Curcumin Decreases Survival of Hep3B Liver and MCF-7 Breast Cancer Cells

Ströfer, Mareike; Jelkmann, Wolfgang; Depping, Reinhard

doi:10.1007/s00066-011-2248-0

Cited by 75 publications

(42 citation statements)

References 49 publications

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“…Curcumin potently inhibited HIF1A protein production both in rodent endocrine pituitary tumour cell lines and in cells of different human pituitary adenoma types. This has also been observed for curcumin and its derivatives in a variety of cell lines serving as models of different types of tumours (Bae et al 2006, Thomas et al 2008, Jung et al 2010, Ströfer et al 2011.…”

Section: Discussionsupporting

confidence: 52%

“…In a series of carcinoma cell lines, it has been shown that curcumin was not able to affect HIF1A production but suppressed HIF1 by down-regulating HIF1B (aryl hydrocarbon receptor nuclear translocator (ARNT)), the hypoxia-independent subunit of HIF1 (Choi et al 2006). In other cell types, curcumin concomitantly suppressed HIF1A and HIF1B (Ströfer et al 2011).…”

Section: Discussionmentioning

confidence: 99%

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Curcumin suppresses HIF1A synthesis and VEGFA release in pituitary adenomas

Shan

Schaaf

Schmidt³

et al. 2012

Journal of Endocrinology

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Curcumin (diferuloylmethane), a polyphenolic compound derived from the spice plantCurcuma longa, displays multiple actions on solid tumours including anti-angiogenic effects. Here we have studied in rodent and human pituitary tumour cells the influence of curcumin on the production of hypoxia inducible factor 1α (HIF1A) and vascular endothelial growth factor A (VEGFA), two key components involved in tumour neovascularisation through angiogenesis. Curcumin dose-dependently inhibited basal VEGFA secretion in corticotroph AtT20 mouse and lactosomatotroph GH3 rat pituitary tumour cells as well as in all human pituitary adenoma cell cultures (n=32) studied. Under hypoxia-mimicking conditions (CoCl2treatment) in AtT20 and GH3 cells as well as in all human pituitary adenoma cell cultures (n=8) studied, curcumin strongly suppressed the induction of mRNA synthesis and protein production of HIF1A, the regulated subunit of the hypoxia-induced transcription factor HIF1. Curcumin also blocked hypoxia-induced mRNA synthesis and secretion of VEGFA in GH3 cells and in all human pituitary adenoma cell cultures investigated (n=18). Thus, curcumin may inhibit pituitary adenoma progression not only through previously demonstrated anti-proliferative and pro-apoptotic actions but also by its suppressive effects on pituitary tumour neovascularisation.

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Section: Discussionsupporting

confidence: 52%

Section: Discussionmentioning

confidence: 99%

Curcumin suppresses HIF1A synthesis and VEGFA release in pituitary adenomas

Shan

Schaaf

Schmidt³

et al. 2012

Journal of Endocrinology

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“…Interestingly, curcumin facilitated the degradation of ARNT and blocked HIF signalling [14]. Similar effects were reported by Ströfer et al [15]. Curcumin-mediated ARNT depletion was observed in human HepG2, Hep3B and MCF-7 cells [15].…”

Section: Upregulation Of Arnt In Response To Hypoxiasupporting

confidence: 76%

Hypoxic Upregulation of ARNT (HIF-1β): A Cell-Specific Attribute with Clinical Implications

Mandl¹,

Depping²

2017

Hypoxia and Human Diseases

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According to the current point of view described in the literature, the transcription factor aryl hydrocarbon receptor nuclear translocator (ARNT), also designated as hypoxiainducible factor (HIF)-1β, is constitutively expressed and not influenced by oxygen tension. However, a study published two decades ago provided early evidence regarding a hypoxia-dependent ARNT upregulation. This finding was subsequently challenged and neglected. Until now, only a limited number of publications focus on the regulation of ARNT in hypoxia. Therefore, appropriate studies and the putative mechanism mediating this cellular attribute are discussed. The advantages of an elevated ARNT expression level in tumour cells are delineated. This chapter provides an overview of hypoxia-inducible ARNT as an emerging concept in HIF biology.

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“…Це жовтий пігмент, отриманий з коренів рослини Curcuma longa, який використову-ється як біологічно активна добавка в терапії атеросклерозу, цукрового діабету, при алер-гічних захворюваннях. Він має протектив-ний ефект при пошкодженнях міокарда [8], впливає на активність цитокінів, ензимів та транскрипційних факторів, пов'язаних із гіпоксією [9], а також зменшує токсичний вплив доксорубіцину на серце, печінку та нирки за рахунок його антиоксидантних властивостей [10][11][12]. Водночас комплексне вивчення протективного ефекту куркуміну на мітохондріальний апарат кардіоміоцитів при застосуванні антрациклінів досі не про-водилося.…”

Section: вступunclassified