Curcumin decreases oxidative stress in mitochondria isolated from liver and kidneys of high-fat diet-induced obese mice

Martínez-Morúa, Antonia; Soto-Urquieta, María G; Franco‐Robles, Elena; Zúñiga-Trujillo, Ismael; Campos-Cervantes, Alejandra; Pérez-Vázquez, Victoriano; Ramı́rez-Emiliano, Joel

doi:10.1080/10286020.2013.802687

Cited by 48 publications

(40 citation statements)

References 22 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The mitochondria are the main target for many anticancer agents. CMN and QR have been shown to protect the mitochondria against various oxidative stress conditions (Karuppagounder et al 2013;Martínez-Morúa et al 2013). Our study was designed to enlarge the therapeutic window of CMN and QR to regulate the neurotoxic effects of Oxa exposure in isolated brain mitochondria of rat.…”

Section: Introductionmentioning

confidence: 98%

Neuroprotective activities of curcumin and quercetin with potential relevance to mitochondrial dysfunction induced by oxaliplatin

Waseem

Parvez

2015

Protoplasma

View full text Add to dashboard Cite

Peripheral neurotoxicity is one of the serious dose-limiting side effects of oxaliplatin (Oxa) when used in the treatment of malignant conditions. It is documented that it elicits major side effects specifically neurotoxicity due to oxidative stress forcing the patients to limit its clinical use in long-term treatment. Oxidative stress has been proven to be involved in Oxa-induced toxicity including neurotoxicity. The mitochondria have recently emerged as targets for anticancer drugs in various kinds of toxicity including neurotoxicity that can lead to neoplastic disease. However, there is paucity of literature involving the role of the mitochondria in mediating Oxa-induced neurotoxicity and its underlying mechanism is still debatable. The purpose of this study was to investigate the dose-dependent damage caused by Oxa on isolated brain mitochondria under in vitro conditions. The study was also designed to investigate the neuroprotective effects of nutraceuticals, curcumin (CMN), and quercetin (QR) on Oxa-induced mitochondrial oxidative stress and respiratory chain complexes in the brain of rats. Oxidative stress biomarkers, levels of nonenzymatic antioxidants, activities of enzymatic antioxidants, and mitochondrial complexes were evaluated against the neurotoxicity induced by Oxa. Pretreatment with CMN and QR significantly replenished the mitochondrial lipid peroxidation levels and protein carbonyl content induced by Oxa. CMN and QR ameliorated altered nonenzymatic and enzymatic antioxidants and complex enzymes of mitochondria. We conclude that CMN and QR, by attenuating oxidative stress as evident by mitochondrial dysfunction, hold promise as agents that can potentially reduce Oxa-induced adverse effects in the brain.

show abstract

Section: Introductionmentioning

confidence: 98%

Neuroprotective activities of curcumin and quercetin with potential relevance to mitochondrial dysfunction induced by oxaliplatin

Waseem

Parvez

2015

Protoplasma

View full text Add to dashboard Cite

show abstract

“…However, upon investigating the effect of curcumin treatment on oxidative stress and mitochondrial dys- function in HFD-induced obese mice, Martínez-Morúa et al (2013) have found no significant elevation in the liver mitochondrial respiration chain and nitric oxide synthesis rates. In our study, the hepatic mitochondrial pro-oxidant-antioxidant system was also not influenced by HFD, which may be related to unaffected mitochondrial respiration rate.…”

mentioning

confidence: 95%

“…In animal models, curcumin supplementation, which exerts antioxidative and antilipidemic effects, has been suggested as an alternative treatment against lipid accumulation and oxidative damage, as well as mitochondrial dysfunction in fatty liver (Ejaz et al 2009;Martínez-Morúa et al 2013). In our previous study, high dose curcumin supplementation (400 mg·(kg body mass) -1 ·day -1 for 8 weeks) to rats by means of gavage, has been found to decrease hepatic lipids in the HFD group (Oner-İyidog an et al 2013).…”

mentioning

confidence: 99%

Effect of curcumin on hepatic heme oxygenase 1 expression in high fat diet fed rats: is there a triangular relationship?

Öner-İyidoğan

Tanrıkulu-Küçük

Seyithanoğlu

et al. 2014

Can. J. Physiol. Pharmacol.

View full text Add to dashboard Cite

High fat diet (HFD) is associated with oxidative stress induced fatty liver. Curcumin, an extract of Curcuma longa, has been shown to possess potent antioxidant and hypolipidemic properties. In this study, we investigated the effect of curcumin treatment on hepatic heme oxygenase-1 (HO-1) expression along with pro-oxidant-antioxidant status and lipid accumulation in rats fed an HFD. Male Sprague-Dawley rats were distributed among 4 groups: Group 1, which was fed the control diet (10% of total calories from fat); Group 2, which was fed the HFD (60% of total calories from fat); and groups 3 and 4, which received the HFD supplemented with curcumin and the control diet supplemented with curcumin (1 g/kg diet; w/w), respectively, for 16 weeks. HFD caused increases in hepatic lipid levels, production of reactive oxygen species, and lipid peroxidation. Further, HO-1 expression was significantly decreased. Histopathological examination showed hepatic fat accumulation and slight fibrotic changes. Curcumin treatment reduced hepatic lipids and oxidative stress parameters, and HO-1 expression was significantly increased. These findings suggest that increased HO-1 expression, along with suppressed oxidative stress as well as reduced hepatic fat accumulation and fibrotic changes, contribute to the beneficial effects of curcumin in attenuating the pathogenesis of fatty liver induced metabolic diseases.

show abstract

“…As an alternative, a number of studies have demonstrated the protective effect of curcumin towards mitochondrial dysfunction and mitochondrial oxidative stress (Zhu, Chen et al 2004, Martinez-Morua, Soto-Urquieta et al 2013). Most research has been concentrated on neurodegenerative diseases and finding new therapeutics for Alzheimer’s (Zhang, Fiala et al 2006, Mishra and Palanivelu 2008).…”

Section: Discussionmentioning

confidence: 99%

Controlled curcumin release via conjugation into PBAE nanogels enhances mitochondrial protection against oxidative stress

Gupta

Jordan

Mitov

et al. 2016

International Journal of Pharmaceutics

View full text Add to dashboard Cite

Mitochondria are considered to be the “power plants” of the cell, but can also initiate and execute cell death, stimulated by oxidative stress (OS). OS induced mitochondrial dysfunction is characterized by a loss in oxygen consumption and reduced ATP production. Curcumin, as a potential therapeutic, has been explored as a candidate for mitochondrial OS suppression, but rapid metabolism and aqueous insolubility has prevented it from being effective. Further, efficient delivery of curcumin via the incorporation into nanocarriers has again been limited due to low drug loading capacities and/or significant burst release, resulting in acute cytotoxicity. Hence, to increase the therapeutic potential and reduce the toxic effects of curcumin, curcumin conjugated poly(β-amino ester) nanogels (CNGs) were synthesized using Michael addition chemistry. This approach provided easy control over the nanogel size, with CNGs showing a uniform release of active curcumin over 48 hours with no burst release. This controlled release system significantly increased the safety limit for curcumin, with a ten fold increase in the cytotoxic threshold, as compared to free curcumin. Further, real-time mitochondrial response analysis with the Seahorse XF96 showed effective and prolonged suppression of H2O2 induced mitochondrial oxidative stress upon pre-treating endothelial cells with CNGs and this potential of nanogels was studied at different pre-treatment times prior to H2O2 exposure.

show abstract

Curcumin decreases oxidative stress in mitochondria isolated from liver and kidneys of high-fat diet-induced obese mice

Cited by 48 publications

References 22 publications

Neuroprotective activities of curcumin and quercetin with potential relevance to mitochondrial dysfunction induced by oxaliplatin

Neuroprotective activities of curcumin and quercetin with potential relevance to mitochondrial dysfunction induced by oxaliplatin

Effect of curcumin on hepatic heme oxygenase 1 expression in high fat diet fed rats: is there a triangular relationship?

Controlled curcumin release via conjugation into PBAE nanogels enhances mitochondrial protection against oxidative stress

Contact Info

Product

Resources

About