphilic three-arm copolymer Tri-CL-mPEG was synthesized and self-assembled into nearly spherical NPs, yielding Cur encapsulated into NP cores (Cur-NPs). The obtained NPs were evaluated for physicochemical properties, morphology, toxicity, cellular uptake by A549 cells, release in vitro, biodistribution, and pharmacokinetics in vivo. Results: Rapidly fabricated and isodispersed Cur-NPs prepared by this method had an average diameter of 116±3 nm and a polydispersity index of 0.197±0.008. The drug loading capacity and entrapment efficiency of Cur-NPs were 5.58±0.23% and 91.42±0.39%, respectively. In vitro release experiments showed sustained release of Cur, with cumulative release values of 40.1% and 66.1% at pH 7.4 and pH 5.0, respectively, after 10 days post-incubation. The results of cellular uptake, biodistribution, and in vivo pharmacokinetics experiments demonstrated that Cur-NPs exhibited better biocompatibility and bioavailability, while additionally enabling greater cellular uptake and prolonged circulation with possible spleen, lung, and kidney targeting effects when compared to the properties of free Cur. Conclusion: These results indicate that Tri-CL-mPEG NPs are promising in clinical applications as a controllable delivery system for hydrophobic drugs.

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Curcumin based nanomedicines as efficient nanoplatform for treatment of cancer: New developments in reversing cancer drug resistance, rapid internalization, and improved anticancer efficacy

Cited by 76 publications

References 135 publications

The Curcumin Analogue, MS13 (1,5-Bis(4-hydroxy-3- methoxyphenyl)-1,4-pentadiene-3-one), Inhibits Cell Proliferation and Induces Apoptosis in Primary and Metastatic Human Colon Cancer Cells

The Curcumin Analogue, MS13 (1,5-Bis(4-hydroxy-3- methoxyphenyl)-1,4-pentadiene-3-one), Inhibits Cell Proliferation and Induces Apoptosis in Primary and Metastatic Human Colon Cancer Cells

Properties, Extraction Methods, and Delivery Systems for Curcumin as a Natural Source of Beneficial Health Effects

<p>Elaboration and characterization of curcumin-loaded Tri-CL-mPEG three-arm copolymeric nanoparticles by a microchannel technology</p>

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