Curcumin copolymerized drugs mediated by enteric-coated polymers: Their design, synthesis and biocompatibility cell imaging studies

Liu, Ying; Lian, Guangchang; Wang, Zhenning; Hu, Kaibo; Zhou, Meng; Dou, Yuchen; Li, Siling; Chen, En; Jin, Guofan

doi:10.1016/j.eurpolymj.2022.111606

Cited by 12 publications

(2 citation statements)

References 19 publications

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“…The important characteristic and active components extracted from the traditional chinese medicine turmeric have good application prospects and clinical therapeutic potential in the diversity of pharmacological actions ( Kocaadam and Sanlier 2017 ; Hosseini and Hosseinzadeh 2018 ; Hay et al, 2019 ; Liu et al, 2022a ). In a number of studies involving cancer and tumor cells, it was found that curcumin may play a good inhibitory role in a variety of different links ( Mortezaee et al, 2019 ; Zendehdel et al, 2019 ), it effectively inhibits the uncontrolled metastasis of cancer cells ( Jia et al, 2019 ), the proliferation of tumor cells, the activity of cancer-inducing chemicals in the stomach and colon ( Porras et al, 2020 ; Naji et al, 2021 ), and inhibits angiogenesis by modulating protease activity ( Binion et al, 2008 ; Liu et al, 2022b ; Hu et al, 2022 ).…”

Section: Introductionmentioning

confidence: 99%

Application study of curcumin fluorescent complex coated with pharmaceutical excipients for cell imaging

et al. 2023

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Taking curcumin as the starting point, β-cyclodextrin was introduced on both sides, and lipid-soluble curcumin was coated by acrylic resin using oil-in-water strategy. Four different types of curcumin fluorescent complexes EPO-Curcumin (EPO-Cur), L100-55-Curcumin (L100-55-Cur), EPO -Curcumin-β-cyclodextrin (EPO-Cur-β-cd) and L100-55-Curcumin-β-cyclodextrin (L100-55-Cur-β-cd) were prepared to solve their own solubility and biocompatibility issues. The prepared curcumin fluorescent complexes were characterized and tested by spectroscopy. The characteristic peaks of 3446 cm−1 (hydroxyl group), 1735cm−1(carbonyl group) and 1455 cm−1 (aromatic group) were determined in the infrared spectrum. In the fluorescence emission spectrum, it was found that the emission intensity of different curcumin fluorescent complexes in polar solvents reached hundreds of times. Through the transmission electron microscopy shows that acrylic resin tightly coats curcumin into rods or clusters. In order to observe their compatibility with tumor cells more directly, live cell fluorescence imaging was carried out, and it was found that all four kinds of curcumin fluorescence complexes had good biocompatibility. In particular, the effect of EPO-Cur-β-cd and L100-55-Cur-β-cd is better than that of EPO-Cur and L100-55-Cur.

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Section: Introductionmentioning

confidence: 99%

Application study of curcumin fluorescent complex coated with pharmaceutical excipients for cell imaging

et al. 2023

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“…Drugs with limited solubility may become more soluble by coating technology, improving their relative bioavailability in the body and allowing for improved absorption. Additionally, acrylic resin has the benefit of having less hazardous side effects and minimizing bodily harm ( Liu et al, 2022b ; Ying et al, 2022 ).…”

Section: Introductionmentioning

confidence: 99%

A porous form Coomassie brilliant blue G250-isorhamnetin fluorescent composite coated with acrylic resin for tumor cell imaging

Hu,

Teng,

et al. 2023

Front. Chem.

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Four distinct fluorescence complexes, the fluorescent complex-1 (FC-1), fluorescent complex-2 (FC-2), fluorescent complex third (FC-3) and fluorescent complex fourth (FC-4), were created using isorhamnetin and Coomassie brilliant blue G250 as raw materials. The issue of isorhamnetin’s low solubility has been resolved, and isorhamnetin-coomassie brilliant blue G250 now has better biocompatibility. Four different forms of fluorescence compounds’ ultraviolet absorption spectra were identified. It was discovered that FC-2, FC-3, and FC-4, respectively, had double peaks at 483–620 nm. FC-4 had the highest ultraviolet absorption intensity, whereas FC-1 exhibited the most consistent and longest wavelength of ultraviolet absorption. Transmission electron microscopy revealed that the acrylic resin evenly disseminated the Coomassie brilliant blue G250-isorhamnetin complex in an amorphous flocculent form. Human prostate cancer cells (PC3) and human cervical cancer cells (HeLa) were investigated in the (Cell Counting Kit-8) CCK8 experiment under 10 different concentration circumstances, and the proliferation impact was 64.30% and 68.06%, respectively. Shown the complex’s strong anti-tumor properties and minimal cytotoxicity. Through in vitro imaging of tumor cells, it was found that FC-1’s fluorescent complex has high selectivity and can accurately infiltrate tumor cells, proving that it is biocompatible. The design not only addresses the issue of isorhamnein-Coomassie Bright Blue G250’s bioavailability, but it also has an effective visual fluorescence targeting effect.

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Blue Emission of Tetrafluorobenzocarbazole Under the Interactions of Nitrogen–oxygen Saturated hydrogen Bonds with Aggregated Proton Acid

Lian

Zhou

et al. 2022

J Fluoresc

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Curcumin copolymerized drugs mediated by enteric-coated polymers: Their design, synthesis and biocompatibility cell imaging studies

Cited by 12 publications

References 19 publications

Application study of curcumin fluorescent complex coated with pharmaceutical excipients for cell imaging

Application study of curcumin fluorescent complex coated with pharmaceutical excipients for cell imaging

A porous form Coomassie brilliant blue G250-isorhamnetin fluorescent composite coated with acrylic resin for tumor cell imaging

Blue Emission of Tetrafluorobenzocarbazole Under the Interactions of Nitrogen–oxygen Saturated hydrogen Bonds with Aggregated Proton Acid

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